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  • 1
    Electronic Resource
    Electronic Resource
    Vinyltrimethylsilane-co-N-vinyl-2-pyrrolidone and vinyltrimethoxysilane-co-N-vinyl-2-pyrrolidone copolymers Synthesis and reactivity ratios (1998)
    Springer
    Polymer bulletin 40 (1998), S. 707-713 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Copolymers containing vinyltrimethylsilane and vinyltrimethoxysilane with N-vinyl-2-pyrrolidone at different compositions were synthesized and characterized. The reactivity ratios was estimated by using the classical Fineman-Ross and Kelen Tüdos linear fitting procedures. These parameters were also estimated through a computer program based on nonlinear minimization algorithm, starting from the r1 and r2 values obtained by the former procedures. The analysis of the results allow us to interpret the reactivity behaviour of these polymers in terms of the relative reactivity of the substiuents. The effect of the chemical structure of the polymer side group is discussed in terms of the different contributions to the stabilization of the radical intermediates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002890050312
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  • 2
    Electronic Resource
    Electronic Resource
    p,p′-DDT is an estrogenic compound (1988)
    Springer
    Bulletin of environmental contamination and toxicology 41 (1988), S. 496-501 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02020992
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  • 3
    Electronic Resource
    Electronic Resource
    Hepatic dysfunction due to parvovirus B19 infection (2000)
    Springer
    Journal of infection and chemotherapy 6 (2000), S. 63-64 
    Details
    ISSN: 1437-7780
    Keywords: Key words Parvovirus B19 ; Acute hepatitis ; Adult ; Liver function tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Parvovirus B19 has been associated with different diseases. However, hepatic involvement has rarely been reported in adult patients with parvovirus B19 infection. Herein, we report two adult patients with hepatic dysfunction associated with acute parvovirus B19 infection. We believe that hepatic involvement in the setting of parvovirus B19 infection is more common than suspected, and that antibodies against this agent should be routinely measured in patients with hepatic dysfunction of unclear etiology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101560050052
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  • 4
    Electronic Resource
    Electronic Resource
    Pericyte endothelial gap junctions in human cerebral capillaries (1984)
    Springer
    Anatomy and embryology 170 (1984), S. 155-159 
    Details
    ISSN: 1432-0568
    Keywords: Human cerebral capillaries ; Pericytes ; Endothelium ; Gap junctions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human cerebral tissue has been ultrastructurally studied and gap junctions have been visualized between endothelial cells and pericytes that permit ion exchange. We propose that the functional interrelationship between endothelium and pericytes may play a role in the alteration of capillary diameter for the control of local cerebral blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319000
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  • 5
    Electronic Resource
    Electronic Resource
    Cerebral cortex blood flow and vascular smooth muscle contractility in a rat model of ischemia: a correlative laser Doppler flowmetric and scanning electron microscopic study (1997)
    Springer
    Acta neuropathologica 93 (1997), S. 354-368 
    Details
    ISSN: 1432-0533
    Keywords: Key words Reperfusion ; Cerebral blood flow ; Vascular smooth muscle cell ; Pericyte ; Scanning ; electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was undertaken to ascertain the role of smooth muscles and pericytes in the microcirculation during hyperperfusion and hypoperfusion following ischemia in rats. Paired external carotids, the pterygopalatine branch of the internal carotids and the basilar artery were exposed and divided. Reversible inflatable occluders were placed around the common carotids. After 24 h, the unanesthetized rat underwent 10-min ischemia by inflating the occluders. Continuous cortical cerebral blood flow (c-CBF) was monitored by laser Doppler flowmetry. The measured c-CBF was below 20% of control (P 〈 0.001) during ischemia. A c-CBF of 227.5 ± 54.1% (P 〈 0.001) was obtained during reperfusion hyperemia. A c-CBF of 59.7 ± 8.8% (P 〈 0.001) occurred at the nadir of postischemic hypoperfusion, and this was followed by a second hyperemia. The cytoarchitecture of the vascular smooth muscles and pericytes was assessed by scanning electron microscopy. Samples were prepared using a KOH-collagenase digestion method. In control rats, arteriolar muscle cells showed smooth surfaces. Capillary pericytes were closely apposed to the endothelium. Immediately after reperfusion, transverse membrane creases were observed on the smooth muscle surfaces. During maximal hyperemia the creases disappeared. When c-CBF started to decrease the creases became visible again. Throughout the postischemic hypoperfusion the creases remained. Capillary endothelial walls became tortuous in the late phase of hypoperfusion. During the second hyperemia most arteriolar muscle cells showed smooth surfaces. Some pericytes appeared to have migrated from the vascular wall. The morphological changes of smooth muscle membranes suggest that they are related to specific perfusional disturbances during ischemia and reperfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050627
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  • 6
    Electronic Resource
    Electronic Resource
    Spontaneous dissecting aneurysm of the common iliac artery (1991)
    Springer
    Annals of vascular surgery 5 (1991), S. 549-551 
    Details
    ISSN: 1615-5947
    Keywords: Iliac artery, common ; claudication ; aneurysm ; peripheral vascular disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 52-year-old man sought medical advice for sudden onset of intermittent claudication of the left lower limb after 50 meters walking. Aortography documented a dissecting aneurysm limited to the left common iliac artery. After resection, a prosthetic graft was inserted. Pathology showed that the cause of the dissection was atheroma. Spontaneous dissecting aneurysm of the common iliac artery is rare. Rupture represents the principal hazard. A high index of suspicion should lead to diagnosis as soon as signs of lower limb ischemia, occasionally transient, appear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02015282
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  • 7
    Electronic Resource
    Electronic Resource
    New formulas for the calculation of effective renal plasma flow (1982)
    Springer
    European journal of nuclear medicine 7 (1982), S. 51-54 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Estimation of effective renal plasma flow (ERPF) can be made easily, inexpensively, and accurately by means of a single plasma concentration determination, sampled 44 min after injection of 131I-orthoiodohippurate (OIH). We originally established predictive regression equations based on a series of patients with a wide variety of diseases and a few normal potential kidney donors. The equation best fitting that data was parabolic in form and assumed a negative slope when high ERPF rates were encountered. This problem has been corrected by deriving new equations (parabolic and exponential) based on an expanded series which includes a large number of subjects with high ERPF. Errors of estimation are lower than those of the more classic para-aminohippuric acid (PAH) clearances and well within the exigencies of clinical practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251641
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  • 8
    Electronic Resource
    Electronic Resource
    Radiosurgery for Cerebral Arteriovenous Malformations (1998)
    Springer
    Journal of radiosurgery 1 (1998), S. 225-231 
    Details
    ISSN: 1573-8752
    Keywords: Arteriovenous malformation ; γ knife ; LINAC ; radiosurgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract From September 1991 to May 1997, a total of 59 patients diagnosed with cerebral arteriovenous malformations were treated using radiosurgery. There were 29 men and 30 women, with an age range of 5 to 75 years (mean 36). Of these patients, 39 patients were treated using a LINAC-based system (group 1) and 20 using the Leksell γ-knife unit (group 2). Tumor volume ranged from 0.38 to 35 cc, and the number of isocenters varied from 1 to 3 in group 1 and from 2 to 15 in group 2. Lesion location was as follows: 14 temporal, 8 basal ganglionic, 8 frontal, 6 parietal, 6 thalamic, 5 intraventricular, 5 cerebellar, 3 brain stem, 3 occipital, and 1 corpus callosal. Seven patients underwent prior embolization and three patients had prior surgery with incomplete resection of their lesions. The marginal radiation dose ranged between 1500 and 2000 cGy with a mean of 1800 cGy. Twelve patients had concomitant embolization done on the morning of radiosurgery. Follow-up ranged from 1 month to 4 years. Thirty-six patients have been followed for more than 1 year. Thirty had an angiography during the follow-up period that showed complete obliteration of the lesion in 28 patients. The rate of obliteration was estimated to be 47.1% at 1 year, 82.3% at 2 years and 88.2% at 3 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:JORA.0000015198.05410.96
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  • 9
    Electronic Resource
    Electronic Resource
    γ-Knife Radiosurgery for Brainstem Lesions: The Wayne State University Experience (1999)
    Springer
    Journal of radiosurgery 2 (1999), S. 135-139 
    Details
    ISSN: 1573-8752
    Keywords: Brainstem ; stereotactic radiosurgery ; γ-knife ; performance status
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Stereotactic radiosurgery (SRS) is increasingly being used for tumors of the brainstem because it suits the anatomical constraints of this area. We now report on the 2-year experience at Wayne State University using γ-knife SRS for such lesions, with an emphasis on toxicity and morbidity. From January 1996 to January 1998, sixteen patients (6 males and 10 females) with lesions in the area of the brainstem were treated with SRS. Average age was 53 years (range 19–80). Nine lesions were malignant; 7 were benign. Median Karnofsky performance status (KPS) prior to SRS was 80 (range 50–100). Median follow-up period from initial diagnosis to analysis, and from the date of SRS to analysis, was 24 months (range 11–73) and 15 months (range 4–29), respectively. Results were analyzed for the whole population treated and then stratified by diagnosis: benign versus malignant. At analysis, 10 (62.6%) patients were alive and 6 (37.5%) were dead. No deaths followed SRS. Values for KPS prior to SRS were compared to 3 months post-SRS. No significant change in KPS scores could be observed for those with benign lesions, but 67% of patients with malignant tumors showed a KPS drop ≥30 points. There was no correlation between the treated volume and survival. At the time of review, no patients had developed new neurological symptoms after SRS. Results for benign lesions indicate that SRS is well tolerated, provides good local control, and does not cause unusual rates of morbidity or mortality. Results for malignant lesions demonstrate that pretreatment performance status influences the post-SRS values. The post-SRS Median Survival (MS) of 10 months for the Malignant Lesions (M) is impressive, in light of the drop of KPS observed; the outcome for such patients is likely determined by the activity of the primary disease process. Our results suggest that SRS in the brainstem is safe, feasible, and merits further study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022966629467
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  • 10
    Electronic Resource
    Electronic Resource
    Permanent Iodine-125 Implants in the Treatment of Low-Grade Gliomas (2000)
    Springer
    Journal of radiosurgery 3 (2000), S. 147-154 
    Details
    ISSN: 1573-8752
    Keywords: Brachytherapy ; implants ; iodine-125 ; low-grade glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a retrospective study on the use of the permanent iodine-125 (125I) implants in the management of low-grade gliomas. From July 1988 to July 1997, 16 patients with low-grade gliomas underwent permanent 125I implants in the management of their lesions. There were 7 males and 9 females ranging in age from 4 to 48 years (mean 19). The location was in the cerebral hemisphere in 7 patients, brainstem in 5 patients and thalamus/basal ganglia in 4 patients. Prior to brachytherapy, 9 patients underwent surgical resection and 7 patients underwent stereotactic biopsy procedures. Fourteen patients were treated as part of the initial management and 2 were recurrent. The histological diagnosis was: 9 WHO grade II astrocytomas, 3 oligodendrogliomas, 2 gemistocytic astrocytomas, 1 pilocytic astrocytoma, and 1 ependymoma. The tumor volume ranged from 0.7 to 33.4 cc (mean 8.4). Stereotactic treatment planning was used to encompass the contrast-enhancing rim of the tumor visualized by computerized tomography with an initial dose rate of 0.05 Gy/hour with 125I. The total activity ranged from 0.8 to 20.5 mCi. With a median follow-up period of 35 months (range, 4–105 months), the 2- and 5-year survival rates were 93.7% and 87.5%, respectively. Three patients underwent reoperation after implants, two of three had recurrent disease, and one had radiation necrosis. Permanent 125I implants appear to be safe and effective as a part of the multimodality management of low-grade gliomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009521329633
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