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  • 1
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    Online Resource
    Abdominal Fat Sonographic Measurement Compared to Anthropometric Indices for Predicting the Presence of Coronary Artery Disease
    Wiley ; 2013
    In:  Journal of Ultrasound in Medicine Vol. 32, No. 11 ( 2013-11), p. 1957-1965
    Details
    In: Journal of Ultrasound in Medicine, Wiley, Vol. 32, No. 11 ( 2013-11), p. 1957-1965
    Type of Medium: Online Resource
    ISSN: 0278-4297
    URL: Article
    DOI: 10.7863/ultra.32.11.1957
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2067124-6
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  • 2
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    Predictors of incident obesity phenotype in nonobese healthy adults
    Wiley ; 2017
    In:  European Journal of Clinical Investigation Vol. 47, No. 5 ( 2017-05), p. 357-365
    Details
    In: European Journal of Clinical Investigation, Wiley, Vol. 47, No. 5 ( 2017-05), p. 357-365
    Abstract: Despite their different cardiovascular consequences, little is known about predictors of metabolically healthy ( MHO ) and metabolically unhealthy obesity ( MUHO ). This cohort study was designed to address this question in participants of the Tehran Lipid and Glucose Study. Materials and methods Employing the Joint Interim Statement ( JIS ) metabolic syndrome criteria to define MHO / MUHO phenotypes, nonobese, otherwise healthy individuals, aged 〉  20 years ( n  = 3489) were recruited and followed up for a median of 13·4 years. Results At the follow‐up, MHO incidence rate in obese individuals was 36·6%. Comparing MHO vs. MUHO , female gender [odds ratio ( OR ) = 3·28, 95% confidence interval ( CI ) 1·27, 8·46)], increased body mass index ( BMI ; OR  = 1·32, 95% CI : 1·12, 1·60) and elevated high‐density lipoprotein cholesterol ( HDL ‐C) levels ( OR  = 1·04, 95% CI : 1·02, 1·07) were related to higher odds of incident MHO , while older age ( OR  = 0·95, 95% CI : 0·92, 0·98), increased waist circumference ( WC ; OR  = 0·86, 95% CI : 0·81, 0·91), higher WC gain ( OR  = 0·91, 95% CI : 0·87, 0·95) and increased diastolic blood pressure ( DBP ; OR  = 0·94, 95% CI : 0·91, 0·98) prevented progression towards MHO . Conclusions While baseline BMI and WC were detrimental for developing MHO vs. MUHO , gender was the strongest predictor of incident obesity phenotype in healthy nonobese individuals.
    Type of Medium: Online Resource
    ISSN: 0014-2972 , 1365-2362
    URL: Issue
    URL: Article
    DOI: 10.1111/eci.2017.47.issue-5
    DOI: 10.1111/eci.12743
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2004971-7
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  • 3
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    Risk factors, cutoff points, and definition of metabolically healthy/unhealthy obesity in children and adolescents: A scoping review of the literature
    Wiley ; 2023
    In:  Obesity Reviews Vol. 24, No. 5 ( 2023-05)
    Details
    In: Obesity Reviews, Wiley, Vol. 24, No. 5 ( 2023-05)
    Abstract: Diagnosis of metabolically healthy obesity (MHO) and its definition do not have universal criteria in the pediatric age group. Hence, this scoping review aims to identify the components, the cutoff points, and the definition of MHO in children and adolescents. A comprehensive, systematic search was conducted in PubMed, Scopus, EMBASE, and Google Scholar databases. A consensus‐based definition of MHO was developed through a Delphi process involving an international panel of 23 experts. This review included a total of 63 non‐randomized studies, published between 2007 and 2022. According to our consensus (≥80% agreement), the proposed definition for MHO included the following components: high‐density lipoprotein cholesterol 〉 40 mg/dl (or 〉 1.03 mmol/l), triglycerides ≤150 mg/dl (or ≤1.7 mmol/l), fasting plasma glucose 〈 100 mg/dl (or 〈 5.6 mmol/l), a measure of insulin, and systolic and diastolic blood pressure ≤90th percentile. Therefore, MHO was defined as the absence of the above metabolic risk factors; and those children and adolescents with one or more criteria were considered as metabolically unhealthy. A universal definition of MHO will allow comparisons between studies in the field of childhood obesity and can be useful in clinical practice.
    Type of Medium: Online Resource
    ISSN: 1467-7881 , 1467-789X
    URL: Issue
    URL: Article
    DOI: 10.1111/obr.v24.5
    DOI: 10.1111/obr.13548
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020497-8
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  • 4
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    Metabolic aspects of different phenotypes of polycystic ovary syndrome: Iranian PCOS Prevalence Study
    Wiley ; 2014
    In:  Clinical Endocrinology Vol. 81, No. 1 ( 2014-07), p. 93-99
    Details
    In: Clinical Endocrinology, Wiley, Vol. 81, No. 1 ( 2014-07), p. 93-99
    Abstract: To compare insulin resistance ( IR ) and metabolic characteristics of different phenotypes of polycystic ovary syndrome ( PCOS ) and healthy controls in a representative sample of reproductive‐aged Iranian women. Design Cross‐sectional community‐based study. Patients Of 915 participants, 136 met Rotterdam criteria for PCOS and were divided in four subgroups: ovulatory dysfunction with polycystic ovaries (Anovu +  PCO ), hyperandrogenism with PCO ( HA  +  PCO ), hyperandrogenism with ovulatory dysfunction ( HA  + Anovu) and full Rotterdam ( HA  + Anovu +  PCO ). Also 423 subjects served as normal controls, and the rest of participants were analysed as isolated HA , Anovu or PCO subgroups. Measurements Anthropometric measures, biochemical parameters and IR were compared between different groups. IR was defined using the homeostatic model assessment‐ IR ( HOMA ‐ IR ). Results Overall prevalence of IR in PCOS and normal women were 26·5% and 23·9%, respectively ( P  =   0·03). After age and BMI adjustment, there was no difference regarding metabolic characteristics between different PCOS phenotypes. Also metabolic characteristics, fasting insulin and HOMA ‐ IR were comparable in PCOS subjects with hyperandrogenism and the nonhyperandrogenic phenotype (Anovu +  PCO ). In regression analysis, only overweight and obesity ( BMI  ≥ 25 kg/m 2 ) had an independent association with IR ( OR : 2·49, CI : 1·06–5·82, P  =   0·03). Conclusions In a representative sample of an Iranian PCOS population, there is no significant difference between different PCOS phenotypes or between PCOS women and normal subjects regarding their metabolic characteristics. These findings suggest that overall metabolic screening may not always be required for all women diagnosed with PCOS . Larger‐scale population‐based studies are needed to further assess these issues.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2014.81.issue-1
    DOI: 10.1111/cen.12406
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2004597-9
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  • 5
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    Bilateral inferior petrosal sinus sampling in the differential diagnosis of ACTH‐dependent Cushing's syndrome: A reappraisal
    Wiley ; 2024
    In:  Journal of Internal Medicine
    Details
    In: Journal of Internal Medicine, Wiley
    Abstract: Cushing's syndrome (CS) is a rare disorder, once exogenous causes have been excluded. However, when diagnosed, the majority of cases are adrenocorticotropic hormone (ACTH)‐dependent, of which a substantial minority are due to a source outside of the pituitary, ectopic ACTH syndrome (EAS). Differentiating among pituitary‐dependent CS, Cushing's disease (CD) and an ectopic source can be problematic. Because non‐invasive tests in the evaluation of CS patients often lack adequate sensitivity and specificity, bilateral inferior petrosal sinus sampling (BIPSS), a minimally invasive procedure performed during the investigation of ACTH‐dependent CS, can be extremely helpful. BIPSS is considered to be the gold standard for differentiating CD from the EAS. Furthermore, although such differentiation may indeed be challenging, BIPSS is itself a complex investigation, especially in recent times due to the widespread withdrawal of corticotrophin‐releasing hormone and its replacement by desmopressin. We review current published data on this investigation and, in the light of this and our own experience, discuss its appropriate use in diagnostic algorithms.
    Type of Medium: Online Resource
    ISSN: 0954-6820 , 1365-2796
    URL: Article
    DOI: 10.1111/joim.13789
    RVK:
    XA 54380
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2006883-9
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  • 6
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    The lack of association between polycystic ovary syndrome and metabolic syndrome: Iranian PCOS prevalence study : Metabolic syndrome in PCOS subjects
    Wiley ; 2011
    In:  Clinical Endocrinology Vol. 75, No. 5 ( 2011-11), p. 692-697
    Details
    In: Clinical Endocrinology, Wiley, Vol. 75, No. 5 ( 2011-11), p. 692-697
    Type of Medium: Online Resource
    ISSN: 0300-0664
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2011.75.issue-5
    DOI: 10.1111/j.1365-2265.2011.04113.x
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2004597-9
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  • 7
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    Knowledge and attitudes of trainee physicians regarding evidence‐based medicine: a questionnaire survey in Tehran, Iran
    Wiley ; 2008
    In:  Journal of Evaluation in Clinical Practice Vol. 14, No. 5 ( 2008-10), p. 775-779
    Details
    In: Journal of Evaluation in Clinical Practice, Wiley, Vol. 14, No. 5 ( 2008-10), p. 775-779
    Abstract: Rationale, aims and objectives  Knowledge in evidence‐based medicine (EBM) is increasingly becoming a core competence in medical education. We evaluated the trainee doctors’ attitudes and knowledge of EBM to obtain the basis required for developing appropriate teaching and learning opportunities. Methods  Trainee physicians at a Tehran University hospital were surveyed. The questionnaire included six questions evaluating knowledge of EBM, the number of correct answers yielding the knowledge score, and eight questions evaluating attitudes towards EBM. Participants were also asked to mark on a 10‐cm Visual Analogue Scale their use of various information sources and tendency to participate in EBM training courses. Results  The response rate was 80% (104/130). The mean knowledge score was 3 ± 1.3 (SD) on a range of 0–6 for all respondents and was not significantly different between interns (2.9 ± 1.4) and postgraduates (3.3 ± 1.0). Forty one per cent of interns and 66% of postgraduates had a positive attitude towards EBM; the remaining respondents were neutral. Textbooks and consulting experts were the most, and Cochrane Library was the least, used sources of information among both interns and postgraduates. The knowledge score was not associated with attitude, but was higher in those with previous research experience, prior EBM training, or the postgraduates that read more articles. The postgraduates and those with prior EBM training showed a significantly more positive attitude towards EBM. Conclusion  The present study demonstrates that the majority of trainee physicians at a Tehran University hospital lack adequate knowledge about basic concepts of EBM. Furthermore, most of them continue to use traditional sources of knowledge rather than evidence‐based sources. On the positive side, there was an overall positive attitude towards EBM and the majority had a positive tendency to take part in EBM training courses.
    Type of Medium: Online Resource
    ISSN: 1356-1294 , 1365-2753
    URL: Issue
    URL: Article
    DOI: 10.1111/jep.2008.14.issue-5
    DOI: 10.1111/j.1365-2753.2008.01073.x
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2006772-0
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  • 8
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    Changes in waist circumference and incidence of chronic kidney disease
    Wiley ; 2014
    In:  European Journal of Clinical Investigation Vol. 44, No. 5 ( 2014-05), p. 470-476
    Details
    In: European Journal of Clinical Investigation, Wiley, Vol. 44, No. 5 ( 2014-05), p. 470-476
    Abstract: Many studies have evaluated the association of anthropometric indices with chronic kidney disease( CKD ), but the association of waist circumference( WC ) changes with CKD incidence is less clear. We evaluated the effect of WC changes on CKD incidence in participants of the T ehran L ipid and G lucose S tudy( TLGS ). Study design The risk of CKD incidence was evaluated in three serial phases with interval censoring. A group of 8,183 (46·5% men) participants, mean age 47·4 years, free of previous CKD , were followed. Waist changes were divided into four groups: (i)decrease in WC ; (ii) reference group; (iii)mild to moderate increase in WC and (iv)severe increase in WC . G lomerular filtration rate( GFR ) was estimated using the MDRD equation. Results In 8,183 participants, mean GFR was higher in men (77·1 vs. 74·4  mL /min/1·73 m 2 , P   〈   0·001). During the 9 years of follow‐up, 1477 new cases of CKD occurred(1026 in women). WC changes were not associated with the development of CKD in women. In men, decrease in WC was not related to lower risk of CKD ( HR : 0·90, 95% CI 0·6–1·4), whereas a mild to moderate increase in WC was associated with a 70% ( HR : 1·7, 95% CI 1·3–2·2) higher risk of CKD even after adjusting for covariates ( HR : 1·6, 95% CI 1·2–2·2). Severe increase in WC was associated with a fourfold risk of CKD in comparison with reference group ( HR : 3·7, 95% CI 2·7–5·1). Conclusion Changes in WC are not independent risk factors for CKD development in women, whereas waist gain can adversely influence the development of CKD in men.
    Type of Medium: Online Resource
    ISSN: 0014-2972 , 1365-2362
    URL: Issue
    URL: Article
    DOI: 10.1111/eci.2014.44.issue-5
    DOI: 10.1111/eci.12253
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2004971-7
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  • 9
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    Is persistence of metabolic syndrome associated with poor health‐related quality of life in non‐diabetic Iranian adults? Tehran Lipid and Glucose Study
    Wiley ; 2014
    In:  Journal of Diabetes Investigation Vol. 5, No. 6 ( 2014-11), p. 687-693
    Details
    In: Journal of Diabetes Investigation, Wiley, Vol. 5, No. 6 ( 2014-11), p. 687-693
    Abstract: Previous research showed the association between health‐related quality of life and metabolic syndrome (MetS). The present study aimed to examine the impact of persistence of MetS on health‐related quality of life in non‐diabetic Iranian adults. Materials and Methods This was a cross‐sectional study. A representative sample of 643 non‐diabetic individuals (67% female), aged ≥20 years, who participated in the Tehran Lipid and Glucose Study in 2005–2007 were recruited for the study, and categorized into four groups, those without, with transient, with intermittent and with persistent MetS. Health‐related quality of life was assessed using the Iranian version of the Short Form Health Survey. MetS was diagnosed using the Joint Interim Statement criteria. Results Women with transient, intermittent and persistent MetS scored lower on the Physical Component Summary than those without the syndrome (51.03 ± 1.41, 48.16 ± 1.46 and 46.58 ± 1.29 vs 52.18 ± 1.20) after adjusting for potential confounders ( P  = 0.04). In women, there was also a significant decreasing trend in the scores of bodily pain ( P for trend = 0.006) and general health ( P for trend = 0.005) across the study groups. Compared with women without MetS, the odds ratio of reporting poor health‐related quality of life for women with intermittent MetS was 2.75 (95% confidence interval 1.19–6.37, P  = 0.01). Among men, however, no significant difference was observed in any of the health‐related quality of life domains. Conclusions Compared with women without, with transient and with persistent MetS, those with intermittent MetS reported poorer physical health‐related quality of life.
    Type of Medium: Online Resource
    ISSN: 2040-1116 , 2040-1124
    URL: Issue
    URL: Article
    DOI: 10.1111/jdi.2014.5.issue-6
    DOI: 10.1111/jdi.12222
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2542077-X
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  • 10
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    Predictive value of body mass index and waist circumference for metabolic syndrome in 6-12-year-olds : Metabolic syndrome predictors in children
    Wiley ; 2011
    In:  Acta Paediatrica Vol. 100, No. 5 ( 2011-05), p. 722-727
    Details
    In: Acta Paediatrica, Wiley, Vol. 100, No. 5 ( 2011-05), p. 722-727
    Type of Medium: Online Resource
    ISSN: 0803-5253
    URL: Issue
    URL: Article
    DOI: 10.1111/apa.2011.100.issue-5
    DOI: 10.1111/j.1651-2227.2011.02162.x
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1492629-5
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