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  • Helicobacter pylori  (6)
  • peptic ulcer  (2)
  • CagA  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Helicobacter pylori and Zollinger-Ellison syndrome (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 15-18 
    Details
    ISSN: 1573-2568
    Schlagwort(e): Campylobacter pylori ; Helicobacter pylori ; Zollinger-Ellison syndrome ; peptic ulcer ; gastric acid secretion ; gastrin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Helicobacter pylori (previouslyCampylobacter pylori) is almost invariably associated with chronic duodenal ulcer disease. The relationship betweenH. pylori infection and duodenal ulcer in Zollinger-Ellison syndrome is unknown. We investigated the frequency ofH. pylori infection in Zollinger-Ellison syndrome and also what effectH. pylori infection had on gastric function in patients with Zollinger-Ellison syndrome.H. pylori infection was diagnosed based on a specific serologic (ELISA) assay based on high-molecular-weight cell-associated proteins ofH. pylori. We studied 20 patients with Zollinger-Ellison syndrome; 15 men and 5 women ranging in age from 24 to 71 years, median age 51. Six Zollinger-Ellison syndrome patients hadH. pylori infection compared to 100 consecutive patients with chronic recurrent duodenal ulcer disease (P〈0.05). Pretreatment basal acid output in Zollinger-Ellison syndrome patients ranged from 7.9 to 95.0 mmol/hr, median 35.2. Pentagastrin-stimulated maximal acid output ranged from 8.5 to 132 mmol/hr, median 52.7. Acid secretion was lower in theH. pylori-infected patients than the uninfected patients (BAO 24.5±6.5 vs 45.4±6.6, and MAO 44.3±11.8 vs 67.9±10.7, forH. pylori infected vs uninfected patients, respectively). The difference in BAO was statistically significant (P〈0.05). The present results indicate thatH. pylori is not a major contributing factor in duodenal ulcer associated with Zollinger-Ellison syndrome. The association of a reduced BAO withH. pylori suggests that these findings may be related.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01300080
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  • 2
    Digitale Medien
    Digitale Medien
    We need to integrate new data concerningHelicobacter pylor into experimental ulcer research (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 2487-2489 
    Details
    ISSN: 1573-2568
    Schlagwort(e): Helicobacter pylori ; ulcer research ; data
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02063261
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  • 3
    Digitale Medien
    Digitale Medien
    Search for Putative Virulence Factors of Helicobacter pylori (The Low-Molecular-Weight (33-35 K) Antigen) (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 1482-1487 
    Details
    ISSN: 1573-2568
    Schlagwort(e): HELICOBACTER PYLORI ; LOW-MOLECULAR-WEIGHT ANTIGEN ; 33-35 K ANTIGEN ; CagA ; VacA ; PATHOGENESIS
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Early studies suggested that two Helicobacterpylori proteins, CagA and VacA, were virulence factors.Support for that hypothesis has been undermined bygeographic differences in prevalence of these antigens. To identify other possible putative virulencefactors by establishing a relationship between antigensand different H. pylori diseases, two commercialavailable immunoblot assay kits, HelicoBlot 2.0(Genelabs Diagnostics, Singapore) and RIDA BlotHelicobacter (R-Biopharm GmbH, Darmstadt, Germany), wereused to investigate the prevalence of various specificantigen seropositivity in 80 H. pylori-infected Japanese (20 each with gastritis, duodenal ulcer,gastric ulcer, or gastric cancer). The production ofinterleukin-8 (IL-8) in biopsy specimens was alsomeasured by enzyme-linked immunosorbent assay (ELISA).Both assays had 100% sensitivity; specificity was90% for HB2.0 and 80% for RIDA-BH. With the exception ofthe 33-35 K antigen, there was no relationship betweenantigens, endoscopic diagnoses, histological findings, or mucosal IL-8 levels. The 33-35 Kantigen was present in 97.5% (39 of 40) patients withgastric or duodenal ulcer compared to 70% (14 of 20)those with chronic gastritis (P 〈 0.006). The mean IL-8 levels in the corpus wassignificantly higher in those with antibody to the 33-35K antigen compared to those without (105.4 ± 22pg/mg vs 10.2 ± 8.8 pg/mg) (P = 0.015). There wasno relationship between other antigens including CagA andproduction of IL-8. In conclusion, thelowmolecular-weight 33-35 K antigen may play animportant role in the pathogenesis of H. pylori-relateddisease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1018850412148
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  • 4
    Digitale Medien
    Digitale Medien
    Determination ofHelicobacter pylori status by reverse transcription-polymerase chain reaction (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 109-113 
    Details
    ISSN: 1573-2568
    Schlagwort(e): Helicobacter pylori ; RT-PCR ; urea breath test ; polymerase chain reaction ; detection ; transmission ; epidemiology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We previously reported the development and the possible application of reverse transcription-polymerase chain reaction (RT-PCR) assay for the detection ofH. pylori in gastric mucosal biopsy specimens. In this communication, the application of this assay was assessed by comparing its results from 79 gastric biopsy specimens obtained from 68 patients with the more traditional [13C]urea breath test. When the amplified products were examined, the specificity and sensitivity of this RT-PCR assay were 100% and 47% on agarose gels and 80% and 91% by Southern hybridization, respectively. The specificity and sensitivity of urea breath test were 91% and 96% and were generally superior to RT-PCR (negative predictive value of 94% for UBT and 59–76% for RT-PCR). Although our RT-PCR results compare favorably with other PCR assays applied to gastric biopsy specimens for the detection ofH. pylori, the use of this method did not add significantly to currently available noninvasive diagnostic methods.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02063952
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  • 5
    Digitale Medien
    Digitale Medien
    Effect of Pretreatment Antibiotic Resistance to Metronidazole and Clarithromycin on Outcome of Helicobacter pylori Therapy (2000)
    Springer
    Digestive diseases and sciences 45 (2000), S. 68-76 
    Details
    ISSN: 1573-2568
    Schlagwort(e): meta-analysis ; metronidazole ; clarithromycin ; resistance ; Helicobacter pylori ; therapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Our purpose was to define the effect of pretreatment Helicobacter pylori resistance to metronidazole or to clarithromycin on the success of antimicrobial therapy. We used 75 key words to perform a literature search in MEDLINE as well as manual searches to identify clinical treatment trials that provided results in relation to H. pylori susceptibility to metronidazole and clarithromycin or both during the period 1984–1997 (abstracts were not included). Meta-analysis was done with both fixed- and random-effect models; results were shown using Galbraith's radial plots. We identified 49 papers with 65 arms for metronidazole (3594 patients, 2434 harboring H. pylori strains sensitive to metronidazole and 1160 harboring resistant strains). Metronidazole resistance reduced effectiveness by an average of 37.7% (95% CI = 29.6–45.7%). The variability in the risk difference for metronidazole was 122.0 to −90.6 and the chi-square value for heterogeneity was significant (P 〈 0.001). Susceptibility tests for clarithromycin were performed in 12 studies (501 patients, 468 harboring H. pylori strains sensitive to clarithromycin and 33 harboring resistant strains). Clarithromycin resistance reduced effectiveness by an average of 55% (95% CI = 33–78%). We found no common factors that allowed patients to be divided into subgroups with additional factors significantly associated with resistance. In conclusion, metronidazole or clarithromycin pretreatment resistant H. pylori are the main factors responsible for treatment failure with regimens using these compounds. If H. pylori antibiotic resistance continues to increase, pretherapy antibiotic sensitivity testing might become necessary in many regions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1005457226341
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  • 6
    Digitale Medien
    Digitale Medien
    DNA-DNA hybridization demonstrates apparent genetic differences betweenHelicobacter pylori from patients with duodenal ulcer and asymptomatic gastritis (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 1128-1131 
    Details
    ISSN: 1573-2568
    Schlagwort(e): Helicobacter pylori ; DNA ; hybridization ; duodenal ulcer ; gastric ulcer ; gastritis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We asked whether different clinical outcomes ofHelicobacter pylori infection might be a reflection of genetic differences in infecting organisms. Using DNA-DNA hybridization we examined whether hybridization levels groupedH. pylori isolates corresponding to the type of disease (gastric ulcer, duodenal ulcer, asymptomatic gastritis) from which they were recovered. Target DNAs were prepared fromH. pylori strains cultured from gastric biopsy specimens of 25 patients; 5 with gastric ulcers, 9 with duodenal ulcers, and 11 from asymptomatic volunteers endoscopically proven not to have peptic ulcer disease. DNA-DNA hybridization was performed with whole genomic probes made from an isolate from each of the three disease categories. Using a DNA probe from an isolate from a duodenal ulcer patient, we found that isolates from patients with duodenal ulcer and nonulcer gastritis yielded significant differences in levels of hybridization. The levels of hybridization of DNA fromH. pylori isolates from duodenal ulcer patients, gastric ulcer patients and nonulcer gastritis controls were 85.5%±7%, 83%±3%, and 78.3%±5%, respectively (mean±sd), and the difference between the hybridization levels obtained with duodenal ulcer and nonulcer control target DNAs was statistically significant (P=0.025). These data suggest that the outcome of infection (eg, ulcer or no ulcer) may be due to virulence factors encoded by genomic DNA. If such differences exist, it should be possible to produce probes that would identify the ulcer virulence gene(s) and clearly distinguish between ulcerogenic and nonulcerogenic strains ofH. pylori.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01295731
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  • 7
    Digitale Medien
    Digitale Medien
    Omeprazole versus placebo in duodenal ulcer healing (1990)
    Springer
    Digestive diseases and sciences 35 (1990), S. 66-72 
    Details
    ISSN: 1573-2568
    Schlagwort(e): Duodenal ulcer ; peptic ulcer ; controlled trial ; omeprazole ; ulcer therapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The study objective was to study the ulcer healing effects and safety of the proton pump inhibitor, omeprazole, given in a dose of 20 mg once daily before breakfast. The study design was a randomized, double-blind, multicenter comparison of omeprazole and placebo using endoscopy to assess ulcer healing after two or four weeks of therapy. One hundred fifty-three patients with endoscopically documented active duodenal ulcer were studied. One hundred two patients received omeprazole and 51 received placebo. Patients in both groups were similar with regard to age, sex, duration of disease, initial ulcer size, smoking history, and alcohol use. A “per protocol” analysis of healing rates showed a significant advantage for omeprazole (P〈0.01) at both week 2 (41% vs 13%) and week 4 (75% vs 27%). Concomitant factors (including smoking and ulcer size) did not alter the significance of the differences in healing rates between omeprazole and placebo. Complete relief of day and night pain was more often achieved (P〈0.01) in the omeprazole group. “All-patients treated” analyses for healing and pain relief gave results similar to the respective “per protocol” analyses. Omeprazole was well tolerated; fewer patients had clinical and laboratory adverse experiences in the omeprazole group than in the placebo group. Fasting serum gastrin levels increased with omeprazole therapy (mean 34.9 to 73.5 pg/ml) but exceeded the normal range (〉150 pg/ml) in only 12.3% of patients. Two weeks after therapy was stopped, serum gastrin levels showed a decrease toward baseline but had not yet completely returned to pretreatment levels (mean 49.7 pg/ml). Observations from Europe and Australia of 〉90% healing of duodenal ulcers after four weeks of omeprazole therapy were not confirmed in this study. No single factor explains this difference. Considerable variation in the degree of suppression of acid secretion has been demonstrated with the 20-mg daily dose of omeprazole; it is possible that, in US populations, a greater degree of antisecretory effect may be required to achieve the healing rates observed in Europe and Australia. In conclusion, omeprazole was more effective than placebo in the treatment of active duodenal ulcer, as determined by ulcer healing and relief of pain, and was well tolerated in the short-term treatment of patients with duodenal ulcer.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01537225
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  • 8
    Digitale Medien
    Digitale Medien
    Seroepidemiology ofHelicobacter pylori infection in India (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 1084-1088 
    Details
    ISSN: 1573-2568
    Schlagwort(e): Helicobacter pylori ; seroepidemiology ; race ; age-specific ; socioeconomic group ; hepatitis A
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Helicobacter pylori (previouslyCampylobacter pylori) is now accepted as the major cause of type B gastritis and thus what is known about the epidemiology of type B gastritis can reasonably be transferred toH. pylori. We used a specific ELISA for anti-H. pylori IgG to study the prevalence ofH. pylori infection in a population of lower socioeconomic class from Hyderabad, India. The results from India were compared to studies from other parts of the world. Two hundred thirty-eight individuals ages 3 to 70 participated. The frequency ofH. pylori infection increased with age (P〈0.01) and was 〉80% by age 20.H. pylori infection was present in 79% of the population studied; there was no gender-related difference in prevalence ofH. pylori infection. IgG antibody against hepatitis A (HAV) was rapidly acquired in Hyderabad; in a subset of 58 children between the ages of 3 and 21 tested, the frequency of anti-HAV was 98.2%. The prevalenc ofH. pylori infection increases with age in both developed and developing countries. The high age-specific prevalence ofH. pylori infection in developing countries is probably a reflection of the lower socioeconomic level of those areas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01297451
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