ISSN:
1432-1076
Keywords:
Thalassemia
;
Blackfan-Diamond anemia
;
Hypothalamic dysfunction
;
Hyperprolactinemia
;
Hypogonadotropic hypogonadism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 13 year old boy with Blackfan-Diamond anemia treated with frequent transfusions was investigated for endocrine abnormalities. Prepubertal plasma LH and FSH values, lack of sleep-related hormone rhythms of the gonadotropins, as well as prepubertal responses of LH and FSH to acute stimulation with LHRH strongly suggests that a hypothalamic-pituitary abnormality is the cause of the hypogonadotropic hypogonadism observed in this patient. As a result of impaired stimulation of the gonads plasma testosterone was prepubertal. A three-to fourfold increase of basal plasma PRL values was found without any signs of a typical sleep-dependent increase. Values obtained ranged between 21 ng/ml and 24 ng/ml (normal range 5–8 ng/ml). A normal response to TRH stimulation was found. These results suggest that hemosiderosis may responsible for the hyperprolactinemia as a result of hypothalamic-pituitary dysfunction. Furthermore, dysfunction is demonstrated by prepubertal responses of LH and FSH to LHRH stimulation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00445904
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