ISSN:
1573-904X
Keywords:
isoproterenol
;
cardiovascular reactivity
;
heart rate
;
pharmacodynamics
;
American Negroes
;
American Caucasians
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract It was the purpose of this study to investigate racial alterations in β-adrenoceptor response. Two groups of healthy, male volunteers gave their consent. There were eight black Americans (mean age, 26.1 ± 2.5 years) and eight white/Caucasian Americans (mean age, 24.4 ± 1.8 years). Each subject underwent an isoproterenol sensitivity test. There was a significant (P 〈 0.05) decrease in the ratio of E max to ED50 in the white group (25.3 ± 6.4) compared with the black group (37.1 ± 12.4). Over the dose range of 0.1 to 1.0 µg there was a significant increase in response at both the 0.25- and the 0.5-µg dose (P 〈 0.05), with the black American group appearing to respond with a greater rate of rise in heart rate following the initial doses.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015996929574
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