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  • 1
    Online Resource
    Online Resource
    Reference Ranges of Lymphocyte Subsets of Healthy Adults in Turkey
    S. Karger AG ; 2005
    In:  Medical Principles and Practice Vol. 14, No. 3 ( 2005), p. 189-193
    Details
    In: Medical Principles and Practice, S. Karger AG, Vol. 14, No. 3 ( 2005), p. 189-193
    Abstract: 〈 i 〉 Abstract: 〈 /i 〉 The aim of this study was to determine the reference ranges of lymphocyte subsets in serologically HIV-negative healthy adults in Turkey. 〈 i 〉 Materials and Methods: 〈 /i 〉 Blood samples from 220 healthy adults, 105 female and 115 male, collected into tubes containing EDTA were investigated for lymphocyte subsets using flow cytometry. The age range was 18–80 years (44.80 ± 16.69). 〈 i 〉 Results: 〈 /i 〉 The mean percentage and absolute values of the lymphocyte subsets were as follows: CD3: 72.70 ± 8.44%, 1,680 ± 528 cells/µl; CD4: 47.37 ± 9.10%, 1,095 ± 391 cells/µl; CD8: 28.99 ± 5.99%, 669 ± 239 cells/µl; CD19: 10.96 ± 4.44%, 254 ± 122 cells/µl and CD56: 7.03 ± 3.26%, 161 ± 92 cells/µl, respectively. The ratio of CD4/CD8 was 1.68 ± 0.43. There was no statistically significant difference in the percentages and absolute value 〈 i 〉 s 〈 /i 〉 of lymphocyte subsets between the genders (p 〉 0.05). 〈 i 〉 Conclusion: 〈 /i 〉 Immunophenotyping has been used to establish reference values of lymphocyte subsets in normal healthy adults in Turkey.
    Type of Medium: Online Resource
    ISSN: 1011-7571 , 1423-0151
    URL: Article
    DOI: 10.1159/000084638
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482963-0
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  • 2
    Online Resource
    Online Resource
    CA9 Expression as a Prognostic Factor in Renal Clear Cell Carcinoma
    S. Karger AG ; 2005
    In:  Urologia Internationalis Vol. 74, No. 1 ( 2005), p. 68-73
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 74, No. 1 ( 2005), p. 68-73
    Abstract: 〈 i 〉 Introduction: 〈 /i 〉 We investigated whether CA9 protein could be used as a prognostic tumor marker as well as a diagnostic biomarker in renal clear cell carcinoma. 〈 i 〉 Materials and Methods: 〈 /i 〉 Nephrectomy specimens from 92 patients were used in this study. 80 of these were renal cell carcinomas, 10 adenomas and 2 oncocytomas. Of the renal cell carcinomas, 67 were clear cell carcinomas. Immunohistochemical analysis using CA9 monoclonal antibody (M75) was performed on paraffin-embedded specimens. CA9 staining was correlated with tumor stage, grade, lymph node involvement, distant metastasis and cumulative survival time. 〈 i 〉 Results: 〈 /i 〉 CA9 was present in 91.2% of clear cell carcinomas. Low staining was a poor prognostic factor, and conversely high staining a good prognostic one. CA9 expression was found to be the best prognostic factor when compared with T stage and grade. Even in low-grade and stage tumors, the presence of low expression correlated with lowered survival times. 〈 i 〉 Conclusions: 〈 /i 〉 On the basis of our study, CA9 is a significant molecular marker in renal clear cell carcinomas. Decreased CA9 expression is independently associated with poor survival. CA9 can be used to predict clinical outcome and identify high-risk patients in need for adjuvant immunotherapy and CA9 targeted therapies.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000082713
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1464417-4
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  • 3
    Online Resource
    Online Resource
    Comparison of Blood Gas and Acid-Base Measurements in Arterial and Venous Blood Samples in Patients with Uremic Acidosis and Diabetic Ketoacidosis in the Emergency Room
    S. Karger AG ; 2000
    In:  American Journal of Nephrology Vol. 20, No. 4 ( 2000), p. 319-323
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 20, No. 4 ( 2000), p. 319-323
    Abstract: 〈 i 〉 Background/aims: 〈 /i 〉 The aim of this study was to examine a plausible correlation between venous and arterial blood gas values in acidotic patients with chronic uremia or diabetic ketoacidosis (DKA). 〈 i 〉 Methods: 〈 /i 〉 A total of 152 arterial and 152 venous blood samples from uremic patients (n = 100), DKA patients (n = 21) and healthy controls (n = 31) were analyzed for measurements of blood gas and acid-base status. 〈 i 〉 Results: 〈 /i 〉 The means of arterial and venous pH, and arterial and venous HCO 〈 sup 〉 – 〈 /sup 〉 〈 sub 〉 3 〈 /sub 〉 values for the uremic patients were 7.17 ± 0.14, 7.13 ± 0.14, 10.13 ± 4.26 and 11.86 ± 4.23 mmol/l, respectively. The respective mean differences between arterial and venous pH values and arterial and venous HCO 〈 sup 〉 – 〈 /sup 〉 〈 sub 〉 3 〈 /sub 〉 values were 0.04 ± 0.02 and –1.72 ± 0.42 mmol/l, respectively, for these patients. The means of the laboratory findings of DKA patients were arterial pH, 7.15 ± 0.15; venous pH, 7.10 ± 0.15; arterial HCO 〈 sup 〉 – 〈 /sup 〉 〈 sub 〉 3 〈 /sub 〉 , 8.57 ± 5.71 mmol/l and venous HCO 〈 sup 〉 – 〈 /sup 〉 〈 sub 〉 3 〈 /sub 〉 , 10.46 ± 5.73 mmol/l. The respective mean differences between arterial and venous pH and arterial and venous HCO 〈 sup 〉 – 〈 /sup 〉 〈 sub 〉 3 〈 /sub 〉 for this group were calculated to be 0.05 ± 0.01 and –1.88 ± 0.41 mmol/l. In the healthy controls, the means of arterial and venous pH, and arterial and venous HCO 〈 sup 〉 – 〈 /sup 〉 〈 sub 〉 3 〈 /sub 〉 values were 7.39 ± 0.02, 7.34 ± 0.02, 24.91 ± 0.82 and 26.57 ± 0.83 mmol/l, respectively. For the healthy controls the mean differences between the respective values in arterial and venous pH, and arterial and venous HCO 〈 sup 〉 – 〈 /sup 〉 〈 sub 〉 3 〈 /sub 〉 were 0.05 ± 0.01 and –1.66 ± 0.58 mmol/l. Although in healthy controls the correlation between arterial and venous pH values (r 〈 sup 〉 2 〈 /sup 〉 : 0.595) and arterial and venous HCO 〈 sup 〉 – 〈 /sup 〉 〈 sub 〉 3 〈 /sub 〉 values (r 〈 sup 〉 2 〈 /sup 〉 : 0.552) were moderate, these correlations were significantly increased in both the acidotic patient group (r 〈 sup 〉 2 〈 /sup 〉 : 0.979 and 0.990) and the DKA group (r 〈 sup 〉 2 〈 /sup 〉 : 0.989 and 0.995) 〈 i 〉 Conclusion: 〈 /i 〉 A venous blood sample can be used to evaluate the acid-base status in uremic and DKA patients.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000013607
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2000
    detail.hit.zdb_id: 1468523-1
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  • 4
    Online Resource
    Online Resource
    The Trend of Change of Allergic Diseases over the Years: Three Repeated Surveys from 1994 to 2014
    S. Karger AG ; 2017
    In:  International Archives of Allergy and Immunology Vol. 173, No. 3 ( 2017), p. 178-182
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 173, No. 3 ( 2017), p. 178-182
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Although it is known that there has been an increase in asthma and allergic diseases among school-aged children, results vary between countries. The aim of this study was to examine trends in the prevalence of these diseases in the city of Adana (south Turkey) over the last 20 years based on the results of 3 cross-sectional studies. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Three cross-sectional surveys were performed 10 years apart in south Turkey. Here, we compare the surveys conducted among children between the ages of 6 and 14 years from 1994, 2004, and 2014. The participants were randomly chosen among children attending participating primary schools in Adana. The questionnaire in the first survey contained almost the same questions as the ISAAC. In the 2 latter surveys, we used the ISAAC questionnaire to investigate the prevalence of asthma and other allergic diseases. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 2,334 children in 1994, 3,728 children in 2004, and 3,209 children in 2014 were included in the final analysis. The results showed a statistically significant increase in the prevalence of physician-diagnosed allergic diseases across the years, respectively: asthma (5, 4.6, and 8.9%), allergic rhinitis (8.8, 11.4, and 15.6%), and atopic dermatitis (5, 9.9, and 7%). In contrast, the prevalence of parent-reported current wheeze (16.2, 13.2%) decreased in the last 10 years. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our findings were consistent with the increased prevalence of childhood asthma and other allergic diseases. However, this pattern did not occur in respiratory symptoms.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000477726
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1482722-0
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