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  • Articles  (29)
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  • Process Engineering, Biotechnology, Nutrition Technology  (29)
  • 1
    Electronic Resource
    Electronic Resource
    Release of hydrogen sulfide and methyl mercaptan from sulfur-containing amino acids (1971)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 19 (1971), S. 775-779 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60176a026
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  • 2
    Electronic Resource
    Electronic Resource
    Mineralization of .alpha.-, .gamma.-, and .beta.-Isomers of Hexachlorocyclohexane by a Soil Bacterium under Aerobic Conditions (1995)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 43 (1995), S. 833-837 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00051a052
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  • 3
    Electronic Resource
    Electronic Resource
    Genome shuffling of Lactobacillus for improved acid tolerance (2002)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 20 (2002), S. 707-712 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fermentation-based bioprocesses rely extensively on strain improvement for commercialization. Whole-cell biocatalysts are commonly limited by low tolerance of extreme process conditions such as temperature, pH, and solute concentration. Rational approaches to improving such complex ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0702-707
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  • 4
    Electronic Resource
    Electronic Resource
    Incomplete mixing in large bioreactors — a study of its role in the fermentative production of streptokinase (1996)
    Springer
    Bioprocess and biosystems engineering 14 (1996), S. 91-96 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The production of streptokinase in a batch fermentation has been analysed for the role of incomplete macromixing of the broth. The analysis is based on a kinetic model exhibiting inhibition by the substrate and a primary metabolite (lactic acid), and a mixing model comprising two continuous flow reactors (CFRs) with closed-loop recycle. The inoculum is introduced into one region (one CFR) and the mixing process determines its distribution, growth and reactivity. By varying the dilution rates of the CFRs, any degree of macromixing can be simulated. For dilution rates larger than 1.0 h−1 almost complete macromixing is achieved, for which an analogy has been drawn with micromixing. Increasing the volume of the inoculated region relative to the noninoculated region improves the maximum attainable activity of streptokinase and shortens the time for this. In such a situation an imperfectly mixed bioreactor is superior to a perfectly mixed one, implying that good productivity requires a large inoculated region and incomplete macromixing. These inferences are supported by earlier studies of fluid mixing and relaxation times in bioreactors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387962
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  • 5
    Electronic Resource
    Electronic Resource
    Start-up sensitivity to the initial state of a batch bioreactor for a recombinant Escherichia coli in a complex medium (1996)
    Springer
    Bioprocess and biosystems engineering 15 (1996), S. 215-219 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The sensitivities with respect to the initial state of five key variables describing the performance of a batch bioreactor have been computed from an experimentally validated kinetic model. The system has a recombinant Escherichia coli strain containing the plasmid pBR Eco gap, which codes for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in a complex medium. Since previous studies have shown the start-up sensitivities to be particularly important, the initial 10% of the duration of fermentation was chosen as the time span. The sensitivities of the cell mass, GAPDH and acetate increased with time while those of glucose and yeast extract remained practically constant. Acetate has a crucial role as it functions as both a product and a reactant. With no acetate in the inoculum, the sensitivities of acetate increased an order of magnitude faster than other sensitivities. However, upon addition of acetate through the inoculum, its sensitivities decreased the fastest and stabilised beyond a starting concentration of about 1 g/l whereas other sensitivities stabilised after 5 to 6 g/l of initial acetate. A three-dimensional envelope in the space of acetate concentration-time-relative sensitivity shows a locus of concentrations for minimum time-dependent acetate sensitivity; this may be maintained through fed-batch operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369485
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of bifurcations in continuous fermentation using recombinant microorganisms with delayed responses (1995)
    Springer
    Bioprocess and biosystems engineering 12 (1995), S. 199-203 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract When the feed rate to a fermenter is varied periodically in order to favor the growth of plasmid-containing cells, a transition may occur from the starting stationary state to another state. The resulting state may be constant or oscillatory. A generalised model based on the adaption times of plasmid-free and plasmid-harboring cells has been used. Analytical conditions have been derived for bifurcation from one nonoscillatory state to another or to an oscillatory state (Hopf bifurcation). The frequency of oscillation is shown to have an upper bound, which can be controlled by manipulating certain process parameters. The production of tryptophan synthetase by the plasmid pPLc23trpAl in E. coli is used as an example to determine the nature of the Hopf bifurcations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01767467
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  • 7
    Electronic Resource
    Electronic Resource
    A heuristic approach to fed-batch optimisation of streptokinase fermentation (1995)
    Springer
    Bioprocess and biosystems engineering 13 (1995), S. 109-112 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Previous studies have shown that the rate of formation of streptokinase, a secondary metabolite, in batch fermentation is proportional to the specific growth rate of the biomass, which in turn is inhibited by its substrate and the primary product (lactic acid). These kinetics suggest the suitability of fed-batch operation to increase the yield of streptokinase. A near-optimal feed policy has been calculated by the chemotaxis algorithm, and it shows a substrate feed rate decreasing nonlinearly and vanishing after 11 hours. This is followed by batch fermentation for a further 8 hours, at the end of which 12% more streptokinase is generated than by purely batch fermentation. Further improvements in productivity are possible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00420437
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  • 8
    Electronic Resource
    Electronic Resource
    Analysis of bifurcations in continuous fermentation using recombinant microorganisms with delayed responses (1995)
    Springer
    Bioprocess engineering 12 (1995), S. 199-203 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  When the feed rate to a fermenter is varied periodically in order to favor the growth of plasmid-containing cells, a transition may occur from the starting stationary state to another state. The resulting state may be constant or oscillatory. A generalised model based on the adaption times of plasmid-free and plasmid-harboring cells has been used. Analytical conditions have been derived for bifurcation from one nonoscillatory state to another or to an oscillatory state (Hopf bifurcation). The frequency of oscillation is shown to have an upper bound, which can be controlled by manipulating certain process parameters. The production of tryptophan synthetase by the plasmid pPLc23trpA1 in E. coli is used as an example to determine the nature of the Hopf bifurcations. List of symbols D l/h dilution rate K m g/l Monod constant p– probability of plasmid loss per generation s g/l substrate concentration t h time T i h delay time of cells of i-th kind x i g/l concentration of cells of i-th kind Y i g/g yield coefficient of cells of i-th kind Greek symbols μ i l/h specific growth rate of i-th species μ im l/h maximum possible value of μ i τ h generalised delay time Subscripts 1 cells without plasmids 2 cells with plasmids s steady state Superscript o inlet stream
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01767467
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  • 9
    Electronic Resource
    Electronic Resource
    Transient sensitivity analysis of a cybernetic model of microbial growth on two substrates (1999)
    Springer
    Bioprocess engineering 21 (1999), S. 135-140 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract When a microbe has a choice of two substrates for its growth in a fermentation medium, its preference varies with the substrates and with time. This “informed” choice is conveniently expressed by cybernetic models. For the growth of Klebsiella oxytoca in a medium of glucose and lactose, a one-parameter cybernetic model of growth has been employed in a batch bioreactor to analyse sensitivity of the fermentation to perturbations in the parameter, α (0 ≤ α ≤ 1). The sensitivity surfaces in the (α-time) space show interesting variations which are discussed. An important observation is that while growth is best promoted with α=1, i.e. sequential consumption of the substrates [8], low sensitivities require smaller values of α, i.e. simultaneous utilisation. Thus, in a realistic operation it may be necessary to compromise between high growth (with subsequent high productivity) and low sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004490050653
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  • 10
    Electronic Resource
    Electronic Resource
    Spectral analysis of a nonideal bioreactor for a recombinant fermentation with run-away plasmids (1999)
    Springer
    Bioprocess engineering 20 (1999), S. 31-36 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract An earlier application of spectral analysis to an isothermal, perfectly mixed, fed-batch fermentation [11] showed that it provides insight into the performance and reveals significant differences between key extra-cellular and intra-cellular (recombinant) variables. To enable application on a practically useful scale, the methodology has been extended to a bioreactor with temperature variation, incomplete mixing of the broth and Gaussian disturbances. For the same system, β-galactosidase produced by a recombinant E. coli strain, there are again differences between the rDNA and its protein, on the one hand, and the concentration and mass fraction of recombinant cells, on the other. For certain combinations of the dilution rate and the degrees of mixing, the bioreactor is only marginally stable, implying that a sufficiently large disturbance can trigger unstable behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004490050556
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