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  • Springer  (3)
  • Nature Publishing Group  (1)
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  • 1
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The hominoid partial skull and several postcranial elements (to be described elsewhere) were discovered at locality 12 (40° 15' 02" N, 32° 38' 58" E) on the southernmost hilltop of Deli-kaymcak Tepe, a prominent ridge located about 2.5 km north of the village of Yassioren. Fossils have been ...
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  • 2
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pneumopericardium occurred in 28 neonates with respiratory distress syndrome at the University of Minnesota Hospitals and St. Paul Children's Hospital from July 1, 1972 through June 30, 1976. All patients developed this complication while on mechanical ventilatory support with positive end-expiratory pressure (2–12 cm water). In 23 patients, pneumopericardium resulted in clinical pericardial tamponade that necessitated cardiac resuscitation. The clinical presentation of pericardial tamponade consisted of muffled, distant heart sounds, hypotension, bradycardia, and hypoxia with cyanosis. The diagnosis was confirmed by chest x-ray. Pneumothorax, pneumomediastinum, and/or pneumoperitoneum were associated with the appearance of pneumopericardium in 93% of the cases. Treatment consisted of: (a) needle pericardial aspiration in 7 patients, of which 5 survived; (b) pericardial tube placement with application of suction in 10 patients, of which 8 survived; (c) no treatment in 16 patients, of which 5 survived. Overall, 13 patients (46%) survived pneumopericardium and 15 patients (54%) died. Complications of treatment developed in 5 patients; 3 developed pneumothorax and 2 developed myocardial lacerations from percutaneous placement of a plastic drainage catheter. Of 5 asymptomatic patients, 2 (40%) died as a result of pneumopericardium. Based on our experience, it is recommended that pneumopericardium be evacuated whenever it is diagnosed. Initially, needle aspiration of the pericardial sac should be performed to manage the acute episode and stabilize the patient, and then a chest catheter of No. 10 Fr. caliber should be placed under direct vision into the pericardial sac and maintained on suction until positive end-expiratory pressure ventilation has been discontinued.
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  • 3
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Entre 1972 et 1976, 140 malades ont subi un remplacement de valve aortique avec une prothèse de Lillehei-Kaster (LK) et 18 autres un remplacement valvulaire aortique combiné à un bypass coronaire: 98% des cas ont été suivis. La mortalité postopératoire est de 7.5%. La survie actuarielle à 5 ans est de 79%. Il y a eu 2 épisodes de thrombo-embolie sur 3,645 mois/malades. Il n'y a eu ni malfonction de la prothèse, ni hémolyse significative. Le cathétérisme postopératoire montre une surface fonctionnelle de la valve de 0.81 cm2 pour les prothèses 14A et de 1.1 cm2 pour les autres valves. Nous recommandons l'emploi de valves aortiques LK de tailles supérieures à 14A avec anticoagulation par warfarine.
    Notes: Abstract From 1972 through 1976, 140 patients underwent aortic valve replacement (AVR) with the Lillehei-Kaster (LK) prosthesis and 18 additional patients had AVR plus coronary bypass procedures. Follow- up information was obtained in 98% of the patients. The operative mortality rate was 7.5% and the actuarial 5- year survival rate was, 79%. Two episodes of thromboembolism occurred in 3,645 patient-months. Prosthesis malfunction or significant hemolysis has not occurred. Postoperative catheterization studies revealed a functional valve area of 0.81 cm2 with the 14A prosthesis; all other valve areas were greater than 1.1 cm2. Continued use of the LK aortic valve prosthesis with warfarin anticoagulation is recommended in sizes greater than 14A.
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  • 4
    ISSN: 1573-5028
    Keywords: copper detoxification ; metallothionein ; metal tolerance ; pea ; Pisum sativum ; PsMT A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The PsMT A gene from pea (Pisum sativum) shares similarity with metallothionein (MT) genes and related sequences have also been isolated from a number of other higher-plant species. The proteins encoded by these genes have not yet been purified from plants and their functions remain unclear although, by analogy to MT, roles in the metabolism and detoxification of metal ions have been proposed. By contrast, correlation between transcript abundance and Fe availability has led to an alternative proposal that these genes are involved in mechanisms of Fe efficiency. Phenotypic effects of constitutive PsMT A expression were examined in Escherichia coli and Arabidopsis thaliana. Copper accumulation by E. coli cells expressing recombinant PsMTA protein was approximately 8-fold greater than in control cells. No significant effects on the accumulation of Zn or Cd were detected. In segregating A. thaliana progeny, derived from a transgenic F1 parent containing the PsMT A gene under the control of a CaMV 35S promoter, 75% of individuals accumulated more Cu (several-fold in some plants) than untransformed, control plants. These data suggest that PsMTA protein binds Cu in planta and that uncoupled (constitutive) expression of the PsMT A gene causes enhanced Cu accumulation. Roots of P. sativum plants grown under conditions of low Fe availability showed elevated activity of root surface Fe(III) reductase and accumulated more Cu than roots of plants grown in an Fe-supplemented solution. Changes in the expression of MT-like genes, coincident with changes in Fe availability, are consistent with a role in Cu homoeostasis.
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