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  • 1
    Book
    Book
    Estuarine chemistry : [based upon lectures given at a meeting, London, 16.5.1974] (1976)
    London [u.a.] : Acad. Pr.
    Details Availability
    Keywords: Estuaries ; Water quality ; Rivers ; Konferenzschrift ; Mündung ; Chemischer Prozess
    Type of Medium: Book
    Pages: XII, 229 S , graph. Darst
    ISBN: 0121473503
    DDC: 551.46/09
    RVK:
    WI 4620
    RVK:
    RB 10295
    Language: English
    Note: Based on lectures given at a meeting of the Estuarian a nd Brackish-Water Sciences Association and the Marine Chem istry Discussion Group held in London, 1974 Includes bibliographical references and index. London, 1974 Includes bibliographical references and index
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  • 2
    Electronic Resource
    Electronic Resource
    Oscillations in oxygen tension and insulin release of individual pancreatic ob/ob mouse islets (2000)
    Springer
    Diabetologia 43 (2000), S. 1313-1318 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Oscillation, metabolism, oxygen tension, insulin release, islet, glucose, tolbutamide, heterogeneity, Clark electrode, ELISA.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. The role of beta-cell metabolism for generation of oscillatory insulin release was investigated by simultaneous measurements of oxygen tension (pO2) and insulin release from individual islets of Langerhans.¶Methods. Individual islets isolated from the ob/ob-mice were perifused. Insulin in the perifusate was measured with a sensitive ELISA and pO2 with a modified Clark-type electrode inserted into the islets.¶Results. In the presence of 3 mmol/l d-glucose, pO2 was 102 ± 9 mmHg and oscillatory (0.26 ± 0.04 oscillations/min). Corresponding insulin measurements showed oscillatory release with similar periodicity (0.25 ± 0.02 oscillations/min). When the d-glucose concentration was increased to 11 mmol/l, pO2 decreased by 30 % to 72 ± 10 mmHg with maintained frequency of the oscillations. Corresponding insulin secretory rate rose from 5 ± 2 to 131 ± 16 pmol · g–1· s–1 leaving the frequency of the insulin pulses unaffected. The magnitude of glucose-induced change in pO2 varied between islets but was positively correlated to the amount of insulin released (r 2 = 0.85). When 1 mmol/l tolbutamide was added to the perifusion medium containing 11 mmol/l glucose no change in average oscillatory pO2 was observed despite a doubling in the secretory rate. When 8 mmol/l 3-oxymethyl glucose was added to perifusion medium containing 3 mmol/l d-glucose, neither pO2 nor insulin release of the islets were changed. Temporal analysis of oscillations in pO2 and insulin release revealed that maximum respiration correlated to maximum or close to maximum insulin release.¶Conclusion/interpretation. The temporal relation between oscillations in pO2 and insulin release supports a role for metabolic oscillations in the generation of pulsatile insulin release. [Diabetologia (2000) 43: 1313–1318]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051528
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  • 3
    Electronic Resource
    Electronic Resource
    Intrarenal oxygen tension measured by a modified Clark electrode at normal and low blood pressure and after injection of x-ray contrast media (1997)
    Springer
    Pflügers Archiv 434 (1997), S. 705-711 
    Details
    ISSN: 1432-2013
    Keywords: Key words Renal medulla ; Microelectrode ; Acute renal failure ; Hypotension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The oxygen tension (pO2) in the rat kidney was studied using a Clark microelectrode with a guard cathode behind the sensing cathode. The mean (± SEM) outer tip diameter of the electrodes used was 5.5 ± 1.9 μm. The zero-pO2 current amounted to 12.5 ± 0.9 pA at 37°C; at air saturation it was 252 ± 22.9 pA. Rats with a systolic blood pressure (BP) above 80 mmHg (where 1 mmHg = 133 Pa) showed an average pO2 in the cortex of 45 ± 2 mmHg and in the outer medulla of 31 ±1 mmHg. In rats with a BP below 80 mmHg a paradoxically high outer medullary pO2 of 40 ± 4 mmHg was found, while the pO2 in the cortex was 27 ± 4 mmHg. Changes in pO2 were also noted in the renal cortex and outer medulla after intravenous injections of the x-ray contrast medium diatrizoate (370 mg iodine/ml). In rats with normal BP, injection of diatrizoate caused a slight fall in pO2 in the renal cortex, from 42 ± 4 to 38 ±4 mmHg. In the medulla pO2 decreased significantly from 34 ± 6 to 20 ±4 mmHg. Ringer’s solution did not induce any changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050455
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  • 4
    Electronic Resource
    Electronic Resource
    Bone substitutes (1999)
    Springer
    European journal of orthopaedic surgery & traumatology 9 (1999), S. 161-165 
    Details
    ISSN: 1432-1068
    Keywords: Bone ; Bone substitutes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Biocompatible calcium phosphate ceramics has been used for several years in orthopeadic surgery. We have been using two new synthetic biphasic calcium phosphate ceramics (BCP) since September 1996 for bone defect filling in any orthopaedic or trauma operation where autograft use was not possible or even wanted. The first, Eurocer 400® has 300 to 500 micron wide macropores with a totally interconnected porosity. This salt seed like product can be used in bone defect filling, when solidity is not a major concern. The second, Eurocer 200® has not totally interconnected 200 micron large pores. Its main characteristic is a mechanical resistance up to 30 Mpa. We use it in any case of weight-bearing surgery. Different sizes and presentation forms are available and will be chosen according to the recipient site shape. We report one hundred and fifty cases with a six to thirty month follow-up. In one third of the patients hip revision surgery was addressed. Another third concerned recent trauma or sequelae cases,.whereas the last third involved cold orthopaedic procedures. General principles are the need of a living and non-infected site after thorough debridement if necessary. Osteocompatibility of calcium phosphate ceramic is confirmed by our results. We report no mechanical failure. In all cases X-rays show a progressive integration, with new bone formation. Our substitutes have been histologically studied in nine cases, four to fifteen months after implantation. New bone formation around and in the substitute is impressive. Indeed, their good mechanical properties without loss of biological quality is the most relevant feature of these BCPs, leading to a wider indication field; therefore we have now abandoned the use of any bony auto, allo or xenograft.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542583
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  • 5
    Electronic Resource
    Electronic Resource
    Biphasic synthetic bone substitute use in orthopaedic and trauma surgery: clinical, radiological and histological results (1999)
    Springer
    Journal of materials science 10 (1999), S. 821-825 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Searching for an alternative to bone grafts in orthopedic and trauma surgery, two biphasic synthetic calcium phosphate ceramics BCP are made: the first, Eurocer 400®, in granule form with a high interconnected porosity for void-filling, and the second, Eurocer 200®, available in different shapes, with a good mechanical resistance in compression. Two hundred cases are reported with more than a six-month follow-up. The first 72 cases relating to hip arthroplasty revision surgery (29 involving acetabular and 43 femoral stem loosening) are exposed with some technical details. The next 71 cases concerning trauma and sequels are displayed with technical particulars. The remaining 57 other cold orthopedic indications are then enumerated. The very good biocompatibility of these ceramics is confirmed. Radiological incorporation is quickly seen in all the cases, faster with the filling substitute than with the second one, which, however, presents no mechanical failures when classical technical principles are respected. Finally, some histological studies are presented; the ceramics are progressively resorbed and bone reconstruction in and close to the substitutes is noticed. Therefore, the use of biophasic ceramics in almost all orthopedic and trauma surgery is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008944227417
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