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  • 1
    Online Resource
    Online Resource
    Biomechanics in Oncology (2018)
    Cham : Springer International Publishing
    Details Availability
    Keywords: Biomedical Engineering/Biotechnology ; Oncology   ; Oncology ; Oncology   ; Biomedical engineering ; Oncology ; Biomedical engineering ; Cancer research. ; Neoplasms ; Medical Oncology methods ; Biomechanical Phenomena ; Tumor Microenvironment ; Cell Physiological Phenomena ; Onkologie ; Biomechanik
    Description / Table of Contents: This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer
    Type of Medium: Online Resource
    Pages: Online-Ressource (XII, 376 p. 111 illus., 94 illus. in color, online resource)
    Edition: Springer eBook Collection. Biomedical and Life Sciences
    ISBN: 9783319952949
    Series Statement: Advances in Experimental Medicine and Biology 1092
    URL: https://doi.org/10.1007/978-3-319-95294-9
    URL: http://dx.doi.org/10.1007/978-3-319-95294-9
    DOI: 10.1007/978-3-319-95294-9
    RVK:
    XH 2553
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Faceting of tungsten(111) induced by ultrathin palladium films (1991)
    s.l. : American Chemical Society
    Langmuir 7 (1991), S. 3019-3026 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00060a019
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    PowderX: Windows-95-based program for powder X-ray diffraction data processing (1999)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 32 (1999), S. 838-838 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889899003039
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    LAPODS: a computer program for refinement of lattice parameters using optimal regression (2000)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 33 (2000), S. 1177-1179 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: LAPODS is an upgraded version of the program LAPOD for the refinement of lattice parameters using the method of Cohen [Langford (1971). J. Appl. Cryst. 4, 259–260]. The improved version has a number of advanced features. It can detect the most significant systematic errors automatically by means of a statistical F test; it can also operate in a manual mode with corrections set by the user or input manually. The single-value decomposition (SVD) method is used so that the refinement is now more stable. The general formula to calculate the specimen-transparency error has been incorporated and a transparency correction can now be made when the absorption is intermediate between the limiting cases of `thick' or `thin' samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889800006622
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  • 5
    Electronic Resource
    Electronic Resource
    The Expression of Cdk5, p35, p39, and Cdk5 Kinase Activity in Developing, Adult, and Aged Rat Brains (2000)
    Springer
    Neurochemical research 25 (2000), S. 923-929 
    Details
    ISSN: 1573-6903
    Keywords: Cdk5 ; p35 ; p39 ; cerebral cortex ; hippocampus ; development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression of cyclin-dependent kinase 5 (Cdk5) and its regulatory subunits, p35 and p39, was investigated in rat brain from embryonic day 12 (E12) to postnatal 18 months (18M). The Cdk5 protein levels increased from E12 to postnatal day 7 (P7) and remained at this level until 18M. The Cdk5 kinase activity and the levels of both p35 mRNA and protein were low at E12, became prominent at E18-P14 but then decreased in the adult and aged rat brains of 3M to 18M. In comparison, the expression pattern of p39 appeared to have an inverse relationship to that of Cdk5 and p35. In regional distribution studies, p35 protein levels and Cdk5 kinase activity were significantly higher in the cerebral cortex and hippocampus, but lower in the cerebellum and striatum. These results suggested that Cdk5, p35 and p39 might have region-specific and developmental stage-specific functions in rat brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007544106645
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  • 6
    Electronic Resource
    Electronic Resource
    Mechanics of Leukocyte Deformation and Adhesion to Endothelium in Shear Flow (1999)
    Springer
    Annals of biomedical engineering 27 (1999), S. 298-312 
    Details
    ISSN: 1573-9686
    Keywords: In vivo ; Incipient cell rolling ; Transient contact ; Drag force ; Modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The mechanics of leukocyte [white blood cell (WBC)] deformation and adhesion to endothelial cells (EC) in shear flow has been investigated. Experimental data on transient WBC–EC adhesion were obtained from in vivo measurements. Microscopic images of WBC–EC contact during incipient WBC rolling revealed that for a given wall shear stress, the contact area increases with time as new bonds are formed at the leading edge, and then decreases with time as the trailing edge of the WBC membrane peels away from the EC. A two-dimensional model (2D) was developed consisting of an elastic ring adhered to a surface under fluid stresses. This ring represents an actin-rich WBC cortical layer and contains an incompressible fluid as the cell interior. All molecular bonds are modeled as elastic springs distributed in the WBC–EC contact region. Variations of the proportionality between wall shear stress (τ w ) in the vicinity of the WBC and the resulting drag force (F s ), i.e., Fs/τw, reveal its decrease with WBC deformation and increasing vessel channel height (2D). The computations also find that the peeling zone between adherent WBC and EC may account for less than 5% of the total contact interface. Computational studies describe the WBC–EC adhesion and the extent of WBC deformation during the adhesive process. © 1999 Biomedical Engineering Society. PAC99: 8717-d, 8719Tt, 8717Aa
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1114/1.143
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  • 7
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    Development of front-end readout electronics for silicon strip detectors (2013)
    Institute of Physics (IOP)
    Details
    Publication Date: 2013-02-01
    Description: Front-end readout electronics have been developed for silicon strip detectors at our institute. In this system an Application Specific Integrated Circuit (ASIC) ATHED is used to realize multi-channel energy and time measurements. The slow control of ASIC chips is achieved by parallel port and the timing control signals of ASIC chips are implemented with the CPLD. The data acquisition is carried out with a PXI-DAQ card. The software has a user-friendly GUI developed with LabWindows/CVI in the Windows XP operating system. The test results show that the energy resolution is about 1.14% for alpha at 5.48 MeV and the maximum channel crosstalk of the system is 4.60%. The performance of the system is very reliable and is suitable for nuclear physics experiments.
    Print ISSN: 1674-1137
    Topics: Physics
    Published by Institute of Physics (IOP)
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  • 8
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    Enantioselective Construction of Polyfunctionalized Spiroannulated Dihydrothiophenes via a Formal Thio [3+2] Cyclization (2015)
    American Chemical Society (ACS)
    Details
    Publication Date: 2015-10-30
    Description: The Journal of Organic Chemistry DOI: 10.1021/acs.joc.5b01357
    Print ISSN: 0022-3263
    Electronic ISSN: 1520-6904
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 9
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    Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-07-16
    Description: ABSTRACT Polychlorinated biphenyls (PCBs), as typical environmental estrogen disruptors, are a structurally-related group of halogenated aromatic hydrocarbons that are composed of 209 isomers and present as a mixture in the environment. PCBs congener with different numbers and positions of chlorine atoms substituted on the biphenyl moiety. Aroclor-1254 is a mixture of more than 60 PCB congeners. Previous studies have provided the evidence that PCBs have severe negative effects on reproductive functions, but the effects of PCBs on spindle assembly during mouse oocyte maturation in vitro have not been reported. In the present study, female ICR mouse immature oocytes were cultured in M2 medium with 1 and 10 μg mL −1 Aroclor-1254 separately in vitro . The percentage of germinal vesicle breakdown (GVBD) and the first polar body extrusion were recorded. The results showed no significant difference in the percentage of GVBD or the first polar body extrusion between control oocytes and Aroclor-1254-treated oocytes. Further studies showed that the normal localization of γ-tubulin and Aurora-A kinase was interfered and α-tubulin assembling into spindle was affected when mouse oocytes were exposed to Aroclor-1254. The length of spindle from 10 μg mL −1 Aroclor-1254-treated oocytes was longer than that from control oocytes, and the spindle area in the Aroclor-1254-treated groups were decreased. Furthermore, the percentage of DNA damage in cumulus cells revealed an increase after exposed to Aroclor-1254. These results will provide the important reference for the prevention of reproductive disorders caused by PCBs. © 2015 Wiley Periodicals, Inc. Environ Toxicol, 2015.
    Print ISSN: 1520-4081
    Electronic ISSN: 1522-7278
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Wiley-Blackwell
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  • 10
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    Three-Dimensional Supramolecular Architectures with CoII Ions Assembled from Hydrogen Bonding and π···π Stacking Interactions: Crystal Structures and Antiferromagnetic Properties (2015)
    American Chemical Society (ACS)
    Details
    Publication Date: 2015-10-30
    Description: Crystal Growth & Design DOI: 10.1021/acs.cgd.5b01124
    Print ISSN: 1528-7483
    Electronic ISSN: 1528-7505
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Published by American Chemical Society (ACS)
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