In:
Beilstein Journal of Organic Chemistry, Beilstein Institut, Vol. 8 ( 2012-06-11), p. 861-869
Kurzfassung:
We describe the unprecedented formation of six ansamitocin derivatives that are deoxygenated at C-7 of the ansamitocin core, obtained during fermentation experiments by employing a variety of Actinosynnema pretiosum mutants and mutasynthetic approaches. We suggest that the formation of these derivatives is based on elimination at C-7/C-8 followed by reduction(s) of the intermediate enone. In bioactivity tests, only ansamitocin derivatives bearing an ester side chain at C-3 showed strong antiproliferative activity.
Materialart:
Online-Ressource
ISSN:
1860-5397
Sprache:
Englisch
Verlag:
Beilstein Institut
Publikationsdatum:
2012
ZDB Id:
2192461-2
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