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  • Neuroactive steroid  (2)
  • 162-985A; AGE; Albiespollenites spp.; Alnipollenites verus; Appendicidites spp.; Aquilapollenites spp.; Azolla spp.; Basopollis spp.; Caryapollenites simplex; Cedripites; Chenopodipollis spp.; Cicatricosisporites spp.; Compositoipollenites rhizophorus; Cupuliferoidaepollenites liblarensis; Cyclongranulates; Deltoidospora spp.; DEPTH, sediment/rock; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Ericipites spp.; Foveosporites spp.; Gleicheniidites spp.; Hydrosporis azollensis; Ilexpollenites spp.; Inaperturopollenites hiatus; Joides Resolution; Laevigatosporites spp.; Leg162; Leotrilites spp.; Lycopodiumsporites spp.; Microfoveolatosporites spp.; Milfordia foveosporites; Momipites coryloides; Monocolpollenites spp.; Norwegian Sea; Nyssapollenites spp.; Ocean Drilling Program; ODP; Osmundacidites spp.; Pandaniidites spp.; Piceapollis spp.; Pinus spp.; Pistillipollenites mcgregorii; Platycaryapollenites platycaryoides; Podocarpidites spp.; Pollen, total; Pollen indeterminata; Polyatriopollenites spp.; Polypodiaceiosporites spp.; Porocolpopollenites vestibulum; Radialisporis spp.; Retitricolpites spp.; Salixpollenites spp.; Sample code/label; Sciadopityspollenites spp.; Sequoiapollenites polyformosus; Stereisporites spp.; Striamonoletes spp.; Subtriporopollenites spp.; Tetracolporopollenites spp.; Tiliaepollenites microreticulatus; Toriosporites spp.; Triatriopollenites subtriangulus; Tricolpites spp.; Tricolporopollenites spp.; Trilites spp.; Triplanosporites spp.; Triporopollenites plektosus; Triporopollenites robustus; Triporopollenites spp.; Trudopollis spp.; Tsuga spp.; Ulmus spp.; Verrucosisporites spp.  (1)
  • 189-1172A; Carbon, organic, total; Carbonates; Coulometry; DEPTH, sediment/rock; DRILL; Drilling/drill rig; Grain size, mean; Isotope ratio mass spectrometry; Joides Resolution; Leg189; Ocean Drilling Program; ODP; Tasman Sea; δ13C, carbonate; δ18O, carbonate  (1)
Document type
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological evaluation of a modified conflict procedure: punished drinking in non-water-deprived rats (1999)
    Springer
    Psychopharmacology 145 (1999), S. 333-341 
    Details
    ISSN: 1432-2072
    Keywords: Key words Anxiolytic ; Anxiety ; Benzodiazepine ; GABAA ; 5-HT1A ; Neuroactive steroid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Conflict procedures used to detect anxiolytic-like activity of drugs often rely on maintaining strict schedules of water or food availability. It is ethically and practically desirable to reduce such states of deprivation in animal testing. Objective: The purpose of the present experiment was to develop and pharmacologically characterize a conflict drinking procedure that did not require the use of water-deprived animals. Methods: Rats were tested during daily sessions with alternating unpunished drinking (no tone: lick=sucrose solution) and signaled punished drinking (tone: lick=sucrose+shock) components, and developed individual steady baselines over a brief training period (approximately 3–4 weeks). The drugs tested i.p. were the positive allosteric modulators of γ-amino butyric acidA (GABA)A receptors, diazepam (0.03–30 mg/kg), chlordiazepoxide (0.03–30 mg/kg), lorazepam (0.03–10 mg/kg), zolpidem (0.3–10 mg/kg), pentobarbital (1–30 mg/kg), pregnanolone (1–30 mg/kg), and bretazenil (0.03– 10 mg/kg); the 5-hydroxy tryptamine1A (HT)1A-mediated anxiolytics, buspirone (1–10 mg/kg) and ipsapirone (1–17 mg/kg); and the negative controls d-amphetamine (0.3–3 mg/kg), haloperidol (0.01–0.3 mg/kg), morphine (0.3–17 mg/kg), and imipramine (0.3–30 mg/kg). Results: The experimental procedure was sensitive to increases in punished drinking by the GABAA-positive modulators, consistent with their known or putative anxiolytic activity. Further, the 5-HT1A-mediated anxiolytics increased punished drinking, although to a lesser extent and over a more narrow dose range than did the GABAergic drugs. In contrast, d-amphetamine, haloperidol, morphine, and imipramine failed to increase punished drinking up to doses that decreased unpunished drinking. Conclusions: The present results indicate that water deprivation is not a necessary condition to engender drinking conflict behavior or to obtain pharmacological effects similar to those obtained with other classical conflict procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130051066
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Positive allosteric modulators of the GABAA receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol (1999)
    Springer
    Psychopharmacology 141 (1999), S. 77-82 
    Details
    ISSN: 1432-2072
    Keywords: Key words Allopregnanolone ; Pregnanolone ; Neurosteroid ; Neuroactive steroid ; Motor behavior ; Ethanol interaction ; Benzodiazepine ; Triazolam ; Diazepam
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endogenous pregnane steroids, such as allopregnanolone (3α-hydroxy-5α-pregnan-20-one; 3α, 5α-P) and pregnanolone (3α-hydroxy-5β-pregnan-20-one; 3α,5β-P), allosterically modulate GABAA receptor function and exhibit behavioral effects similar to benzodiazepines, though acting at a distinct recognition site. Inasmuch as some positive allosteric modulators of GABAA receptor function exhibit profound interactions with ethanol, the effects of 3α,5α-P and 3α,5β-P were compared to those of two benzodiazepines, triazolam and diazepam, on the motor function of mice and rats when administered either alone or in combination with ethanol. All four test compounds exhibited dose-related impairment of motor function in the horizontal wire task in mice and the rotorod task in rats. Ethanol caused a marked enhancement of triazolam- and diazepam-induced motor impairment. In contrast, ethanol enhanced to a lesser extent the motor impairment induced by both neurosteroids in mice and not at all in rats. All four compounds increased ethanol-induced behavioral sleep time in mice, although the benzodiazepines did so at a much smaller fraction of their ataxic doses as compared to the neurosteroids. As one of the undesired side-effects of therapeutic use of benzodiazepines is their interaction with ethanol, development of neuroactive steroids as drugs may offer therapeutic advantages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050809
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Unknown
    Absolute abundances of pollen in ODP Hole 162-985A (2003)
    PANGAEA
    Details
    Publication Date: 2024-01-09
    Keywords: 162-985A; AGE; Albiespollenites spp.; Alnipollenites verus; Appendicidites spp.; Aquilapollenites spp.; Azolla spp.; Basopollis spp.; Caryapollenites simplex; Cedripites; Chenopodipollis spp.; Cicatricosisporites spp.; Compositoipollenites rhizophorus; Cupuliferoidaepollenites liblarensis; Cyclongranulates; Deltoidospora spp.; DEPTH, sediment/rock; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Ericipites spp.; Foveosporites spp.; Gleicheniidites spp.; Hydrosporis azollensis; Ilexpollenites spp.; Inaperturopollenites hiatus; Joides Resolution; Laevigatosporites spp.; Leg162; Leotrilites spp.; Lycopodiumsporites spp.; Microfoveolatosporites spp.; Milfordia foveosporites; Momipites coryloides; Monocolpollenites spp.; Norwegian Sea; Nyssapollenites spp.; Ocean Drilling Program; ODP; Osmundacidites spp.; Pandaniidites spp.; Piceapollis spp.; Pinus spp.; Pistillipollenites mcgregorii; Platycaryapollenites platycaryoides; Podocarpidites spp.; Pollen, total; Pollen indeterminata; Polyatriopollenites spp.; Polypodiaceiosporites spp.; Porocolpopollenites vestibulum; Radialisporis spp.; Retitricolpites spp.; Salixpollenites spp.; Sample code/label; Sciadopityspollenites spp.; Sequoiapollenites polyformosus; Stereisporites spp.; Striamonoletes spp.; Subtriporopollenites spp.; Tetracolporopollenites spp.; Tiliaepollenites microreticulatus; Toriosporites spp.; Triatriopollenites subtriangulus; Tricolpites spp.; Tricolporopollenites spp.; Trilites spp.; Triplanosporites spp.; Triporopollenites plektosus; Triporopollenites robustus; Triporopollenites spp.; Trudopollis spp.; Tsuga spp.; Ulmus spp.; Verrucosisporites spp.
    Type: Dataset
    Format: text/tab-separated-values, 715 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 4
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    Unknown
    Geochemical measurements of the Tasmanian Gateway from ODP Hole 189-1172A (2004)
    PANGAEA
    In:  Supplement to: Stickley, Catherine E; Brinkhuis, Henk; Schellenberg, Stephen A; Sluijs, Appy; Fuller, Michael D; Grauert, M; Röhl, Ursula; Warnaar, Jeroen; Wiliams, Graham L (2004): Timing and nature of the deepening of the Tasmanian Gateway. Paleoceanography, 19(4), PA4026, https://doi.org/10.1029/2004PA001022
    Details
    Publication Date: 2024-01-09
    Description: Tectonic changes that produced a deep Tasmanian Gateway between Australia and Antarctica are widely invoked as the major mechanism for Antarctic cryosphere growth and Antarctic Circumpolar Current (ACC) development during the Eocene/Oligocene (E/O) transition (34-33 Ma). Ocean Drilling Program (ODP) Leg 189 recovered near-continuous marine sedimentary records across the E/O transition interval at four sites around Tasmania. These records are largely barren of calcareous microfossils but contain a rich record of siliceous- and organic-walled marine microfossils. In this study we integrate micropaleontological, sedimentological, geochemical, and paleomagnetic data from Site 1172 (East Tasman Plateau) to identify four distinct phases (A-D) in the E/O Tasmanian Gateway deepening that are correlative among ODP Leg 189 sites. Phase A, prior to 35.5 Ma: minor initial deepening characterized by a shallow marine prodeltaic setting with initial condensation episodes. Phase B, 35.5-33.5 Ma: increased deepening marked by the onset of major glauconitic deposition and inception of energetic bottom-water currents. Phase C, 33.5-30.2 Ma: further deepening to bathyal depths, with episodic erosion by increasingly energetic bottom-water currents. Phase D, 〈30.2 Ma: establishment of stable, open-ocean, warm-temperate, oligotrophic settings characterized by siliceous-carbonate ooze deposition. Our combined evidence indicates that this early Oligocene Tasmanian Gateway deepening initially produced an eastward flow of relatively warm surface waters from the Australo-Antarctic Gulf into the southwestern Pacific Ocean. This "proto-Leeuwin" current fundamentally differs from previous regional reconstructions of eastward flowing cool water (e.g., a "proto-ACC") during the early Oligocene and thereby represents an important new constraint for reconstructing regional- to global-scale dynamics for this major global change event.
    Keywords: 189-1172A; Carbon, organic, total; Carbonates; Coulometry; DEPTH, sediment/rock; DRILL; Drilling/drill rig; Grain size, mean; Isotope ratio mass spectrometry; Joides Resolution; Leg189; Ocean Drilling Program; ODP; Tasman Sea; δ13C, carbonate; δ18O, carbonate
    Type: Dataset
    Format: text/tab-separated-values, 395 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
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