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  • Suprachiasmatic nucleus  (1)
  • collagen expression  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Effect of angiotensin coverting enzyme inhibitor on regression in cardiac hypertrophy (1993)
    Springer
    Molecular and cellular biochemistry 119 (1993), S. 23-28 
    Details
    ISSN: 1573-4919
    Schlagwort(e): cardiac hypertrophy ; cardiac regression ; enalapril ; collagen expression ; adrenergic receptor ; rat heart
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Cardiac hypertrophy in rats was produced by aortic banding for 6 weeks and regression of hypertrophy in these experimental animals was induced by administration of angiotensin converting enzyme inhibitor, enalapril (10 mg/kg/ day) for 6 weeks. The left ventricular muscle mass and systolic pressure were decrease upon treating the hypertrophied rats with enalapril. This drug also decreased the number of α1-adrenoceptors in hypertrophyied myocardium without any changes in β-adrenoceptors. The regression of cardiac hypertrophy in spontaneously hypertensive rats by enalapril for 10 weeks was not associated with any alterations in α1-adrenoceptors in hypertrophied myocardium, but was decreased in β-adrenoceptors. Effects of enalapril on extracellular matrix in the myocardium was also observed in regression of hypertrophy in which the type III collagen mRNA expression and collagen contents were reduced in comparison with those of hypertrophied myocardium. These results indicate that regression of cardiac hypertrophy is not alway associated with a decrease in the number of α1-adrenergic receptors and that the beneficial effects of enalapril in the hypertrophied heart in aortic banding animals may be of some specific nature.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00926849
    Standort Signatur Einschränkungen Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 2
    Digitale Medien
    Digitale Medien
    Role of the suprachiasmatic nuclei of the hypothalamus on diurnal rhythm in cardiac arrhythmias (1986)
    Springer
    Heart and vessels 2 (1986), S. 15-22 
    Details
    ISSN: 1615-2573
    Schlagwort(e): Cardiac bradyarrhythmias ; Diurnal rhythm ; Suprachiasmatic nucleus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ambulatory EGG and EEG recordings were recorded under a 14/10-h light-dark illumination schedule using rats. The rats consisted of two groups: a suprachiasmatic (Sch) lesioned group (n=5) and a normal control group (n=5). Bilateral Sch nuclei were lesioned electrically (DC, 2.5 mA, 30 s for each) using a pair of platinum electrodes 0.3 mm in diameter. After recovery from surgery, recordings of ECGs (leads I, II, and III) and EEGs from the cortex and the left dorsal hippocampus were continued for 6 days. Diurnal periodicity in bradyarrhythmia (sinoatrial block, atrioventricular block) and heart rate was analyzed by the least square fit of 24-h cosines. Significant diurnal rhythm was observed in control rats, whereas Sch-lesioned rats showed no significant diurnal rhythm. The integrity of the Sch nuclei, therefore, is necessary for the generation and/or the expression of diurnal periodicity in bradyarrhythmia in rats.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02060239
    Standort Signatur Einschränkungen Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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