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  • BioMed Central  (4)
  • New York :Columbia University Press,  (2)
  • Blackwell Science Ltd  (1)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)
  • 1
    Online Resource
    Online Resource
    New York :Columbia University Press,
    Keywords: Mammals, Fossil - Asia. ; Electronic books.
    Description / Table of Contents: The first textbook devoted to the late Cenozoic (Neogene) mammalian biostratigraphy and geochronology of Asia, this volume deploys cutting edge biostratigraphical and geochemical dating methods to map the emergence of mammals across the continent. Written by specialists working in a variety of Asian regions, it uses data from many basins with spectacular fossil records to establish a groundbreaking geochronologic framework for land mammal evolution. Asia's violent tectonic history has resulted in some of the world's most varied topography, and its high mountain ranges and intense monsoon climates have spawned widely diverse environments over time. These geologic conditions profoundly influenced the evolution of Asian mammals and their migration into Europe, Africa, and North America. Focusing on amazing new fossil finds that have redefined Asia's role in mammal evolution, this textbook synthesizes information from a range of field studies on Asian mammals and biostratigraphy, helping to trace the histories and movements of extinct and extant mammals from various major groups and all northern continents, and providing geologists from all disciplines with a richer understanding of a variety of Asia's terrains.
    Type of Medium: Online Resource
    Pages: 1 online resource (759 pages)
    Edition: 1st ed.
    ISBN: 9780231520829
    DDC: 569.095
    Language: English
    Note: Intro -- { CONTENTS } -- Introduction: Toward a Continental Asian Biostratigraphic and Geochronologic Framework -- PART I: EAST ASIA -- 1. Neogene Land Mammal Staegs/Ages of China: Toward the Goal to Establish an Asian Land Mammal Stage/Age Scheme -- 2. North China Neogene Biochronology: A Chinese Standard -- 3. A Single-Point Base Definition of the Xiejian Age as an Exemplar for Refining Chinese Land Mammal Ages -- 4. Early Miocene Xiejiahe and Sihong Fossil Localities and Their Faunas, Eastern China -- 5. Neogene Faunal Succession and Biochronology of Central Nei Mongol (Inner Mongolia) -- 6. Mammalian Biochronology of the Late Miocene Bahe Formation -- 7. Stratigraphy and Paleoecology of the Classical Dragon Bone Localities of Baode County, Shanxi Province -- 8. Review of the Litho-, Bio-, and Chronostratigraphy in the Nihewan Basin, Hebei, China -- 9. Late Cenozoic Biostratigraphy of the Linxia Basin, Northwestern China -- 10. Neogene Mammalian Biostratigraphy and Geochrnology of the Tibetan Plateau -- 11. Hominoid-Producing Localities and Biostratigraphy in Yunnan -- 12. Miocene Land Mammals and Stratigraphy of Japan -- 13. Pliocene Land Mammals of Japan -- PART II: SOUTH AND SOUTHEAST ASIA -- 14. The Siwaliks and Neogene Evolutionary Biology in South Asia -- 15. The Neogene Siwaliks of the Potwar Plateau, Pakistan -- 16. Mammalian Neogene Biostratigraphy of the Sulaiman Province, Pakistan -- 17. Indian Neogene Siwalik Mammalian Biostratigraphy: An Overview -- 18. Paleobiogeography and South Asian Small Mammals: Neogene Latitudinal Faunal Variation -- 19. Advances in the Biochronology and Biostratigraphy of the Continental Neogene of Myanmar -- PART III: NORTH AND CENTRAL ASIA -- 20. Miocene Mammal Biostratigraphy of Central Mongolia (Valley of Lakes): New Results. , 21. Late Cenozoic Mammal Faunas of the Baikalian Region: Composition, Biochronology, Disperasal, and Correlation with Central Asia -- 22. New Data on Miocene Biostratigraphy and Paleoclimatology of Olkhon Islan (Lake Baikal, Siberia) -- PART IV: WEST ASIA AND ADJACENT REGIONS -- 23. Late Miocene Mammal Localities of Eastern Europe and Western Asia -- 24. Late Miocene (Turolian) Vertebrate Faunas from Southern European Russia -- 25. Recent Advances in Paleobiological Reserach of the Late Miocene Maragheh Fauna, Northwest Iran -- 26. A Review of the Neogene Succession of the Muridae and Dipodidae from Anatolia, wiht Special Reference to Taxa Known from Asia and/or Europe -- 27. Late Miocene Fossils from the Baynunah Formation, United Arab Emirates: Summary of a Decade of New Work -- 28. Neogene Mammal Biostratigraphy and Chronology of Greece -- PART V: ZOOGEOGRAPHY AND PALEOECOLOGY -- 29. Contintental-Scale Patterns in Neogene Mammal Community Evolution and Biogeography: A Europe-Asia Perspective -- 30. Intercontinental Dispersals of Sicistine Rodents (Sicistinae, Dipodidae, Rodentia) Between Eurasia and North America -- 31. Paeleodiatary Comparisons of Ungulates Between the Late Miocene of China, and Pikermi and Samos in Greece -- List of Contributors -- Taxonomic Index -- General Index.
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  • 2
    Online Resource
    Online Resource
    New York :Columbia University Press,
    Keywords: Dogs. ; Canis, Fossil. ; Dogs--Evolution. ; Electronic books.
    Description / Table of Contents: No detailed description available for "Dogs".
    Type of Medium: Online Resource
    Pages: 1 online resource (303 pages)
    Edition: 1st ed.
    ISBN: 9780231509435
    DDC: 599.77/2
    Language: English
    Note: Intro -- Cover -- Half title -- Title -- Copyright -- Contents -- Preface -- Acknowledgments -- 1. Methods of Study and the Place of Dogs in Nature -- 2. The Origin of Canids and Other Doglike Carnivorous Mammals -- 3. Diversity: Who Is Who in the Dog Family -- 4. Anatomy and Function: How the Parts Work -- 5. Hunting and Social Activity -- 6. Changing Environments and Canid Evolution -- 7. Going Places: Braving New Worlds -- 8. Domestic Dogs -- Appendix 1. Canid Species and Classification -- Appendix 2. Phylogenetic Tree of the Family Canidae -- Glossary -- Further Reading -- Index -- List of Plates.
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  • 3
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A 20-kDa DNA-binding protein that binds the AT-rich sequences within the promoters of the brain-specific protein kinase C (PKC) γ and neurogranin/RC3 genes has been characterized as chromosomal nonhistone high-mobility-group protein (HMG)-I. This protein is a substrate of PKC α, β, γ, and δ but is poorly phosphorylated by PKC ε and ζ. Two major (Ser44 and Ser64) and four minor phosphorylation sites have been identified. The extents of phosphorylation of Ser44 and Ser64 were 1:1, whereas those of the four minor sites all together were 〈30% of the major one. These PKC phosphorylation sites are distinct from those phosphorylated by cdc2 kinase, which phosphorylates Thr53 and Thr78. Phosphorylation of HMG-I by PKC resulted in a reduction of DNA-binding affinity by 28-fold as compared with 12-fold caused by the phosphorylation with cdc2 kinase. HMG-I could be additively phosphorylated by cdc2 kinase and PKC, and the resulting doubly phosphorylated protein exhibited a 〉 100-fold reduction in binding affinity. The two cdc2 kinase phosphorylation sites of HMG-I are adjacent to the N terminus of two of the three predicted DNA-binding domains. In comparison, one of the major PKC phosphorylation sites, Ser64, is adjacent to the C terminus of the second DNA-binding domain, whereas Ser44 is located within the spanning region between the first and second DNA-binding domains. The current results suggest that phosphorylation of the mammalian HMG-I by PKC alone or in combination with cdc2 kinase provides an effective mechanism for the regulation of HMG-I function.
    Type of Medium: Electronic Resource
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  • 4
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    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Publication Date: 2017-01-21
    Description: Protein posttranslational modifications such as neddylation play crucial roles in regulating protein function. Only a few neddylated substrates have been validated to date, and the role of neddylation remains poorly understood. Here, using Trypanosoma brucei as the model organism, we investigated the function and substrates of TbNedd8. TbNedd8 is distributed throughout the cytosol but enriched in the nucleus and the flagellum. Depletion of TbNedd8 by RNAi abolished global protein ubiquitination, caused DNA re-replication in postmitotic cells, impaired spindle assembly, and compromised the flagellum attachment zone filament, leading to flagellum detachment. Through affinity purification and mass spectrometry, we identified 70 TbNedd8-conjugated and -associated proteins, including known Nedd8-conjugated and -associated proteins, putative TbNedd8 conjugation system enzymes, proteins of diverse biological functions, and proteins of unknown function. Finally, we validated six Cullins as bona fide TbNedd8 substrates and identified the TbNedd8 conjugation site in three Cullins. This work lays the foundation for understanding the roles of protein neddylation in this early divergent parasitic protozoan.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
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  • 5
    Publication Date: 2015-03-25
    Description: Background: Necrosis of alveolar macrophages following Mycobacterium tuberculosis infection has been demonstrated to play a vital role in the pathogenesis of tuberculosis. Our previous study demonstrated that Wnt/β-catenin signaling was able to promote mycobacteria-infected cell apoptosis by a caspase-dependent pathway. However, the functionality of this signaling in the necrosis of macrophage following mycobacterial infection remains largely unknown. Methods: Murine macrophage RAW264.7 cells were infected with Bacillus Calmette-Guerin (BCG) in the presence of Wnt/β-catenin signaling. The necrotic cell death was determined by cytometric assay and electronic microscopy; the productions of reactive oxygen species (ROS) and reduced glutathione (GSH) were measured by a cytometric analysis and an enzyme-linked immunosorbent assay, respectively; and the activity of poly (ADP-ribose) polymerase 1 (PARP-1)/apoptosis inhibition factor (AIF) signaling was examined by an immunoblotting assay. Results: The BCG can induce RAW264.7 macrophage cells necrosis in a dose- and time-dependent manner along with an accumulation of reactive oxygen species (ROS). Intriguingly, an enhancement of Wnt/β-catenin signaling shows an ability to reduce the mycobacteria-induced macrophage necrosis. Mechanistically, the activation of Wnt/β-catenin signaling is capable of inhibiting the necrotic cell death in BCG-infected RAW264.7 cells through a mechanism by which the Wnt signaling scavenges intracellular ROS accumulation and increases cellular GSH concentration. In addition, immunoblotting analysis further reveals that Wnt/β-catenin signaling is capable of inhibiting the ROS-mediated cell necrosis in part through a PARP-1/AIF- dependent pathway. Conclusions: An activation of Wnt/β-catenin signaling can inhibit BCG-induced macrophage necrosis by increasing the production of GSH and scavenging ROS in part through a mechanism of repression of PARP-1/AIF signaling pathway. This finding may thus provide an insight into the underlying mechanism of alveolar macrophage cell death in response to mycobacterial infection.
    Electronic ISSN: 1471-2172
    Topics: Medicine
    Published by BioMed Central
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  • 6
    Publication Date: 2015-07-04
    Description: Background: The purpose of this study was to examine the choroidal thickness of patients with high myopia using enhanced depth imaging optical coherence tomography (EDI-OCT) and compare them with healthy subjects. Methods: We first conducted a cross-sectional study and then performed a meta-analysis to address this issue further. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the macular choroidal thickness of high myopic eyes and normal control eyes were measured and compared at each location. Univariate and multivariate linear regression analyses were performed to assess the association between choroidal thickness and clinical factors such as axial length (AL), spherical equivalent (SE), and central corneal thickness. In the high myopic eyes, subgroup analysis of macular choroidal thickness was performed in eyes with or without lacquer cracks and choroidal neovascularization (CNV). The meta-analyses were conducted using the Stata software package. Results: The high myopic eyes had a thinner choroid than the control eyes at all macular locations (all P 
    Electronic ISSN: 1471-2415
    Topics: Medicine
    Published by BioMed Central
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  • 7
    Publication Date: 2015-04-30
    Description: Background: Hepatocyte carcinoma (HCC) is one of the most common malignancies worldwide. Despite many achievements in diagnosis and treatment, HCC mortality remains high due to the malignant nature of the disease. Novel approaches, especially for targeted therapy, are being extensively explored. Gene therapy is ideal for such purpose for its specific expression of exogenous genes in HCC cells driven by tissue-specific promoter. However strategies based on correction of mutations or altered expressions of genes responsible for the development/progression of HCC have limitations because these aberrant molecules are not presented in all cancerous cells. In the current work, we adopted a novel strategy by targeting the DNA replication step which is essential for proliferation of every cancer cell. Methods: A recombinant adenovirus with alpha fetoprotein (AFP) promoter-controlled expressions of artificial microRNAs targeting DNA polymerases α, δ, ε and recombinant active Caspase 3, namely Ad/AFP-Casp-AFP-amiR, was constructed. Results: The artificial microRNAs could efficiently inhibit the expression of the target polymerases in AFP-positive HCC cells at both RNA and protein levels, and HCC cells treated with the recombinant virus Ad/AFP-Casp-AFP-amiR exhibited significant G0/1 phase arrest. The proliferation of HCC cells were significantly inhibited by Ad/AFP-Casp-AFP-amiR with increased apoptosis. On the contrary, the recombinant adenovirus Ad/AFP-Casp-AFP-amiR did not inhibit the expression of DNA polymerases α, δ or ε in AFP-negative human normal liver cell HL7702, and showed no effect on the cell cycle progression, proliferation or apoptosis. Conclusions: Inhibition of DNA polymerases α, δ and ε by AFP promoter-driven artificial microRNAs may lead to effective growth arrest of AFP-positive HCC cells, which may represent a novel strategy for gene therapy by targeting the genes that are essential for the growth/proliferation of cancer cells, avoiding the limitations set by any of the individually altered gene.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
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  • 8
    Publication Date: 2016-06-09
    Description: The purpose of this study was to compare the efficacy and tolerability of the Ahmed glaucoma valve (AGV) implant and the Baerveldt implant for the treatment of refractory glaucoma.
    Electronic ISSN: 1471-2415
    Topics: Medicine
    Published by BioMed Central
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