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  • 11
    Electronic Resource
    Electronic Resource
    Large magnetoresistance in La1−xSrxMnO3 and its dependence on magnetization (1995)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 66 (1995), S. 233-235 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this letter we report large magnetoresistance (MR) in ceramic samples of La1−xSrxMnO3 (0.1≤x≤0.4) in the temperature range 4.2 K≤T≤350 K in fields up to 6 T. We find that a large negative and isotopic MR exists for the whole composition range studied and the absolute value of resistivity change on application of magnetic field is more for samples with lower x which have higher resistivity. We find that the large MR occurs in the ferromagnetic state only and MR has a close relation with the magnetization M. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.113556
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    In situ all-laser process for deposition of Y1Ba2Cu3O7−δ film on stainless steel involving use of Y-ZrO2-Ag composite as a barrier layer (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 59 (1991), S. 1908-1910 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Highly c-axis oriented good-quality (Tc of 88 K and Jc of 105 A/cm2 at 20 K) thin films of Y1Ba2Cu3O7−δ have been deposited on stainless-steel substrates by an in situ all-laser process involving use of laser-deposited Y-ZrO2-Ag composite film as a barrier layer. These results are compared with those obtained for the case of the use of a bilayer configuration of Ag and Y-ZrO2 to emphasize the importance of employing a composite film as a barrier layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.106185
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  • 13
    Electronic Resource
    Electronic Resource
    Nanocomposites by fractal growth of electrodeposited silver in ion-exchanged oxide glasses (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 59 (1991), S. 1415-1417 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Clusters of metallic silver have been formed by electrodeposition within the surface of an oxide glass which was subjected to an alkali silver ion exchange process. The clusters have a fractal structure with a Hausdorff dimension D around 1.86 over a length scale 10–140 μm. Electron micrograph of the sample indicates the possibility of a crossover to a nonfractal regime at length scales of the order of a few hundred nanometers. The fractal growth within the glass results in the formation of a glass metal nanocomposite with a particle diameter around 12 nm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.105324
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  • 14
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    CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel (2013)
    Oxford University Press
    Details
    Publication Date: 2013-05-22
    Description: Background Paclitaxel-induced neuropathy is an adverse event that often leads to therapeutic disruption and patient discomfort. We attempted to replicate a previously reported association between increased neuropathy risk and CYP2C8*3 genotype. Patients and methods Demographic, treatment, and toxicity data were collected for paclitaxel-treated breast cancer patients who were genotyped for the CYP2C8*3 K399R (rs10509681) variant. A log-rank test was used in the primary analysis of European-American patients. An additional independent replication was then attempted in a cohort of African-American patients, followed by modeling of the entire patient cohort with relevant covariates. Results In the primary analysis of 209 European patients, there was an increased risk of paclitaxel-induced neuropathy related to CYP2C8*3 status [HR (per allele) = 1.93 (95% CI: 1.05–3.55), overall log-rank P = 0.006]. The association was replicated in direction and magnitude of effect in 107 African-American patients ( P = 0.043). In the Cox model using the entire mixed-race cohort ( n = 411), each CYP2C8*3 allele approximately doubled the patient's risk of grade 2+ neuropathy ( P = 0.004), and non-Europeans were at higher neuropathy risk than Europeans of similar genotype ( P = 0.030). Conclusions The increased risk of paclitaxel-induced neuropathy in patients who carry the CYP2C8*3 variant was replicated in two racially distinct patient cohorts.
    Print ISSN: 0923-7534
    Electronic ISSN: 1569-8041
    Topics: Medicine
    Published by Oxford University Press
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  • 15
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    Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival (2013)
    Oxford University Press
    Details
    Publication Date: 2013-05-22
    Description: Background Ipilimumab is a recently approved immunotherapy that has demonstrated an improvement in the overall survival (OS) of patients with metastatic melanoma. We report a single-institution experience in patients treated in a compassionate-use program. Patients and methods In this prospective study, patients were treated between June 2010 and September 2011. Inclusion criteria were a diagnosis of unresectable stage III or IV melanoma, at least one previous line of chemotherapy, and survival 12 weeks after the first perfusion. Four courses of ipilimumab were administered at a dose of 3 mg/kg every 3 weeks. Results Seventy-three patients were included. Median OS was 9.1 months (95% CI 6.4–11.3) from the start of ipilimumab. Immune-related adverse events were observed in 45 patients (62%), including 19 grade 3–4 events (26%). No drug-related death occurred. A lymphocyte count 〉1000/mm 3 at the start of the second course and an increase in the eosinophil count 〉100/mm 3 between the first and second infusions were correlated with an improved OS. Conclusion Ipilimumab toxic effect is manageable in real life. Biological data such as lymphocyte and eosinophil counts at the time of the second ipilimumab infusion appear to be early markers associated with better OS.
    Print ISSN: 0923-7534
    Electronic ISSN: 1569-8041
    Topics: Medicine
    Published by Oxford University Press
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  • 16
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    Magnetic fields in nearby normal galaxies: energy equipartition (2013)
    Oxford University Press
    Details
    Publication Date: 2013-07-04
    Description: We present maps of total magnetic field using ‘equipartition’ assumptions for five nearby normal galaxies at sub-kpc spatial resolution. The mean magnetic field is found to be ~ 11 μG. The field is strongest near the central regions where mean values are ~ 20-25 μG and fall to ~ 15 μG in disc and ~ 10 μG in the outer parts. There is little variation in the field strength between arm and interarm regions, such that, in the interarms, the field is 20 per cent weaker than in the arms. There is no indication of variation in magnetic field as one moves along arm or interarm after correcting for the radial variation of magnetic field. We also studied the energy densities in gaseous and ionized phases of the interstellar medium and compared to the energy density in the magnetic field. The energy density in the magnetic field was found to be similar to that of the gas within a factor of 2 at sub-kpc scales in the arms, and thus magnetic field plays an important role in pressure balance of the interstellar medium. Magnetic field energy density is seen to dominate over the kinetic energy density of gas in the interarm regions and outer parts of the galaxies and thereby helps in maintaining the large-scale ordered fields seen in those regions.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 17
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    Spin-phonon coupling in scandium doped gallium ferrite (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-03-31
    Description: We embarked on a study of Scandium (Sc) doped (onto Ga site) gallium ferrite (GaFeO 3 ) and found remarkable magnetic properties. In both doped as well as parent compounds, there were three types of Fe 3+ ions (depending on the symmetry) with the structure conforming to space group Pna2 1 (Sp. Grp. No. 33) below room temperature down to 5 K. We also found that all Fe 3+ ions occupy octahedral sites, and carry high spin moment. For the higher Sc substituted sample (Ga 1− x Sc x FeO 3 : x = 0.3), a canted magnetic ordered state is found. Spin-phonon coupling below Néel temperature was observed in doped compounds. Our results indicated that Sc doping in octahedral site modifies spin-phonon interactions of the parent compound. The spin-phonon coupling strength was estimated for the first time in these Sc substituted compounds.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 18
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    Synchrotron spectral index and interstellar medium densities of star-forming galaxies (2015)
    Oxford University Press
    Details
    Publication Date: 2015-04-12
    Description: The spectral index of synchrotron emission is an important parameter in understanding the properties of cosmic ray electrons (CREs) and the interstellar medium (ISM). We determine the synchrotron spectral index (α nt ) of four nearby star-forming galaxies, namely NGC 4736, NGC 5055, NGC 5236 and NGC 6946 at sub-kpc linear scales. The α nt was determined between 0.33 and 1.4 GHz for all the galaxies. We find the spectral index to be flatter ( –0.7) in regions with total neutral (atomic + molecular) gas surface density, gas 50 M pc – 2 , typically in the arms and inner parts of the galaxies. In regions with gas 50 M pc – 2 , especially in the interarm and outer regions of the galaxies, the spectral index steepens sharply to 〈–1.0. The flattening of α nt is unlikely to be caused due to thermal free–free absorption at 0.33 GHz. Our result is consistent with the scenario where the CREs emitting at frequencies below ~0.3 GHz are dominated by bremsstrahlung and/or ionization losses. For denser medium ( gas 200 M pc – 2 ), having strong magnetic fields ( ~ 30 μG), α nt is seen to be flatter than –0.5, perhaps caused due to ionization losses. We find that, due to the clumpy nature of the ISM, such dense regions cover only a small fraction of the galaxy (5 per cent). Thus, the galaxy-integrated spectrum may not show indication of such loss mechanisms and remain a power law over a wide range of radio frequencies (between ~0.1 to 10 GHz).
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 19
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    Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics (2015)
    Oxford University Press
    Details
    Publication Date: 2015-08-18
    Description: Classically or alternatively activated macrophages (M1 and M2, respectively) play distinct and important roles for microbiocidal activity, regulation of inflammation and tissue homeostasis. Despite this, their transcriptional regulatory dynamics are poorly understood. Using promoter-level expression profiling by non-biased deepCAGE we have studied the transcriptional dynamics of classically and alternatively activated macrophages. Transcription factor (TF) binding motif activity analysis revealed four motifs, NFKB1_REL_RELA, IRF1,2, IRF7 and TBP that are commonly activated but have distinct activity dynamics in M1 and M2 activation. We observe matching changes in the expression profiles of the corresponding TFs and show that only a restricted set of TFs change expression. There is an overall drastic and transient up-regulation in M1 and a weaker and more sustainable up-regulation in M2. Novel TFs, such as Thap6, Maff , (M1) and Hivep1, Nfil3, Prdm1 , (M2) among others, were suggested to be involved in the activation processes. Additionally, 52 (M1) and 67 (M2) novel differentially expressed genes and, for the first time, several differentially expressed long non-coding RNA (lncRNA) transcriptome markers were identified. In conclusion, the finding of novel motifs, TFs and protein-coding and lncRNA genes is an important step forward to fully understand the transcriptional machinery of macrophage activation.
    Keywords: Genomics
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 20
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    Magnetically tunable alternating current electrical properties of x La0.7Sr0.3MnO3–(1 − x) ErMnO3 (x = 0.1, 0.3, and 0.5) multiferroic nanocomposite (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-07-30
    Description: Detailed magnetically tunable ac electrical properties of x La 0.7 Sr 0.3 MnO 3 (LSMO)–(1 − x) ErMnO 3 (EMO) (x = 0.1, 0.3, and 0.5) multiferroic nanocomposites have been studied at 300 K in presence of varying magnetic field (H appl ), applied both in parallel and perpendicular configuration with respect to the measuring electric field. AC electrical properties have exhibited significant variation with H appl for all composites, whereas for parallel configuration of H appl such effect is very feeble for x = 0.3 composite. We have attributed this anisotropic behavior to the demagnetization effect in the sample. In contrast, for x = 0.1 and 0.5 composites, no such anisotropy effect is experimentally evidenced. Impedance and real part of impedance have been found to decrease with H appl at low frequency ( f ) region. We attribute this observation to the depinning of the magnetic domain walls from the grain boundaries pinning centers and thereby enhancing the spin dependent transport in the composite. For x = 0.3 composite, Nyquist plots have been fitted considering dominant contributions of LSMO and EMO grain boundaries and the interface region between them. However, for x = 0.1 composite, it corresponds to EMO grain boundaries and grain boundary interface region. The relaxation frequency ( f R ) is observed to shift at higher/lower f region in perpendicular/parallel configuration of H appl for x = 0.3 composite. This opposite variation of f R s with H appl for perpendicular and parallel configurations has been attributed to two competing factors of H appl induced enhancement of inductive part and H appl enhanced spin dependent transport causing fast relaxation processes in the sample. For x = 0.1 composite, in both configurations of H appl , f R s is shifting towards high f region, which has been discussed in terms of dominant role of spin dependent transport.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
    Published by American Institute of Physics (AIP)
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