Summary
During the addition of amines to maleylamino acids in general β-amino derivatives are formed. In order to change the reactivity within the vinylogous maleyl system we introduced the β-benzylester group into the starting compound N-(cis-β-carboxyacryloyl)-phenylalanine methylester1. The obtained benzylester2 is adding benzylamine in α-position yielding N-benzyl-α-aspartyl(β-benzyl)-phenylalanine methylester4. The addition reaction was investigated by1H-NMR-spectroscopy. The structures of the compounds have been confirmed by elemental analysis, IR,1H-NMR and13C-NMR spectroscopy.
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Griehl, C., Ströhl, D., Jeschkeit, H. et al. Synthetische und NMR-spektroskopische Untersuchungen der Benzylaminaddition an N-Maleyl-aminosäurederivate. Monatsh Chem 123, 647–654 (1992). https://doi.org/10.1007/BF00816859
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DOI: https://doi.org/10.1007/BF00816859