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  • 1
    Electronic Resource
    Electronic Resource
    Glucose and insulin changes following a renoportal shunt in streptozotocin diabetic rats with pancreatic islet isografts under the kidney capsule (1982)
    Springer
    Diabetologia 23 (1982), S. 343-346 
    Details
    ISSN: 1432-0428
    Keywords: Insulin ; glucose ; glucose tolerance ; rat ; portal blood flow ; pancreatic transplantation ; pancreatic islets ; streptozotocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect on glucose metabolism of altering the site of the venous drainage of an isograft of isolated adult islets implanted beneath the renal capsule, from the systemic circulation to the portal circulation was determined in streptozotocin-induced diabetic rats. Reversal of diabetes was accomplished by the transplantation of 1000–1200 isolated islets beneath the left kidney capsule. The rate of fall of the glucose concentration (as expressed by the K value) was found to be significantly decreased in transplanted animals (1.7 ± 0.5%/min; mean ± SD) compared with normal animals (2.4 ± 0.5%/min). Draining the left renal vein into the portal circulation restored the K value to that of normal animals (2.5 ± 0.4%). However the fasting glucose concentration was significantly higher and the basal insulin levels lower in both normal and transplanted rats with a renoportal shunt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253742
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of hyperglycaemia on pancreatic islets transplanted into rats beneath the kidney capsule (1989)
    Springer
    Diabetologia 32 (1989), S. 663-667 
    Details
    ISSN: 1432-0428
    Keywords: Hyperglycaemia ; islet transplantation ; diabetes ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of hyperglycaemia on islet transplantation in the rat has been examined in two ways, using syngeneic transplantation of 400 islets to the kidney capsule and subsequent measurement of kidney insulin content as a measurement of B-cell survival. Firstly, islets were transplanted into either diabetic or normal rats, then 6 months later the composite kidney/islet graft was transplanted into a normal rat. The insulin content was measured after a further 6 months and was found to be significantly reduced in islets exposed to hyperglycaemia in the primary recipient. These findings are interpreted as showing that long-term exposure of islets to hyperglycaemia results in B-cell loss. In the second experiment 400 islets were transplanted into either a long-term (6 months) diabetic or a normal rat. Two weeks later the composite kidney/islet graft was transplanted into a normal rat. The insulin content was measured after a further 6 months and no significant difference was found, whether the primary recipient was diabetic or not. These results are interpreted as showing that islet graft implantation is not impaired in long-term diabetic rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274254
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  • 3
    Electronic Resource
    Electronic Resource
    311. Eine neue und einfache Methode der auxilliären Lebertransplantation in der Ratte (1982)
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 582-582 
    Details
    ISSN: 1435-2451
    Keywords: Liver transplantation ; Rat ; Technique ; Lebertransplantation ; Ratte ; Technik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine einfache Technik wurde für vascularisierte Lebertransplantate entwickelt: Der Pfortaderkreislauf wurde unter Verwendung der renalen Gefäße hergestellt und die Galle in den Ureter drainiert; Nierenarterie zu Pfortader unter Verwendung eines Stent, Nierenvene End-zu-End zu inferior Vena Cava mittels fortlaufender Naht, 10-0 Nylon. Ureter zu Gallengang unter Verwendung eines Stent. Das neue Modell ermöglicht geringe Letalität, kurze Operations- und Ischämiezeiten und war in mehr als 100 Transplantationen für immunologische Untersuchungen erfolgreich.
    Notes: Summary A simple technique was developed for vascularized liver grafts in order to provide consistent reproducibility. Portal circulation was established using the host's renal vessels and ureter for bile drainage: renal vein to inferior vena cava end to end, using continuous 10-0 nylon; renal artery to portal vein using a stent and bile duct to ureter using a stent. The new model provides low mortality, short operation time and ischemia time and was successful in more than 100 transplants for immunological studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01272057
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  • 4
    Electronic Resource
    Electronic Resource
    368. Standardisierte mikrochirurgische Gefäßtechnik —End/End und End/Seit-Anastomosen in der experimentellen Transplantationschirurgie (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 912-912 
    Details
    ISSN: 1435-2451
    Keywords: Transplantation ; Techniques ; Microsurgery ; Transplantation ; Technik ; Mikrochirurgie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Herz-, Nieren-, Milz-, Pankreas- und Lebertransplantate wurden mit 4 verschiedenen Gefäßanastomosen ausgeführt. End-zu-End-Einzelkopfnaht — fortlaufende Naht. End-zu-Seit-Einzelkopfnaht —fortlaufende Naht. End-zu-End-Anastomosen erschienen insgesamt sicherer, End-zu-Seit technisch einfacher. Fortlaufende Nähte haben sich besonders an venösen Anastomosen bewährt. Die beschriebenen Techniken werden für die experimentelle und klinische Anwendung empfohlen.
    Notes: Summary Heart, kidney, spleen, pancreas and liver grafts have been performed using four different techniques for vascular anastomoses: “end-to-end” interrupted sutures and continuous sutures. “End-to-side” interrupted sutures and continuous sutures. End-to-end seems to be the safer technique, end-to-side to be technically easier. Continuous sutures are the choice for venous anastomoses. These techniques can be recommended for experimental as well as clinical use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276194
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  • 5
    Electronic Resource
    Electronic Resource
    312. Organtransplantation in der Ratte — Nieren, Herz, Leber und Pankreastransplantationen unter Verwendung der Nierengefäße (1982)
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 582-583 
    Details
    ISSN: 1435-2451
    Keywords: Rat ; Organ transplantation ; Technique ; Ratte ; Organtransplantation ; Technik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Über 3000 Transplantationen wurden unter Verwendung der renalen Gefäße für Herz, Nieren, Leber und Pankreastransplantationen durchgeführt: Empfänger Herz Niere Leber Pankreas a. coeliaca carotis comm. a. renalis a. coeliaca a. coeliaca v. renalisa. pulmonalis v. renalis vena cava vena portae ureter - ureter duct chol. duct chol. Die Verwendung der renalen Gefäße erwies sich als geeignete Methode mit niedriger Empfängermortalität, sie ermöglicht „End zu End”-Anastomosen, die sicherer sind als „End-zu-Seit”.
    Notes: Summary More than 3000 transplants were performed using the renal vessel for heart, kidney, liver, and pancreas: Recipient Heart Kidney Liver Pancreas Renal artery Common carotis Renal artery Coeliac artery Coeliac artery Renal vein Pulmonal artery Renal vein I.V.C. Portal vein Ureter - Ureter Bile duct Bile duct The use of the renal vessels provides a convenient and accessible site with low recipient mortality for simple end-to-end anastomoses, which are safer then end to side.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01272058
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