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  • 550 - Earth sciences  (3)
  • Ubiquitin  (2)
  • Alzheimer's  (1)
  • Caeruloplasmin concentration  (1)
Document type
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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 1089 (1991), S. 141-157 
    ISSN: 0167-4781
    Keywords: Development ; Neurodegenerative disease ; Ubiquitin ; Ubiquitin-mediated proteolysis ; Viral disease
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 8 (1988), S. 11-14 
    ISSN: 1437-160X
    Keywords: Caeruloplasmin concentration ; Oxidase activity ; Polyarthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Caeruloplasmin (Cp) concentration and oxidase activity have been shown to be elevated in rheumatoid arthritis (RA) and psoriatic arthritis, but normal in Reiter's syndrome, Behcet's syndrome and juvenile seronegative polyarthritis. Synovial fluid Cp was significantly depressed in comparison with serum Cp in RA. During second-line therapy in RA, Cp concentration and activity fell significantly (P〈0.001), but the change in Cp did not correlate with plasma viscosity.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0014-5793
    Keywords: Azurophilic granule ; Lysosome ; Polymorphonuclear neutrophil ; Ubiquitin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 91 (1996), S. 127-134 
    ISSN: 1432-0533
    Keywords: Key words Frontal lobe dementia ; Alzheimer's ; disease ; Pick's disease ; Corticobasal degeneration ; Motor neuron disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical features and recent developments in the neuropathology of frontotemporal dementia are reviewed. The five main neurodegenerative disorders that underlie the clinical syndrome of frontotemporal dementia are distinguished using immunohistochemistry with antisera to ubiquitin and tau proteins. Motor neuron disease-type dementia is characterised by ubiquitin-immunoreactive intraneuronal inclusions in cortical layer II and the hippocampal dentate granule cells. A diagnosis of Alzheimer's disease changes is based upon the presence of neurofibrillary tangles, which immunostain with antibodies to tau and ubiquitin, and many associated neuritic plaques. Corticobasal degeneration is diagnosed by the presence of tau-immunoreactive, but ubiquitin-non-reactive intraneuronal inclusions in cortical layer II and the substantia nigra. Pick's disease is restricted to cases with tau- and ubiquitin-immunoreactive spherical cortical intraneuronal inclusions (Pick bodies), best seen in the hippocampal dentate gyrus and frontotemporal cortex. Dementia of frontal type is the preferred term for cases in which no intraneuronal inclusions are seen with antisera to tau and ubiquitin. A practical approach to the pathological diagnosis of frontotemporal dementia and the differential diagnosis of the five disorders using immunohistochemical studies is provided.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2020-02-12
    Description: The Campanian province has a rich history of human interaction with volcanic eruptions. In a region currently inhabited by 3 million people, it is crucial to have precise and accurate geochemical characterization of volcanic units within the region so as to identify the spatial distribution of past events. Furthermore, tephrochronology is becoming an important tool in the region for correlating past environmental records. Unfortunately, many of the key units have been geochemically analysed using relatively imprecise methods, making correlation problematic. Although robust correlations have been established in the Campanian province using a range of methods, including stratigraphy and geochronology, more distal correlation requires precise geochemical characterisation of individual glass shards. Here we report major oxide data, geochemically characterising 17 key tephra units within the Campanian province using wavelength dispersive spectrometry (WDS). The new data confirm the trachytic nature of most of the eruptions. To effect more precise correlations between units (especially in distal locations), proximal units must be individually analysed for major oxides using WDS on the vitreous phase, and statistically analysed for robust correlations. In cases where similar geochemistry exists, analysis of trace and rare earth elements may be necessary.
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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  • 6
    Publication Date: 2020-02-12
    Description: Core PRAD 1-2, located on the western flank of the Mid-Adriatic Deep, contains a continuous sediment record extending back to upper MIS-11. The upper part of the record which spans the mid Holocene to MIS 5–4 (the last ca 105,000 years) has been investigated for tephra content. A total of 25 discrete tephra layers were discovered, only one of which was visible in the core sequence. The other 24 are not visible to the naked eye, nor were the majority detected by routine down-core scanning methods. A total of 625 geochemical measurements obtained from individual glass shards using WDS-EPMA enabled 21 of the 25 tephras to be assigned to known volcanic events emanating from the Campanian Province (Campi Flegrei, Somma-Vesuvius and Ischia Island). The results provide an independent basis for establishing an age–depth profile for the upper part of the PRAD 1-2 record. This study demonstrates that the number of non-visible tephra layers can significantly exceed the number of visible layers in some deep marine sequences. Routine testing for the presence of non-visible tephra layers can therefore prove rewarding, leading to the detection of additional isochrons for dating and correlating marine sequences, and for their synchronisation with terrestrial records.
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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  • 7
    Publication Date: 2020-02-12
    Description: The first part of this paper presents a review of the problems that constrain the reliability of radiocarbon-based age models with particular focus on those used to underpin marine records. The reasons why radiocarbon data-sets need to be much more comprehensive than has been the norm hitherto, and why age models should be based on calibrated data only, are outlined. The complexity of the probability structure of calibrated radiocarbon data and the advantages of a Bayesian statistical approach for constructing calibrated age models are illustrated. The second part of the paper tests the potential for reducing the uncertainties that constrain radiocarbon-based age models using tephrostratigraphy. Fine (distal) ash layers of Holocene age preserved in Adriatic prodelta sediments are analysed geochemically and compared to tephras preserved in the Lago Grande di Monticchio site in southern Italy. The Monticchio tephras have been dated both by radiocarbon and varve chronology. The importance of basing such comparisons on standardised geochemical and robust statistical procedures is stressed. In this instance, both the Adriatic and Monticchio geochemical measurements are based on wavelength dispersive spectrometry, while discriminant function analysis is employed for statistical comparisons. Using this approach, the ages of some of the Adriatic marine ash layers could be estimated in Monticchio varve years, circumventing some of the uncertainty of radiocarbon-based age models introduced by marine reservoir effects. Fine (distal) ash layers are more widespread and better preserved in Mediterranean marine sequences than realised hitherto and may offer much wider potential for refining the dating and correlation of Mediterranean marine sequences as well as marine-land correlations.
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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