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  • 1
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Keywords: Biomedical Engineering/Biotechnology ; Oncology   ; Oncology ; Oncology   ; Biomedical engineering ; Oncology ; Biomedical engineering ; Cancer research. ; Neoplasms ; Medical Oncology methods ; Biomechanical Phenomena ; Tumor Microenvironment ; Cell Physiological Phenomena ; Onkologie ; Biomechanik
    Description / Table of Contents: This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer
    Type of Medium: Online Resource
    Pages: Online-Ressource (XII, 376 p. 111 illus., 94 illus. in color, online resource)
    Edition: Springer eBook Collection. Biomedical and Life Sciences
    ISBN: 9783319952949
    Series Statement: Advances in Experimental Medicine and Biology 1092
    RVK:
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 27 (1999), S. 298-312 
    ISSN: 1573-9686
    Keywords: In vivo ; Incipient cell rolling ; Transient contact ; Drag force ; Modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The mechanics of leukocyte [white blood cell (WBC)] deformation and adhesion to endothelial cells (EC) in shear flow has been investigated. Experimental data on transient WBC–EC adhesion were obtained from in vivo measurements. Microscopic images of WBC–EC contact during incipient WBC rolling revealed that for a given wall shear stress, the contact area increases with time as new bonds are formed at the leading edge, and then decreases with time as the trailing edge of the WBC membrane peels away from the EC. A two-dimensional model (2D) was developed consisting of an elastic ring adhered to a surface under fluid stresses. This ring represents an actin-rich WBC cortical layer and contains an incompressible fluid as the cell interior. All molecular bonds are modeled as elastic springs distributed in the WBC–EC contact region. Variations of the proportionality between wall shear stress (τ w ) in the vicinity of the WBC and the resulting drag force (F s ), i.e., Fs/τw, reveal its decrease with WBC deformation and increasing vessel channel height (2D). The computations also find that the peeling zone between adherent WBC and EC may account for less than 5% of the total contact interface. Computational studies describe the WBC–EC adhesion and the extent of WBC deformation during the adhesive process. © 1999 Biomedical Engineering Society. PAC99: 8717-d, 8719Tt, 8717Aa
    Type of Medium: Electronic Resource
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