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  • 1
    Electronic Resource
    Electronic Resource
    Long-term response to human growth hormone in 36 children with idiopathic growth hormone deficiency (1979)
    Springer
    European journal of pediatrics 132 (1979), S. 221-238 
    Details
    ISSN: 1432-1076
    Keywords: Idiopathic growth hormone deficiency ; Diagnosis ; Aetiology ; Treatment ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The results of long term treatment with human growth hormone (Crescormon®, 12.4 IU/m2/week) in 36 patients with idiopathic growth hormone deficiency are given. Birth trauma—in particular assisted breech delivery (30%)—is the major aetiological cause. Twelve patients had isolated growth hormone deficiency (IGHD), 24 had multiple pituitary hormone deficiencies (MPHD) of which 19 were treated with additional thyroid hormones. The results were judged by the criteria of height velocity, total height gain and change of height prediction (TW2, age based). It is concluded that the growth hormone dose chosen in many cases is insufficient to maintain high growth rates after the first year of treatment, when “catch-up” no longer takes place. The tendency of patients supplemented with thyroid hormone to grow better—without additional bone-age advancement—calls for careful search for hypothyroidism and suggests the use of thyroxin in cases of doubt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496846
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Multiple metachronous skin squamous cell carcinomas and epidermodysplasia verruciformis in the head region: a human papilloma virus-associated disease (1994)
    Springer
    European archives of oto-rhino-laryngology and head & neck 251 (1994), S. 342-346 
    Details
    ISSN: 1434-4726
    Keywords: epidermodysplasia verruciformis ; Human papilloma virus ; Head and neck ; Diagnosis ; Treatment In situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Data from a young adult man with epidermodysplasia verruciformis (EV) and multiple metachronous spinaliomas in the head and neck region are presented. Diagnosis of this rare, human papilloma virus (HPV)-associated disease was based on: (1) Typical skin lesions, including viral warts, verruca plana-type lesions and pityriasis versicilor; (2) typical histological features, including ‘foamy giant keratinocytes”; (3) evidence of HPV 5, 8 and 20 in pityriasis versicilor-like lesions; (4) a cellular immunodeficiency due to a relative T-helper-cell deficit. No specific treatment of EV is known, so that therapy concentrates on early removal of spinaliomas and treatment of intercurrent infections. Since EV patients have numerous benign skin lesions and frequently develop metastatic and non-metastatic carcinomas, molecular changes of HPV during carcinogenesis can be studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171541
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    Paper (German National Licenses)
    Fulltext
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