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  • 1
    Electronic Resource
    Electronic Resource
    LF 08–0299 In the prophylaxis and treatment of chronic rejection in a rat aortic allograft model (2000)
    Springer
    Transplant international 13 (2000), S. S565 
    Details
    ISSN: 1432-2277
    Keywords: Key words LF 08 ; 299 ; Chronic rejection ; Immunosuppression aortic allograft model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic rejection is the major cause of late kidney allograft failure. We evaluated the efficacy of LF 08–299 (LF), an analogue of 15-deoxyspergualin, in a rat aortic allograft model of chronic rejection. BN aortic allografts were transplanted to Lew recipients. LF was administered at a dose of 6 mg/kg and 2.5 mg/kg on days 0–20 and 6 mg/kg on days 60–90. CyA was used at a dose of 5 mg/kg on days 0–20. Untreated isografts and allografts were used as controls. Histological changes and immunohistochemistry were monitored sequentially at 8, 12, 16 and 20 weeks. There were no differences in intimal proliferation between LF-treated allografts and untreated or CyA-treated controls. Only a tendency in adventitial infiltration reduction was seen in LF-treated animals. We found a significantly less pronounced reduction in media diameter in LF-treated animals. We concluded that LF 08–0299 is only able to reverse reduction in media thickness in aortic allografts, but not intimal proliferation in this model of chronic rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050404
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  • 2
    Electronic Resource
    Electronic Resource
    Arteriolosclerosis of the human renal allograft: morphology, origin, life history and relationship to cyclosporine therapy (1991)
    Springer
    Virchows Archiv 418 (1991), S. 129-141 
    Details
    ISSN: 1432-2307
    Keywords: Kidney allotransplantation ; Renal biopsy ; Cyclosporin A toxicity ; Graft arteriolosclerosis ; Renal ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the decade 1979–1988, 658 biopsies were collected from 568 cadaveric renal allografts. In 118 grafts a non-proliferative insudative vasculopathy (IVA) was found in afferent vessels. Immunosuppression was based on azathioprine (AZA) or on cyclosporin A (CsA), from 1983. The prevalence and extent of IVA has increased significantly since 1984. Light microscopy showed fibrinoid and hyaline masses of varying extent; transmural insudative “knobs”, intimal oedema with metachromasia, and microthrombosis were also seen with CsA. The ultrastructure of the insudates was unremarkable but CsA grafts displayed early oedema and hypergranulation of endothelial cells with a disarray of smooth muscle cell (SMC) microfibrils, and pronounced degenerative changes of SMC. Rebiopsy showed stationary IVA in AZA grafts and progression in one-half of CsA-treated patients. Nephrectomy specimens revealed, however, a marked predominance of late rejection endarteritis; in only 3 cases was IVA and/or microthrombosis the possible cause of nephrectomy. The mean donor age was higher in severe IVA in CsA grafts and the mean post-transplantation interval at the time of diagnosis of IVA was significantly shorter in CsA-treated patients. No important differences in cumulative graft survival were seen between grafts with absent, moderate or severe IVA. Unused cadaveric donors' kidneys of comparable age exhibited normal arterioles or a slight focal insudative or hyaline lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600288
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  • 3
    Electronic Resource
    Electronic Resource
    Extramembranous deposits and “membranous” glomerulonephritis (1972)
    Springer
    Virchows Archiv 356 (1972), S. 293-306 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 15 renal puncture biopsies from 14 patients, electron microscopy revealed extramembranous deposits (EMD) in various developmental stages (or their residues) in glomerular capillaries. Florid EMD exhibited a regular granular substructure as well as a typical localization within the subpodocytal space. Ultrastructurally, a gradual regression of EMD and their incorporation into the basement membrane could be observed. Early florid EMD were found in acute glomerulonephritis or in the nephrotic syndrome persisting for several months, with only discrete to absent “membranous” changes with light microscopy. Late stages of EMD with predominantly degenerative changes of glomerular basement membranes and apparent “membranous” thickening in light microscopy, on the other hand, were characteristic of the nephrotic syndrome lasting for several years. At early stages of EMD, long-lasting remission up to clinical healing were observed in a half of the cases studied, whereas at a late “membranous” stage long-lasting remission took place only once in six cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548964
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of the third component of pig complement and its utilization in a C3b receptor study (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 975-977 
    Details
    ISSN: 1420-9071
    Keywords: Complement ; pig ; complement ; system ; C3b receptor ; β-globulin ; macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The third component of the pig complement system (C3) was isolated in hemolytically active form and characterized. The C3 component is a β-globulin with the molecular weight of 191,000 and is composed of 2 non-identical polypeptide chains of Mt 112,000 and 74,000. The isolated C3 can be used for the detection of the C3b receptor on the membranes of heterologous peritoneal macrophages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946467
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  • 5
    Electronic Resource
    Electronic Resource
    Experimental immune complex glomerulopathy: Immunomorphological aspects and correlations with human disease (1975)
    Springer
    International urology and nephrology 7 (1975), S. 219-233 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirteen rabbits received parenteral injections of human serum albumin (HSA) in regular doses and intervals during 6–32 weeks. The antigen load elicited immune responses of variable degree, giving a good correlation with the extent and quality of immune complex (IMC) deposition, as shown by immunological methods, electron and fluorescence microscopy and by histoautoradiography. Morphology of immune deposits (IMD) depended on the composition of the IMC and produced a continuous scale of glomerular involvement, ranging from minimal and focal to massive and diffuse deposition. Probable rudimentary traces of IMD were apparent in the ultrastructure even in animals with negative results of both immunological and immunfluorescence examinations. The relationships are discussed between experimental IMC-induced glomerulopathy on the one hand, and some problems of development and bioptic evaluation of human glomerulonephritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02082678
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  • 6
    Electronic Resource
    Electronic Resource
    Clinical detection of rejection nephropathy using125I-labelled fibrinogen (1976)
    Springer
    International urology and nephrology 8 (1976), S. 71-77 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using a modified fibrinogen-uptake (FUT) test, 22 patients were investigated at various intervals after kidney transplantation. Eight of the patients had developed or showed early clinical signs of acute rejection crisis at the time of measurement. Another fourteen patients formed the control group with no evidence of florid rejection process. Comparison of the125I-fibrinogen accumulation in the renal grafts between the two mentioned groups showed clear differences with high statistical significance (p〈0.001). Uptake of labelled fibrinogen was increased in every acute rejection transplant. Histologically the kidneys with increased accumulation of fibrinogen showed extensive deposits of fibrin in blood vessels, glomeruli, intracapillary thrombi and in the interstitium. Except for the limitations discussed in this paper we consider this test to be of a great clinical value in the diagnosis of rejection episodes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02081994
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  • 7
    Electronic Resource
    Electronic Resource
    Wegener's granulomatosis with bilateral necrotizing scleritis, polyarthritis and renal failure efficiently treated with immunosuppressive therapy (1986)
    Springer
    Clinical rheumatology 5 (1986), S. 112-117 
    Details
    ISSN: 1434-9949
    Keywords: Wegener's Granulomatosis ; Necrotizing Scleritis ; Polyarthritis ; Focal Necrotizing Glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case report of a female patient with Wegener's granulomatosis is presented. After an initial involvement of the upper respiratory tract in the form of a sinusitis, there followed a severe necrotizing bilateral scleritis necessitating the enucleation of the left eye ball. Renal involvement developed as late as 24 months after the onset of the disease and led to renal failure within three months. Throughout the duration of her disease, the patient had joint symptoms in the form of episodes of migratory nondeforming polyarthritis. The administration of corticosteroids alone in daily doses up to 60 mg prednisone failed to control the progression of the disease, while immunosuppressive therapy with cyclophosphamide combined with methylprednisolone pulse therapy and haemodialysis resulted in a marked improvement of renal function and in the subsidence of the ocular and articular symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030979
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  • 8
    Electronic Resource
    Electronic Resource
    Influence of preexistent pyelonephritis on the development and manifestations of acute fatal glomerulonephritis (1973)
    Springer
    International urology and nephrology 5 (1973), S. 107-115 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a 39-year-old woman suffering for five years from chronic pyelonephritis with a stationary course, a sudden lethal renal failure occurred after an intercurrent febrile respiratory disease. The autopsy revealed scarred pyelonephritic kidneys with swollen hypertrophic areas. Microscopically, in sclerotic segments the glomeruli either were preserved or exhibited only various stages of vascular atrophy. Outside the pyelonephritic areas, however, massive subacute extra-intracapillary glomerulonephritis with typical “crescents” was apparent. — The role played by preexistent renal lesion in the pathogenesis of glomerulonephritis, and some problems involved in the diagnosis of coexistent glomerulo- and pyelonephritis, are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02081756
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