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  • 1
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2016. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 121 (2016): 3161–3176, doi:10.1002/2016JB012928.
    Description: Near-bottom magnetic field measurements made by the submersible Nautile during the 1992 Kanaut Expedition define the cross-sectional geometry of magnetic polarity reversal boundaries and the vertical variation of crustal magnetization in lower oceanic crust exposed along the Kane Transform Fault (TF) at the northern boundary of the Kane Megamullion (KMM). The KMM exposes lower crust and upper mantle rocks on a low-angle normal fault that was active between 3.3 Ma and 2.1 Ma. The geometry of the polarity boundaries is estimated from an inversion of the submarine magnetic data for crustal magnetization. In general, the polarity boundaries dip away from the ridge axis along the Kane TF scarp, with a west dipping angle of ~45° in the shallow (〈1 km) crust and 〈20° in the deeper crust. The existence of the magnetic polarity boundaries (e.g., C2r.2r/C2An.1n, ~2.581 Ma) indicates that the lower crustal gabbros and upper mantle serpentinized peridotites are able to record a coherent magnetic signal. Our results support the conclusion of Williams (2007) that the lower crust cools through the Curie temperature of magnetite to become magnetic, with the polarity boundaries representing both frozen isotherms and isochrons. We also test the effects of the rotation of this isotherm structure and/or footwall rotation and find that the magnetic polarity boundary geometry is not sensitive to these directional changes.
    Description: 2016-11-12
    Keywords: Kane Megamullion ; Vertical magnetic profile ; Magnetic polarity reversal ; Mid-Atlantic Ridge
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
    Publication Date: 2022-05-26
    Description: Author Posting. © American Geophysical Union, 2017. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 122 (2017): 9518–9529, doi:10.1002/2017JC013310.
    Description: Microseisms generated by the super typhoon Megi (13–24 October 2010) were detected on both land-based and island-based seismic stations. We applied temporal frequency spectrum analysis to investigate the temporal evolution of the microseisms. When Megi was over the deep basins of the Philippine Sea, only weak microseisms with short-period double frequency (SPDF, ∼0.20–0.40 Hz) were observed. However, after Megi traveled into the shallower waters of the South China Sea, microseisms with both long-period double frequency (LPDF, ∼0.12–0.20 Hz) and SPDF were recorded. The excitation source regions of the microseisms were analyzed using seismic waveform records and synthetic modeling in frequency domain. Results reveal that part of the LPDF microseisms were excited in coastal source regions, while the intensity of both LPDF and SPDF microseisms correlated well with the distance from seismic stations to the typhoon center. Synthetic computations of equivalent surface pressure and corresponding microseisms show that the wave-to-wave interaction induced by coastal reflection has primary effects on microseismic frequency band of ∼0.10–0.20 Hz. The coastal generation of the dispersive LPDF microseisms is also supported by the observation of ocean swells induced by Megi through the images of C-band ENVISAT-ASAR satellite during its migration process. Two source regions of the microseisms during the life span of Megi are finally distinguished: One was mainly located in the left-rear quadrant of the typhoon center that generated both LPDF and SPDF microseisms at shallow seas, while the other one was near the coasts that generated mostly LPDF microseisms.
    Description: National Natural Science Foundation of China Grant Numbers: 41104027, 91628301, U1606401, 41676044; Natural Science Foundation of Zhejiang Province Grant Number: LZ14D060001; Opening Fund of SKLGED Grant Number: SKLGED2013-1-7-E; Chinese Academy of Sciences Grant Numbers: Y4SL021001, Y6YB011001, QYZDY-SSW-DQC005
    Description: 2018-06-07
    Keywords: Microseisms ; Typhoon ; Ocean wave ; Source region ; Generation mechanism
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 3
    Publication Date: 2022-05-26
    Description: Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 119 (2014): 2721–2744, doi:10.1002/2013JB010730.
    Description: We use three-dimensional multistreamer seismic reflection data to investigate variations in axial magma lens (AML) physical properties along the East Pacific Rise between 9°30′N and 10°00′N. Using partial-offset stacks of P- and S-converted waves reflecting off the top of the AML, we image four 2–4 km long melt-rich sections spaced 5–10 km from each other. One-dimensional waveform inversion indicates that the AML in a melt-rich section is best modeled with a low Vp (2.95–3.23 km/s) and Vs (0.3–1.5 km/s), indicating 〉70% melt fraction. In contrast, the AML in a melt-poor section requires higher Vp (4.52–4.82 km/s) and Vs (2.0–3.0 km/s), which indicates 〈40% melt fraction. The thicknesses of the AML are constrained to be 8–32 m and 8–120 m at the melt-rich and -poor sites, respectively. Based on the AML melt-mush segmentation imaged in the area around the 2005–2006 eruption, we infer that the main source of this eruption was a 5 km long section of the AML between 9°48′N and 51′N. The eruption drained most of the melt in this section of the AML, leaving behind a large fraction of connected crystals. We estimate that during the 2005–2006 eruption, a total magma volume of 9–83 × 106 m3 was extracted from the AML, with a maximum of 71 × 106 m3 left unerupted in the crust as dikes. From this, we conclude that an eruption of similar dimensions to the 2005–2006, one would be needed with a frequency of years to decades in order to sustain the long-term average seafloor spreading rate at this location.
    Description: This research was supported by NSF grants OCE-0327885 and OCE-0327872 through the RIDGE-2000 program.
    Description: 2014-10-29
    Keywords: East Pacific Rise ; Seismic structure ; Melt lens
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 4
    Publication Date: 2018-03-30
    Description: Rationale:Human pluripotent stem cell–derived cardiovascular progenitor cells (hPSC-CVPCs) should be thoroughly investigated in large animal studies before testing in clinical trials.Objective:The main of this study is to clarify whether hPSC-CVPCs can engraft for long time in the heart of primates after myocardial infarction (MI) and compare the effectiveness and safety of immunosuppression with cyclosporine alone or multiple-drug regimen (MDR) containing cyclosporine, methylprednisolone, and basiliximab in cynomolgus monkeys that had received intramyocardial injections of 1×107 EGFP (enhanced green fluorescent protein)-expressing hPSC-CVPCs after MI. A third group of animals received the immunosuppression MDR but without cell therapy after MI (MI+MDR group).Methods and Results:Measurements of EGFP gene levels and EGFP immunofluorescence staining indicated that the hPSC-CVPC engraftment rate was greater in the MI+MDR+CVPC group than that in the MI+cyclosporine+CVPC group. However, even in the MI+MDR+CVPC group, no transplanted cells could be detected at 140 days after transplantation. Concomitantly, immunofluorescent analysis of CD3, CD4, and CD8 expression indicated that T-lymphocyte infiltration in the CVPC-transplanted hearts was less in the MDR-treated animals than in the cyclosporine-alone–treated animals. The recovery of left ventricular function on day 28 post-MI in the MI+MDR+CVPC group was better than that in the MI+MDR group. Apoptotic cardiac cells were also less common in the MI+MDR+CVPC group than in the MI+MDR group, although both immunosuppression regimens were associated with transient hepatic dysfunction.Conclusions:This is the largest study of hPSCs in nonhuman primates in cardiovascular field to date (n=32). Compared with cyclosporine alone, MDR attenuates immune rejection and improves survival of hPSC-CVPCs in primates; this is associated with less apoptosis of native cardiac cells and better recovery of left ventricular function at 28 days. However, even with MDR, transplanted hPSC-CVPCs do not engraft and do not survive at 140 days after transplantation, thereby excluding remuscularization as a mechanism for the functional effect.
    Keywords: Stem Cells, Myocardial Infarction
    Print ISSN: 0009-7330
    Electronic ISSN: 1524-4571
    Topics: Medicine
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  • 5
    Publication Date: 2016-12-22
    Description: Objective—We aimed to examine whether baseline homocysteine (Hcy) concentrations affect antihypertensive responses to enalapril treatment among previously untreated hypertensive patients (n=10 783) in the CSPPT (China Stroke Primary Prevention Trial).Approach and Results—After a 3-week run-in treatment with a daily dose of 10 mg enalapril, eligible hypertensive patients were randomly assigned to a double-blind daily treatment of a tablet of either enalapril (10 mg) and folic acid (0.8 mg) or enalapril (10 mg) alone for a median of 4.5 years. After the 3-week treatment period with enalapril alone, the systolic blood pressure–lowering effect was significantly reduced by 1.39 (95% confidence interval 0.40–2.37) and 3.25 (95% confidence interval 1.98–4.52) mm Hg, respectively, in those with baseline Hcy concentrations of 10 to 15 and ≥15 μmol/L (P for trend
    Keywords: ACE/Angiotensin Receptors/Renin Angiotensin System, Clinical Studies, Diet and Nutrition, Risk Factors, Hypertension
    Print ISSN: 1079-5642
    Electronic ISSN: 1524-4636
    Topics: Medicine
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