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  • 1
    Electronic Resource
    Electronic Resource
    On Strongly Interacting Internal Solitary Waves (1995)
    Springer
    The journal of Fourier analysis and applications 2 (1995), S. 507-517 
    Details
    ISSN: 1531-5851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The Cauchy problem and global well-posedness for a mathematical model of the strong interaction of two-dimensional, long, internal gravity waves propogating on neighboring pycnoclines in a stratified fluid have been studied by Bona, Ponce, Saut, Tom, and others. We show that global well-posedness occurs even when the initial data is rough.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00041-001-4041-4
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  • 2
    Electronic Resource
    Electronic Resource
    Tetrandrine blocks a slow, large-conductance, Ca2+-activated potassium channel besides inhibiting a non-inactivating Ca2+ current in isolated nerve terminals of the rat neurohypophysis (1992)
    Springer
    Pflügers Archiv 421 (1992), S. 558-565 
    Details
    ISSN: 1432-2013
    Keywords: Calcium channels ; Calcium-activated potassium current ; Patch-clamp technique ; Posterior pituitary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of tetrandrine, a bis-benzyl-isoquinoline alkaloid, on voltage-gated Ca2+ currents (I Ca) and on Ca2+-activated K+ current (I K(Ca)) and channels in isolated nerve terminals of the rat neurohypophysis were investigated using patch-clamp techniques. The non-inactivating component of I Ca was inhibited by external tetrandrine in a voltage- and dose-dependent manner, with an IC50=10.1 μM. I K(Ca) was elicited by depolarizations when approximately 10 μM Ca2+ was present on the cytoplasmic side. Only externally applied tetrandrine, at 1 μM, decreased the amplitude of I K(Ca), whereas the fast inward Na+ current and transient outward K+ current were not affected. Tetrandrine, applied to the extracellular side of outside-out patches excised from the nerve terminals, induced frequent and short closures of single type II, maxi-Ca2+-activated K+channels. Tetrandrine decreased the channel-open probability, within bursts, with an IC50=0.21 μM. Kinetic analysis of the channel activity showed that the open-time constant decreased linearly with increasing tetrandrine concentrations (0.01–3 μM), giving an association rate constant of 8.8×108 M−1s−1, whereas the arithmetic mean closed time did not change, giving a dissociation rate constant of 136.6s−1. These results show that tetrandrine is a high-affinity blocker of the type II, maxi-Ca2+-activated K+ channel of the rat neurohypophysial terminals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00375051
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  • 3
    Electronic Resource
    Electronic Resource
    Enhanced Antitumor Activity of SarCNU in Comparison to BCNU in an Extraneuronal Monoamine Transporter Positive Human Glioma Xenograft Model (1999)
    Springer
    Journal of neuro-oncology 44 (1999), S. 7-14 
    Details
    ISSN: 1573-7373
    Keywords: extraneuronal monoamine transporter ; glioma ; SarCNU ; xenograft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A novel analogue of nitrosoureas, 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU), has demonstrated increased anticancer effects in vitro and in vivo. Our previous work suggested that SarCNU enters cells via the extraneuronal monoamine transporter (EMT), that contributes to its enhanced cytotoxicity. In the present study, comparative activities of SarCNU and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) were evaluated in an EMT positive human glioma xenograft model. Athymic nude mice implanted subcutaneously or intracranially with human glioma SHG-44, a cell line that has been confirmed EMT positive by using reverse-transcription polymerase chain reaction (RT-PCR) assay, were treated with SarCNU at an optimal dose of 167 mg/kg, or BCNU at 20 mg/kg or 30 mg/kg, q4d×3 intraperitoneally (i.p.). In 17 animals with subcutaneous tumor grafts treated with SarCNU, 9 animals became tumor free and 8 demonstrated tumor regression. While in the BCNU treated group, there were only 2 out of 10 mice in the 20 mg/kg group and 2 out of 7 in the 30 mg/kg group, which demonstrated some tumor regression. There were 4 drug related deaths in the BCNU (30 mg/kg) group, while there were no drug related deaths in the SarCNU group. In the intracranially implanted mice, the median survival time in the SarCNU group was more than 130 days, while in the BCNU treated group it was only 22 days which was similar to the control group (18 days). This is the first demonstration that SarCNU, in comparison to BCNU, has enhanced anticancer activity in an EMT positive human glioma xenograft model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006245724456
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  • 4
    Electronic Resource
    Electronic Resource
    Modular degeneracy of vacuum zero potential point and gauge transformations (1996)
    Springer
    International journal of theoretical physics 35 (1996), S. 2501-2505 
    Details
    ISSN: 1572-9575
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract This paper presents an extended gauge theory which can contain the Higgs mechanism, considering λφ4 field theory as an example. It can introduce interaction into different vacuum modular degeneracy states and break modular degeneracy. At the same time we can obtain both massless and massive vector bosons. According to the extended gauge theory, gauge transformations can be classified into two kinds: those with fixed parameter, called simply definite gauge transformations, which have a function of breaking modular degeneracy, and indefinite gauge transformations, which have a function of keeping phase degeneracy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02085758
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  • 5
    Electronic Resource
    Electronic Resource
    Jaynes-Cummings Model and Trapping of Atoms (1998)
    Springer
    International journal of theoretical physics 37 (1998), S. 2395-2401 
    Details
    ISSN: 1572-9575
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We present a semiclassical approach to thetrapping problem of atoms in the Jaynes-Cummings model.We express detuning in two ways, first by consideringdetuning as the superposition of many harmonic waves, ther other by establishing a relationshipbetween detuning and the distribution of the momentum ofatoms. In these two cases we find the appearance oftrapping atoms; we discuss the quantum chaotic movement of atoms irradiated with a stronglaser.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026619125914
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  • 6
    Electronic Resource
    Electronic Resource
    Classical Transport Theory for a Gluon Plasma (2000)
    Springer
    International journal of theoretical physics 39 (2000), S. 2513-2522 
    Details
    ISSN: 1572-9575
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The classical picture of a pure gluon plasma is given and classical transportequations for gluons in the system are derived and compared with quantumequations for gluons and classical equations for quarks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026497206317
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  • 7
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    Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-01-29
    Description: Nature Genetics 47, 158 (2015). doi:10.1038/ng.3178 Authors: Zheng Hu, Da Zhu, Wei Wang, Weiyang Li, Wenlong Jia, Xi Zeng, Wencheng Ding, Lan Yu, Xiaoli Wang, Liming Wang, Hui Shen, Changlin Zhang, Hongjie Liu, Xiao Liu, Yi Zhao, Xiaodong Fang, Shuaicheng Li, Wei Chen, Tang Tang, Aisi Fu, Zou Wang, Gang Chen, Qinglei Gao, Shuang Li, Ling Xi, Changyu Wang, Shujie Liao, Xiangyi Ma, Peng Wu, Kezhen Li, Shixuan Wang, Jianfeng Zhou, Jun Wang, Xun Xu, Hui Wang & Ding Ma Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis. By conducting whole-genome sequencing and high-throughput viral integration detection, we identified 3,667 HPV integration breakpoints in 26 cervical intraepithelial neoplasias, 104 cervical carcinomas and five cell lines. Beyond recalculating frequencies for the previously reported frequent integration sites POU5F1B (9.7%), FHIT (8.7%), KLF12 (7.8%), KLF5 (6.8%), LRP1B (5.8%) and LEPREL1 (4.9%), we discovered new hot spots HMGA2 (7.8%), DLG2 (4.9%) and SEMA3D (4.9%). Protein expression from FHIT and LRP1B was downregulated when HPV integrated in their introns. Protein expression from MYC and HMGA2 was elevated when HPV integrated into flanking regions. Moreover, microhomologous sequence between the human and HPV genomes was significantly enriched near integration breakpoints, indicating that fusion between viral and human DNA may have occurred by microhomology-mediated DNA repair pathways. Our data provide insights into HPV integration-driven cervical carcinogenesis.
    Print ISSN: 1061-4036
    Electronic ISSN: 1546-1718
    Topics: Biology , Medicine
    Published by Nature Publishing Group (NPG)
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  • 8
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    High-Tc superconductivity in ultrathin Bi2Sr2CaCu2O8+x down to half-unit-cell thickness by protection with graphene (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-12-10
    Description: Article So-called two-dimensional superconductivity has been reported in several material systems but just how thin a system can be and maintain a superconducting state has been difficult to determine. Da Jiang and colleagues demonstrate that Bi2Sr2CaCu2O8+ x continues to be superconducting even when it is just half a unit cell thick. Nature Communications doi: 10.1038/ncomms6708 Authors: Da Jiang, Tao Hu, Lixing You, Qiao Li, Ang Li, Haomin Wang, Gang Mu, Zhiying Chen, Haoran Zhang, Guanghui Yu, Jie Zhu, Qiujuan Sun, Chengtian Lin, Hong Xiao, Xiaoming Xie, Mianheng Jiang
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Molecular characterization and application of a novel cytoplasmic male sterility-associated mitochondrial sequence in rice (2015)
    BioMed Central
    Details
    Publication Date: 2015-05-01
    Description: Background: Cytoplasmic male sterility (CMS) is a maternally inherited inability to produce functional pollen found in numerous flowering plant species. CMS is associated with mitochondrial DNA mutation, novel chimeric open reading frames (ORFs), and rearrangement of coding and noncoding regions of the mitochondrial genome. Results: BLAST (Basic Local Alignment Search Tool) analysis indicated that L-sp1, a new sequence-characterized amplified region, is non-homologous to atp6-orfH79 (or atp6-orf79) and WA352 cloned CMS-associated genes. L-sp1 was found in 11 of 102 wild rice accessions belonging to four AA genome species: Oryza rufipogon, Oryza nivara, Oryza glumaepatula, and Oryza meridionalis. Using L-sp1, two new CMS lines were developed, from either low natural fertility plants or sterile plants, by backcrossing BC1F1 with Yuetai B. Northern blot and RT-PCR revealed that L-sp1 was only expressed in the anthers of w1/YTB, w2/YTB, w1/YTB//YTB, and w2/YTB//YTB when in the same cytoplasm background. Conclusions: L-sp1 is a single-copy chimeric CMS-associated gene found in the mitochondrial genome. It can be expressed in anthers with the same specific cytoplasm background, and will be a useful molecular marker for the development and marker-assisted selection of new CMS lines.
    Electronic ISSN: 1471-2156
    Topics: Biology
    Published by BioMed Central
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  • 10
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    A retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-03-18
    Description: We aimed to investigate the clinicoradiologic determinants of negative diffusion-weighted image (DWI) results in patients with acute cerebral infarction (ACI). The medical records were reviewed of ACI patients. Patients were divided to the DWI positive and negative group. Positive DWI was used as independent variable and patients' clinicoradiologic factors were used as co-variables for multivariate logistic regression analysis. 349 patients received initial cerebral MRI within 72 hours of admission. Lacunar infarction was most common (42.1%) followed by posterior circulation infarction (30.1%) and partial anterior circulation infarction (18.1%). The majority of the patients (72.2%) had an NIHSS score of less than 5 at admission. 316 patients (90.54%) were positive on initial DWI. Patients with smoking, initial SBP ≥ 140 or DBP ≥ 90 mmHg, initial fasting plasma glucose (FPG) ≥7.0 mmol/L, initial MRI from onset of disease 〉1 d and anterior circulation infarction were liable to show positive DWI. Furthermore, DWI negative patients had significantly lower NIHSS scores (IQR 0,1,2) than DWI positive patients (IQR 1,2,4) (P = 0.000) at two weeks post onset of acute cerebral infarction. In conclusion, multiple clinicoradiologic factors are associated with negative and positive DWI and further delineation of these factors is required in future prospective studies. Scientific Reports 5 doi: 10.1038/srep08910
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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