ISSN:
1434-4475
Keywords:
α-Aspartyl peptides
;
N-Maleylamino acid derivatives
;
Nucleophilic addition
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary During the addition of amines to maleylamino acids in general β-amino derivatives are formed. In order to change the reactivity within the vinylogous maleyl system we introduced the β-benzylester group into the starting compound N-(cis-β-carboxyacryloyl)-phenylalanine methylester1. The obtained benzylester2 is adding benzylamine in α-position yielding N-benzyl-α-aspartyl(β-benzyl)-phenylalanine methylester4. The addition reaction was investigated by1H-NMR-spectroscopy. The structures of the compounds have been confirmed by elemental analysis, IR,1H-NMR and13C-NMR spectroscopy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00816859
Permalink