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  • Universitas Gadjah Mada  (3)
  • 1
    Online Resource
    Online Resource
    Peningkatan Aktivitas Antioksidan Superoksida Dismutase pada Tikus Hiperglikemi dengan Asupan Tempe Koro Benguk (Mucuna pruriens L.)
    Universitas Gadjah Mada ; 2013
    In:  agriTECH Vol. 33, No. 2 ( 2013-08-23)
    Details
    In: agriTECH, Universitas Gadjah Mada, Vol. 33, No. 2 ( 2013-08-23)
    Abstract: Hyperglycemia is associated with oxidative stress and the pathogenesis of diabetic complications. To reduce the hyperglycemia, modern treatment combined with traditional therapies through functional foods need to be considered, particularly to repair the damaged pancreas beta cells. A foodstuff that has a functionality potential is velvet beans (Mucuna pruriens L), espcially when it is in the form of a fermented product, i.e. tempe. The aim of study was to prove the effect of velvet beans tempe intake on blood glucose levels and superoxide dismutase antioxidant status. This research used randomized controlled group pre test- post test design using 50 male Sprague Dawley (SD) rats aged 2-3 months. The rats were subdivided into 5 groups, 10 rats per group, by means of random allocation. Group 1 is negative control (C-), group 2 is positive control (C+), group 3 is X1-TK10%, group 4 is X2-TK20%, group 5 is X3-TK30%. The groups of C+,X1, X2, X3 are induced by 40 mg/kg body weight stereptozotocin dose by intra peritoneal injection. The research was conducted for 30 days. The data were analyzed with Paired T Test, One-way Anova and continued by the Duncan’s Multiple Range Test. The results showed that streptozotocin injection increased the level of blood glucose and reduced the level of serum superoxide dismutase antioxidant activity. Bioassay experiment demonstrated that velvet bean tempe diet reduced the level of blood glucose. On the other hand velvet bean tempe diet improved the level of superoxide dismutase antioxidant activity.ABSTRAKHiperglikemi menimbulkan stress oksidatif dan patogenesis komplikasi diabetes. Untuk menurunkan hiperglikemi perlu dipertimbangkan kombinasi antara pengobatan modern dengan terapi tardisional melalui pangan fungsional guna mengurangi kerusakan sel beta pankreas. Bahan pangan yang memiliki potensi fungsional tersebut adalah biji koro benguk (Mucuna pruriens L) yang difermentasi menjadi bentuk tempe. Tujuan dari penelitian ini adalah untuk membuktikan pengaruh asupan tempe koro benguk terhadap kadar glukosa darah dan status antioksidan serum pada tikus hiperglikemi. Penelitian ini menggunakan 50 ekor tikus jantan jenis Sprague Dawley umur 2-3 bulan. Tikus dibagi ke dalam 5 kelompok dengan cara random alokasi. Kelompok 1 kontrol negatif (C-), kelompok 2 kontrol positif (C+), kelompok 3 adalah X1-TK10%, kelompok 4 adalah X2-TK10%, kelompok 5 adalah X3-TK10%. Tikus kelompok C+, X1, X2, X3 diinduksi streptozotocin (STZ) dengan dosis 40 mg/kg BB secara inta peritoneal. Penelitian dilakukan selama 30 hari. Data dianalisis dengan Paired T test, One way Anova dan dilanjutkan dengan Uji Wilayah Ganda Duncan. Hasil penelitian menunjukkan bahwa STZ meningkatkan kadar glukosa darah dan menurunkan aktivitas antioksidan SOD serum. Hasil analisis in vivo pada tkus menunjukkan bahwa asupan tempe koro benguk menurunkan kadar glukosa darah dan meningkatkan aktivitas antioksidan SOD serum. 
    Type of Medium: Online Resource
    ISSN: 2527-3825 , 0216-0455
    URL: Article
    DOI: 10.22146/agritech.9803
    Language: Unknown
    Publisher: Universitas Gadjah Mada
    Publication Date: 2013
    detail.hit.zdb_id: 2974874-4
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  • 2
    Online Resource
    Online Resource
    Pemberian kombinasi probiotik dan zinc terhadap perubahan kadar hemoglobin, albumin, dan indeks massa tubuh pada pasien tuberkulosis paru
    Universitas Gadjah Mada ; 2016
    In:  Jurnal Gizi Klinik Indonesia Vol. 13, No. 1 ( 2016-07-30), p. 7-
    Details
    In: Jurnal Gizi Klinik Indonesia, Universitas Gadjah Mada, Vol. 13, No. 1 ( 2016-07-30), p. 7-
    Abstract: Background: TB patients are generally the most productive age group and suffer from chronic energy deficiency. Therefore, patients with TB requires a combination of chemotherapy and supplementary feeding as probiotics and zinc to boost the immune response and nutritional status.Objective: To analyze the effect of a combined of probiotics and zinc on the changes of hemoglobin, albumin level, and BMI.Method: This study is a quasi-experimental, randomized design with pre-post test control group involving 52 respondents. They were divided into two groups. The treatment group was given a combination of 1 capsule of probiotics (2 billion probiotics) and zinc 20 mg per day for 28 days. The analysis is paired t-test, independent t-test, Mann-Whitney, Pearson, Spearman, Covariance.Results: There was an increase in hemoglobin (p=0.01), albumin (p=0.01) and BMI (p=0.01). There is no difference between the two groups in the levels of hemoglobin parameter (p=0.21) and BMI (p=0.12), whereas there is a difference parameter albumin levels (p=0.01). The effectiveness of interventions is 4% for hemoglobin levels, 16% to albumin, and 1% for IMT.Conclusion: Probiotics and zinc for 28 days in patients with pulmonary tuberculosis may increase levels of hemoglobin, albumin, and BMI, but there is no significant difference in the changes of BMI. The most powerful influence of intervention effectiveness is on albumin.
    Type of Medium: Online Resource
    ISSN: 2502-4140 , 1693-900X
    URL: Article
    DOI: 10.22146/ijcn.23024
    Language: Unknown
    Publisher: Universitas Gadjah Mada
    Publication Date: 2016
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  • 3
    Online Resource
    Online Resource
    Characterization of Chitosan-Based Active Film with Addition of Young Coconut (Cocos nucifera) Leaf Extract
    Universitas Gadjah Mada ; 2022
    In:  agriTECH Vol. 42, No. 3 ( 2022-09-06), p. 283-
    Details
    In: agriTECH, Universitas Gadjah Mada, Vol. 42, No. 3 ( 2022-09-06), p. 283-
    Abstract: This research was aimed to investigate the potential of young coconut (Cocos nucifera L.) leaf extract as an antioxidant and antibacterial active compounds. In this study, the physical, mechanical, antioxidant, and antibacterial activity of chitosan-based film with addition of young coconut leaf extract were examined. The young coconut leaf extract was prepared by maceration using ethanol for 48 hours at room temperature. The antioxidant and antibacterial activities were determined by the DPPH and well diffusion methods, respectively. The total phenolic and flavonoids were analyzed using spectrophotometric method. The film was prepared using 1.0 and 1.5% chitosan solution added with young coconut leaf extract at 0, 0.1, and 0.3%. The characterization of the film included color, tensile strength, elongation, WVP, film morphology, identification of functional groups, and total phenolic and antioxidant activity release. The results showed that the antioxidant activity of young coconut leaf extract was IC50 of 58.61 ppm. The antibacterial activity test showed that the inhibitory zone for S. aureus, Salmonella sp., and E. coli were 17,66, 24.40, and 12.27 mm, respectively. Total phenolic and flavonoid contents were 129.27 mg GAE/g extracts and 3.92 mg QE/g extract, respectively. The color of the film was dark. The higher the concentration of chitosan and the young coconut leaf extract, the higher the tensile strength, whereas the value of elongation at break and water vapor permeability decreased. The release of total phenolic was higher in lipophilic food simulants than in an aqueous system. The result of the study reveals that chitosan-based film added with young coconut leaf extract had great potential as an active biodegradable film for food packaging systems. 
    Type of Medium: Online Resource
    ISSN: 2527-3825 , 0216-0455
    URL: Article
    DOI: 10.22146/agritech.64181
    Language: Unknown
    Publisher: Universitas Gadjah Mada
    Publication Date: 2022
    detail.hit.zdb_id: 2974874-4
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