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  • Articles  (26)
  • MDPI Publishing  (9)
  • Nature Publishing Group (NPG)  (8)
  • Wiley-Blackwell  (8)
  • Blackwell Science Ltd  (1)
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  • Articles  (26)
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  • 1
    Electronic Resource
    Electronic Resource
    Phosphorylation of HMG-I by Protein Kinase C Attenuates Its Binding Affinity to the Promoter Regions of Protein Kinase C γ and Neurogranin/RC3 Genes (2000)
    Oxford UK : Blackwell Science Ltd
    Journal of neurochemistry 74 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A 20-kDa DNA-binding protein that binds the AT-rich sequences within the promoters of the brain-specific protein kinase C (PKC) γ and neurogranin/RC3 genes has been characterized as chromosomal nonhistone high-mobility-group protein (HMG)-I. This protein is a substrate of PKC α, β, γ, and δ but is poorly phosphorylated by PKC ε and ζ. Two major (Ser44 and Ser64) and four minor phosphorylation sites have been identified. The extents of phosphorylation of Ser44 and Ser64 were 1:1, whereas those of the four minor sites all together were 〈30% of the major one. These PKC phosphorylation sites are distinct from those phosphorylated by cdc2 kinase, which phosphorylates Thr53 and Thr78. Phosphorylation of HMG-I by PKC resulted in a reduction of DNA-binding affinity by 28-fold as compared with 12-fold caused by the phosphorylation with cdc2 kinase. HMG-I could be additively phosphorylated by cdc2 kinase and PKC, and the resulting doubly phosphorylated protein exhibited a 〉 100-fold reduction in binding affinity. The two cdc2 kinase phosphorylation sites of HMG-I are adjacent to the N terminus of two of the three predicted DNA-binding domains. In comparison, one of the major PKC phosphorylation sites, Ser64, is adjacent to the C terminus of the second DNA-binding domain, whereas Ser44 is located within the spanning region between the first and second DNA-binding domains. The current results suggest that phosphorylation of the mammalian HMG-I by PKC alone or in combination with cdc2 kinase provides an effective mechanism for the regulation of HMG-I function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0740392.x
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    Paper (German National Licenses)
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  • 2
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    Small-molecule activation of the TRAIL receptor DR5 in human cancer cells (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-01-19
    Description: Nature Chemical Biology 9, 84 (2013). doi:10.1038/nchembio.1153 Authors: Gelin Wang, Xiaoming Wang, Hong Yu, Shuguang Wei, Noelle Williams, Daniel L Holmes, Randal Halfmann, Jacinth Naidoo, Lai Wang, Lin Li, She Chen, Patrick Harran, Xiaoguang Lei & Xiaodong Wang
    Print ISSN: 1552-4450
    Electronic ISSN: 1552-4469
    Topics: Biology , Chemistry and Pharmacology
    Published by Nature Publishing Group (NPG)
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  • 3
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    Estimating the vertical profiles of cloud water content in warm rain clouds (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-08-27
    Description: The cloud water content (CWC) in rainy clouds is a crucial parameter to determine the onset and the growth rate of precipitation, and to quantify the associated latent heating rate. No direct retrieval of CWC in rainy cloud from satellite observations is reported due to the difficulties of separating cloud particles from precipitation sized particles. However, based on multiple cloud simulations from the Weather and Research Forecasting (WRF) model, we have found that the CWC profile in warm rains can be well determined by three macro-physical cloud properties of cloud water path (CWP), cloud top height (CTH), and cloud bottom height (CBH). The CBH can be estimated using CWP, CTH and near surface rain rate. We proposed an algorithm with a lookup table for estimating the CWC profile using CWP, CTH and near surface rain rate as inputs. The performance of this algorithm was tested with WRF model simulations and a real drizzle case observed by the CloudSat satellite. Testing verified that the algorithm can retrieve the vertical distribution of CWC correctly with few errors at different spatiotemporal scales. In addition, the algorithm is not confined to particular microphysics schemes and is valid for multiple cloud systems in different areas over the world. This algorithm is expected to improve current knowledge of cloud water content in rainy clouds.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 4
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    An efficient process for wastewater treatment to mitigate free nitrous acid generation and its inhibition on biological phosphorus removal (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-02-28
    Description: Free nitrous acid (FNA), which is the protonated form of nitrite and inevitably produced during biological nitrogen removal, has been demonstrated to strongly inhibit the activity of polyphosphate accumulating organisms (PAOs). Herein we reported an efficient process for wastewater treatment, i.e., the oxic/anoxic/oxic/extended-idle process to mitigate the generation of FNA and its inhibition on PAOs. The results showed that this new process enriched more PAOs which thereby achieved higher phosphorus removal efficiency than the conventional four-step (i.e., anaerobic/oxic/anoxic/oxic) biological nutrient removal process (41 ± 7% versus 30 ± 5% in abundance of PAOs and 97 ± 0.73% versus 82 ± 1.2% in efficiency of phosphorus removal). It was found that this new process increased pH value but decreased nitrite accumulation, resulting in the decreased FNA generation. Further experiments showed that the new process could alleviate the inhibition of FNA on the metabolisms of PAOs even under the same FNA concentration. Scientific Reports 5 doi: 10.1038/srep08602
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 5
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    Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-04-11
    Description: Article Psoriasis is a chronic inflammatory disease affecting up to 3% of the population. Here, Zuo et al. perform exome array analysis, identify single-nucleotide polymorphisms at 15 new loci, implicating several biological pathways in psoriasis risk and disease heritability. Nature Communications doi: 10.1038/ncomms7793 Authors: Xianbo Zuo, Liangdan Sun, Xianyong Yin, Jinping Gao, Yujun Sheng, Jinhua Xu, Jianzhong Zhang, Chundi He, Ying Qiu, Guangdong Wen, Hongqing Tian, Xiaodong Zheng, Shengxiu Liu, Wenjun Wang, Weiran Li, Yuyan Cheng, Longdan Liu, Yan Chang, Zaixing Wang, Zenggang Li, Longnian Li, Jianping Wu, Ling Fang, Changbing Shen, Fusheng Zhou, Bo Liang, Gang Chen, Hui Li, Yong Cui, Aie Xu, Xueqin Yang, Fei Hao, Limin Xu, Xing Fan, Yuzhen Li, Rina Wu, Xiuli Wang, Xiaoming Liu, Min Zheng, Shunpeng Song, Bihua Ji, Hong Fang, Jianbin Yu, Yongxin Sun, Yan Hui, Furen Zhang, Rongya Yang, Sen Yang, Xuejun Zhang
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    IJGI, Vol. 7, Pages 85: Assessment of Multiple GNSS Real-Time SSR Products from Different Analysis Centers (2018)
    MDPI Publishing
    Details
    Publication Date: 2018-03-09
    Description: IJGI, Vol. 7, Pages 85: Assessment of Multiple GNSS Real-Time SSR Products from Different Analysis Centers ISPRS International Journal of Geo-Information doi: 10.3390/ijgi7030085 Authors: Zhiyu Wang Zishen Li Liang Wang Xiaoming Wang Hong Yuan The real-time State Space Representation (SSR) product of the GNSS (Global Navigation Satellite System) orbit and clock is one of the most essential corrections for real-time precise point positioning (PPP). In this work, the performance of current SSR products from eight analysis centers were assessed by comparing it with the final product and the accuracy of real-time PPP. Numerical results showed that (1) the accuracies of the GPS SSR product were better than 8 cm for the satellite orbit and 0.3 ns for the satellite clock; (2) the accuracies of the GLONASS (GLObalnaya NAvigatsionnaya Sputnikovaya Sistema) SSR product were better than 10 cm for orbit RMS (Root Mean Square) and 0.6 ns for clock STD (Standard Deviation); and (3) the accuracies of the BDS (BeiDou Navigation Satellite System) and Galileo SSR products from CLK93 were about 14.54 and 4.42 cm for the orbit RMS and 0.32 and 0.18 ns for the clock STD, respectively. The simulated kinematic PPP results obtained using the SSR products from CLK93 and CLK51 performed better than those using other SSR products; and the accuracy of PPP based on all products was better than 6 and 10 cm in the horizontal and vertical directions, respectively. The real-time kinematic PPP experiment carried out in Beijing, Tianjin, and Shijiazhuang, China indicated that the SSR product CLK93 from Centre National d’Etudes Spatiales (CNES) had a better performance than CAS01. Moreover, the PPP with GPS + BDS dual systems had a higher accuracy than those with only a GPS single system.
    Electronic ISSN: 2220-9964
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Published by MDPI Publishing on behalf of International Society for Photogrammetry and Remote Sensing (ISPRS).
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  • 7
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    Observed cold filaments associated with mesoscale eddies in the South China Sea (2017)
    Wiley-Blackwell
    Details
    Publication Date: 2017-01-11
    Description: Unusual cold filaments are uncovered during the spring intermonsoon season in the South China Sea (SCS) using a suite of satellite observations. They have a width of about 100 km on average and extend several hundreds of kilometers offshore on the sea surface, providing significant cross-shelf transport of heat and nutrients. The eastward current associated with mesoscale eddies in spring in the western SCS is found to play an important role in the filament formation by advecting coastal cold waters far offshore. The meridional location of the cold filament displays considerable interannual variability ranging between 9 o N and 18 o N, which can be attributed to the interannual south-north shift of the eastward current associated with eddies. It is also found that in the spring, cold filaments have profound effects on the chlorophyll a concentration in the upper ocean and the overlying atmosphere. These findings provide new insights into the role of eddies in cross-shelf exchange and mesoscale air-sea interaction in the marginal seas.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 8
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    Sensors, Vol. 17, Pages 201: A Lift-Off-Tolerant Magnetic Flux Leakage Testing Method for Drill Pipes at Wellhead (2017)
    MDPI Publishing
    In: Sensors
    Details
    Publication Date: 2017-01-22
    Description: To meet the great needs for MFL (magnetic flux leakage) inspection of drill pipes at wellheads, a lift-off-tolerant MFL testing method is proposed and investigated in this paper. Firstly, a Helmholtz coil magnetization method and the whole MFL testing scheme are proposed. Then, based on the magnetic field focusing effect of ferrite cores, a lift-off-tolerant MFL sensor is developed and tested. It shows high sensitivity at a lift-off distance of 5.0 mm. Further, the follow-up high repeatability MFL probing system is designed and manufactured, which was embedded with the developed sensors. It can track the swing movement of drill pipes and allow the pipe ends to pass smoothly. Finally, the developed system is employed in a drilling field for drill pipe inspection. Test results show that the proposed method can fulfill the requirements for drill pipe inspection at wellheads, which is of great importance in drill pipe safety.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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  • 9
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    Energies, Vol. 11, Pages 1242: Optimal Scheduling Strategies of Distributed Energy Storage Aggregator in Energy and Reserve Markets Considering Wind Power Uncertainties (2018)
    MDPI Publishing
    In: Energies
    Details
    Publication Date: 2018-05-15
    Description: Energies, Vol. 11, Pages 1242: Optimal Scheduling Strategies of Distributed Energy Storage Aggregator in Energy and Reserve Markets Considering Wind Power Uncertainties Energies doi: 10.3390/en11051242 Authors: Zengqiang Mi Yulong Jia Junjie Wang Xiaoming Zheng With continuous technological improvement and economic development of energy storage, distributed energy storage (DES) will be widely connected to the distribution network. If fragmented DES systems are aggregated to form a distributed energy storage aggregator (DESA), the DESA will have great potential to participate in the day-ahead energy and reserve market and the balancing market. The DESA could act as a mediator between the market and DES consumers, enabling beneficial coordination for DES owners and power systems. This paper presents a bilevel optimization model for DESAs in the energy and reserve market under wind power uncertainties. In the lower-level problem, generating companies, wind power plants (WPP), and DESAs are optimized for scheduling day-ahead (DA) energy and the reserve market. In the upper-level problem, operational strategies for DES systems and DESAs are designed to deal with wind power uncertainties in the balancing market. The DESA splits its resources between the energy and reserve markets so that it can reduce total power system consumption, and mutual profit for the system and end customers is achieved. This model is formulated as a mixed-integer linear programming (MILP) program, which can be solved with commercial software. The validity of the bilevel optimization model is verified by the eight-node test transmission system and IEEE-33 bus distribution system.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 10
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    Sustainability, Vol. 10, Pages 1372: Measuring the Direct and Indirect Effects of Neighborhood-Built Environments on Travel-related CO2 Emissions: A Structural Equation Modeling Approach (2018)
    MDPI Publishing
    Details
    Publication Date: 2018-04-29
    Description: Sustainability, Vol. 10, Pages 1372: Measuring the Direct and Indirect Effects of Neighborhood-Built Environments on Travel-related CO2 Emissions: A Structural Equation Modeling Approach Sustainability doi: 10.3390/su10051372 Authors: Wenyue Yang Shaojian Wang Xiaoming Zhao Intervening in the built environment is a key way for land-use and transport planning and related policies to promote low-carbon development and low-carbon travel. It is of significance to explore and recognize the actual impact of the neighborhood built environment on travel-related CO2 emissions. This study calculated the CO2 emissions from four purposes of trips, which were within the urban region, using Travel O-D Point Intelligent Query System (TIQS) and 1239 residents’ travel survey questionnaires from 15 neighborhoods in Guangzhou. It measured the direct and indirect effects of built environments on CO2 emissions from different purposes of trips by developing structural equation models (SEMs). The results showed that for different purposes of trips, the effects of the neighborhood built environments on CO2 emissions were inconsistent. Almost all built environment elements had significant total effects on CO2 emissions, which were mainly indirect effects through mediators such as car ownership and trip distance, then affecting CO2 emissions indirectly. Most of the direct effects of neighborhood built environments on CO2 emissions were not significant, especially those from non-commuting trips. These findings suggest that in the process of formulating low-carbon oriented land-use and transport planning and policies, the indirect effects of the built environments should not be ignored, and the differences of the effects of the neighborhood built environments among different purposes of the trip should be fully considered.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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