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  • 1
    Electronic Resource
    Electronic Resource
    Zur Frage der physikalisch-chemischen Charakterisierung der Protein (1926)
    Springer
    Naturwissenschaften 14 (1926), S. 487-488 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01507529
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  • 2
    Electronic Resource
    Electronic Resource
    Responsiveness of cardiac Na+ channels to a site-directed antiserum against the cytosolic linker between domains III and IV and their sensitivity to other modifying agents (1993)
    Springer
    The journal of membrane biology 134 (1993), S. 231-239 
    Details
    ISSN: 1432-1424
    Keywords: Noninactivating cardiac Na+ channels ; Removal of inactivation ; Cardiac Na+ channel protein ; α-subunit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Elementary Na+ currents were recorded in inside-out patches from neonatal rat heart cardiocytes to analyze the influence of a site-directed polyclonal anti-serum against the linker region between the domains III and IV (amino acids 1489–1507 of the cardiac Na+ channel protein) on Na+ channel gating and to test whether this part of the α-subunit may be considered as a target for modifying agents such as the (−)-enantiomer of DPI 201-106. Anti-SLP 1 serum (directed against amino acids 1490–1507) evoked, usually within 10–15 min after cytosolic administration, modified Na+ channel activity. Antiserum-modified Na+ channels retain a single open state but leave, at −60 mV for example, their conducting configuration consistently with an about threefold lower rate than normal Na+ channels. Another outstanding property of noninactivating Na+ channels, enhanced burst activity, may be quite individually pronounced, a surprising result which is difficult to interpret in terms of structure function relations. Removal of inactivation led to an increase of reconstructed peak I Na (indicating a rise in NP o) and changed I Na decay to obey second-order kinetics, i.e., open probability declined slowly but progressively during membrane depolarization. The underlying deactivation process is voltage dependent and responds to a positive voltage shift with a deceleration but may operate even at the same membrane potential with different rates. Iodatemodified Na+ channels exhibit very similar properties including a conserved conductance. They are likewise controlled by an efficient, voltage-dependent deactivation process. Modification by (−)-DPI 201-106 fundamentally contrasts to the influence of anti-SLP 1 serum and the protein reagent iodate since (−)-DPI-modified Na+ channels maintain their open probability for at least 120 msec, i.e., a deactivation process seems lacking. This functional difference suggests that the linker region between the domains III and IV of the α-subunit may not be the only target for (−)-DPI 201-106 and related compounds, if at all.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234504
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  • 3
    Electronic Resource
    Electronic Resource
    Adjuvant chemotherapy in osteosarcoma — Effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 1-7 
    Details
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Preoperative chemo-therapy ; Limb salvage ; High dose methotrexate ; Interferon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a cooperative adjuvant chemotherapy study of osteosarcoma (COSS-80), 192 patients were registered from December 1979 to March 1982. Fortyone patients have been excluded from study because of their nonadjuvant situation, therapy-limiting clinical conditions, or inadequate diagnosis. One hundred and fifty-one patients have been randomized to receive either the drug combination bleomycin+cyclophosphamide+dactinomycin (BCD) or cisplatinum (CPL) within a course of sequential multidrug chemotherapy including adriamycin (ADR) and high dose methotrexate (HDMTX). After exclusion of 51 patients with some deviation in history and/or management 100 selected patients were randomized once more to receive in addition or not fibroblast interferon after preoperative chemotherapy and surgical removal of the primary tumor. Patients were stratified for age and sex and for site and extension of tumor as well in both randomizations. Median follow up is now 12 (1–16) months. The expected 2-year disease free survival (DFS) rate of the total doubly randomized group is 78% and of the single randomized group 76%. No difference could be discerned between recombined groups receiving BCD vs CPL or interferon vs no interferon. The effect of preoperative chemotherapy on the tumor was evaluated clinically and by histopathologic grading; 66/85 (78%) patients were judged clinically as responders with pathohistologic verification of this finding in 71% of these cases. No adverse effect arose from delaying definite surgery for preoperative chemotherapy, but initial application of chemotherapy as well as planning, preparing, and performing of the surgical procedure have been facilitated. The majority of patients received some kind of limb-salvage treatment without local recurrences so far. A statistically insignificant but intriguing tendency for a slightly higher incidence of pulmonary metastases after resection as opposed to amputation could be detected. Similar to observations in the previous study COSS-77.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00625042
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  • 4
    Electronic Resource
    Electronic Resource
    Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 257-261 
    Details
    ISSN: 1420-9071
    Keywords: Aspirin-like drugs ; flurbiprofen enantiomers ; anti-inflammatory ; analgesic ; gastrointestinal toxicity ; prostaglandin synthesis ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Using flurbiprofen, a chiral anti-inflammatory and analgesic 2-arylpropionic acid derivative, the enantiomers of which are not converted to each other (less than 5%) in rats or man, we obtained evidence that prostaglandin synthesis inhibition is primarily mediating the anti-inflammatory activity but prostaglandin synthesis independent mechanisms contribute to the analgesic effects. Thus, the S-form inhibited prostaglandin synthesis, inflammation and nociception in rats. The R-form had much less effect on prostaglandin synthesis and did not affect inflammation. It did, however, block nociception in rats almost as potently as the S-form. S-flurbiprofen, in contrast to the R-form, was clearly ulcerogenic in the gastrointestinal mucosa. These results indicate additional molecular mechanisms of analgesia and suggest the use of R-arylpropionic acids as analgesics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958153
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  • 5
    Electronic Resource
    Electronic Resource
    External-field-dependent enhancement of internal Coulomb interactions in time-resolved four-wave mixing (1995)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 17 (1995), S. 1355-1358 
    Details
    ISSN: 0392-6737
    Keywords: Time-resolved optical phenomena (including electron-hole drops) ; Optical properties of thin films surfaces, and layer structures (superlattices, heterojunctions and multilayers) ; Electron states in low-dimensional structures (including quantum wells, superlattices, layer structures, and intercalation compounds) ; Conference proceedings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary We show that a detailed understanding of the influence of the exciton-exciton interaction on the non-linear excitonic response in a GaAs/AlGaAs superlattice can be obtained by changing the external applied field. In time-resolved four-wave mixing this implies a change from a third-order polarization signal dominated by phase space occupation to a Coulomb interaction-induced signal when the bias is increased at high excitation densities. The experimental data are compared with theoretical results based on the numerical solution of the semiconductor Bloch equations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02457209
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  • 6
    Electronic Resource
    Electronic Resource
    Two types of modified cardiac Na+ channels after cytosolic interventions at the α-subunit capable of removing Na+ inactivation (1997)
    Springer
    European biophysics journal 25 (1997), S. 189-200 
    Details
    ISSN: 1432-1017
    Keywords: Key words Single cardiac Na+ channels ; Site-directed antipeptide antibody ; Proteolysis ; Protein reagents ; Calpain ; Stochastic mode switching
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Failure of inactivation is the typical response of voltage-gated Na+ channels to the cytosolic presence of proteolytic enzymes, protein reagents such as N-bromoacetamide (NBA) or iodate, and antibodies directed against the linker between domains III and IV of the α-subunit. The present patch clamp experiments with cardiac Na+ channels aimed to test the hypothesis that these interventions may provoke the occurrence of non-inactivating Na+ channels with distinct kinetic properties. A site-directed polyclonal antibody (anti-SLP2, target sequence 1481–1496 of the cardiac Na+ channel α-subunit) eliminated fast Na+ inactivation to induce burst activity which was accompanied by the occurrence of two open states. A deactivation process terminated channel activity during membrane depolarization proceeding with time constants of close to 40 ms (at –40 mV). NBA-modified and iodate-modified Na+ channels were kinetically indistinguishable from the anti-SLP2-modified type since they likewise deactivate and, thus, attain an only moderate Po of close to 20%. This is fundamentally different from the behaviour of enzymatically-modified Na+ channels: after cytosolic proteolysis with α-chymotrypsin, trypsin or pronase, mean Po during membrane depolarization amounted to approximately 40% because deactivation operated extremely slowly and less efficiently (time constants 100–200 ms at –40 mV, as a minimum) or was virtually non-operating. In-vitro cleavage of the synthetic linker sequence 1481–1496 confirmed that this part of the α-subunit provides a substrate for these peptidases or reactants for NBA but cannot be chemically modified by iodate. This iodate resistance indicates that iodate-modified Na+ channels are based on a structural alteration of still another region which is also involved in Na+ inactivation, besides the linker between domains III and IV of the α-subunit. Endogenous peptidases such as calpain did not affect Na+ inactivation. This stresses the stochastic nature of a kinetic peculiarity of cardiac Na+ channels, mode-switching to a non-inactivating mode.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002490050031
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  • 7
    Electronic Resource
    Electronic Resource
    Transient secondary hypothyroidism and thyroxine binding globulin deficiency in leukemic children during polychemotherapy: An effect of L-asparaginase (1981)
    Springer
    European journal of pediatrics 136 (1981), S. 291-295 
    Details
    ISSN: 1432-1076
    Keywords: Acute lymphoblastic leukemia ; Hypothyroidism ; L-asparaginase ; Thyroxine binding globulin ; Thyroid hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently it has been observed that L-asparaginase causes transient thyroxine binding globulin (TBG) deficiency in adults. In the present study we investigated the influence of L-asparaginase on the pituitary-thyroid axis and on the synthesis of TBG. 14 children with acute lymphoblastic leukemia were treated with a combination of L-asparaginase, vincristine, prednisone and daunomycin for remission induction. Thyroid function was monitored by measuring total T4, free T4, total T3, TSH and TBG with specific radioimmunoassays before, during and after treatment. Within 3 weeks of L-asparaginase therapy total T4 fell significantly from 10.7±1.6 to 2.9±1.8 μg/100 ml, free T4 from 1.77±0.4 to 0.94±0.35 ng/100 ml, total T3 from 0.99±0.23 to 0.35±0.2 ng/ml and TBG from 29.4±3.6 to 8.0±3.8 μg/ml. Basal TSH values tinuation of L-asparaginase, but following further treatment with other antileukemic agents, all values became normal within 2–4 weeks. In 6 patients with hypothyroid free T4 values TRH induced TSH release was totally blocked during L-asparaginase therapy. Our data clearly demonstrated that L-asparaginase caused a transient TBG deficiency. Total T4 and T3 were in the hypothyroid range because of low TBG concentrations. In addition to TBG deficiency transient, secondary hypothyroidism occurred in approximately 40–50% of all patients treated with L-asparaginase. These alterations were most likely caused by drug induced inhibition of protein synthesis. Under certain circumstances thyroid hormone replacement might be life-saving in severely ill patients suffering from transient, drug induced hypothyroidism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442997
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  • 8
    Electronic Resource
    Electronic Resource
    Pulsatile secretion of luteinizing hormone and sleep-related gonadotropin rhythms in girls with premature thelarche (1984)
    Springer
    European journal of pediatrics 141 (1984), S. 168-170 
    Details
    ISSN: 1432-1076
    Keywords: Premature thelarche ; Sleep-dependent gonadotropin rhythms ; Pulsatile LH secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The concentrations of LH, FSH and PRL were determined in serum samples obtained at night in 1–2 h intervals as well as at 15 min intervals during a 3 h period between 9 and 12 p.m. and 9 and 12 a.m. in three girls with premature thelarche, who had not developed further signs of precocious puberty for more than 18 months. A sleep-dependent LH and FSH increase was documented in all of them with a predominance of FSH secretion during sleep and after LHRH stimulation. In all three girls an episodic pattern of LH was found during sleep. In daytime minor fluctuations of LH secretion were found in two patients whereas in one patient an episodic LH pattern was demonstrable with minor peak values as during sleep. Normal PRL secretion during sleep as well as after TRH stimulation excludes a permissive role of this hormone in premature thelarche. We conclude that in girls with isolated premature thelarche a matured hypothalamo-pituitary gonadotropin axis is active comparable to normal pubertal children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443217
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  • 9
    Electronic Resource
    Electronic Resource
    Endocrine studies in Blackfan-diamond anemia: Evidence for hypothalamic-pituitary dysfunction under frequent transfusion therapy (1980)
    Springer
    European journal of pediatrics 135 (1980), S. 103-105 
    Details
    ISSN: 1432-1076
    Keywords: Thalassemia ; Blackfan-Diamond anemia ; Hypothalamic dysfunction ; Hyperprolactinemia ; Hypogonadotropic hypogonadism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 13 year old boy with Blackfan-Diamond anemia treated with frequent transfusions was investigated for endocrine abnormalities. Prepubertal plasma LH and FSH values, lack of sleep-related hormone rhythms of the gonadotropins, as well as prepubertal responses of LH and FSH to acute stimulation with LHRH strongly suggests that a hypothalamic-pituitary abnormality is the cause of the hypogonadotropic hypogonadism observed in this patient. As a result of impaired stimulation of the gonads plasma testosterone was prepubertal. A three-to fourfold increase of basal plasma PRL values was found without any signs of a typical sleep-dependent increase. Values obtained ranged between 21 ng/ml and 24 ng/ml (normal range 5–8 ng/ml). A normal response to TRH stimulation was found. These results suggest that hemosiderosis may responsible for the hyperprolactinemia as a result of hypothalamic-pituitary dysfunction. Furthermore, dysfunction is demonstrated by prepubertal responses of LH and FSH to LHRH stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445904
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  • 10
    Electronic Resource
    Electronic Resource
    Normoprolactinemia in boys with marked gynecomastia (1981)
    Springer
    European journal of pediatrics 137 (1981), S. 41-44 
    Details
    ISSN: 1432-1076
    Keywords: Gynecomastia ; Prolactin ; Gonadotropins ; Steroids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pubertal gynecomastia normally occurs as a transient phenomenon of several months duration, whereas marked pubertal gynecomastia (more than 6 cm in diameter) may persist into aduldhood. In the present study the possible involvement of prolactin (PRL) secretion in the development of marked pubertal gynecomastia was investigated. The diurnal variations of PRL, luteinizing hormone (LH), follicle-stimulating hormone (FSH), as well as the basal values of testosterone (T) and estradiol (E2) were determined in 5 pubertal boys with marked gynecomastia and in 5 age-matched controls. Mean age of all patients was 14.4 years. The pubertal development was classified as P 3–4. In comparison to controls, boys with marked gynecomastia revealed no differences in basal values of PRL, LH and FSH, as well as in peak values of all hormones during sleep. The response of PRL, LH and FSH to LHRH/TRH stimulation was normal for pubertal age in both groups. In comparison to controls, decreased mean plasma T levels (P〈0.05) and slightly increased E2 levels (P〈0.05) were found in boys with marked gynecomastia. The E2/T ratio was also higher in boys with gynecomastia (P〈0.005). These data suggest that prolactin, a hormone which may be increased in galactorrhea, is not involved in the development of marked pubertal gynecomastia in boys. The above findings suggest that slightly elevated day-time E2 levels may be involved in the development of female-appearing breasts in pubertal boys.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441168
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