GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Hidden upwelling systems associated with major western boundary currents (2022)
    American Geophysical Union
    Details
    Publication Date: 2022-10-26
    Description: © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Liao, F., Liang, X., Li, Y., & Spall, M. Hidden upwelling systems associated with major western boundary currents. Journal of Geophysical Research: Oceans. 127, (2022): e2021JC017649, https://doi.org/10.1029/2021jc017649.
    Description: Western boundary currents (WBCs) play an essential role in regulating global climate. In contrast to their widely examined horizontal motions, less attention has been paid to vertical motions associated with WBCs. Here, we examine vertical motions associated with the major WBCs by analyzing vertical velocity from five ocean synthesis products and one eddy-resolving ocean simulation. These data reveal robust and intense subsurface upwelling systems, which are primarily along isopycnal surfaces, in five major subtropical WBC systems. These upwelling systems are part of basin-scale overturning circulations and are likely driven by meridional pressure gradients along the western boundary. Globally, the WBC upwelling contributes significantly to the vertical transport of water mass and ocean properties and is an essential yet overlooked branch of the global ocean circulation. In addition, the WBC upwelling intersects the oceanic euphotic and mixed layers, and thus likely plays an important role in ocean biological and chemical processes by transporting nutrients, carbon and other tracers vertically inside the ocean. This study calls for more research into the dynamics of the WBC upwelling and their role in the ocean and climate systems.
    Description: X. Liang is supported by the National Science Foundation through Grants OCE-2021274, OCE-2122507, and the Alfred P. Sloan Foundation through Grant FG-2019-12536. M. Spall is supported through the National Science Foundation Grants OCE-1947290 and OCE-2122633.
    Keywords: Western boundary current ; Upwelling ; Overturning circulation ; Ocean vertical transport ; Ocean synthesis products ; Ocean vertical velocity
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 2
    facet.materialart.
    Unknown
    Variations in rates of biological production in the Beaufort Gyre as the arctic changes: Rates from 2011 to 2016 (2019)
    American Geophysical Union
    Details
    Publication Date: 2022-10-26
    Description: Author Posting. © American Geophysical Union, 2019. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research-Oceans 124(6), (2019): 3628-3644, doi:10.1029/2018JC014805.
    Description: The Arctic Ocean is experiencing profound environmental changes as the climate warms. Understanding how these changes will affect Arctic biological productivity is key for predicting future Arctic ecosystems and the global CO2 balance. Here we use in situ gas measurements to quantify rates of gross oxygen production (GOP, total photosynthesis) and net community production (NCP, net CO2 drawdown by the biological pump) in the mixed layer in summer or fall from 2011 to 2016 in the Beaufort Gyre. NCP and GOP show spatial and temporal variations with higher values linked with lower concentrations of sea ice and increased upper ocean stratification. Mean rates of GOP range from 8 ± 1 to 54 ± 9 mmol O2·m−2·d−1 with the highest mean rates occurring in summer of 2012. Mean rates of NCP ranged from 1.3 ± 0.2 to 2.9 ± 0.5 mmol O2·m−2·d−1. The mean ratio of NCP/GOP, a measure of how efficiently the ecosystem is recycling its nutrients, ranged from 0.04 to 0.17, similar to ratios observed at lower latitudes. Additionally, a large increase in total photosynthesis that occurred in 2012, a year of historically low sea ice coverage, persisted for many years. Taken together, these data provide one of the most complete characterizations of interannual variations of biological productivity in this climatically important region, can serve as a baseline for future changes in rates of production, and give an intriguing glimpse of how this region of the Arctic may respond to future lack of sea ice.
    Description: We sincerely thank the scientific teams of Fisheries and Oceans Canada's Joint Ocean Ice Studies expedition and Woods Hole Oceanographic Institution's Beaufort Gyre Observing System. The hydrographic, nutrient, and chlorophyll data were collected and made available by the Beaufort Gyre Exploration Program based at the Woods Hole Oceanographic Institution (http://www.whoi.edu/beaufortgyre) in collaboration with researchers from Fisheries and Oceans Canada at the Institute of Ocean Sciences. We thank the captains and crews of the Canadian icebreaker CCGS Louis S. St‐Laurent and Mike Dempsey for sample collection. This paper was improved by the suggestions of Michael DeGrandpre and one anonymous reviewer. We are grateful to Qing Wang at Wellesley College for her assistance with statistics. We thank our funding sources: the National Science Foundation (NSF 1547011, NSF 1302884, NSF 1719280, NSF 1643735) and the support of Fisheries and Oceans Canada. Data presented and discussed in this paper can be found in the Arctic Data Center (http://10.18739/A2W389).
    Description: 2019-10-30
    Keywords: Oxygen ; Argon ; Gross primary production ; Net community production ; Sea ice ; Triple oxygen isotopes
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 3
    facet.materialart.
    Unknown
    Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis (2015)
    BioMed Central
    Details
    Publication Date: 2015-10-22
    Description: Background: DNA methylation is thought to be extensively involved in the pathogenesis of many diseases, including major psychosis. However, most studies focus on DNA methylation alteration at promoters of protein-coding genes, despite the poor correlation between DNA methylation and gene expression. Methods: We analyzed differentially methylated regions and differentially expressed genes in patients with schizophrenia and bipolar disorder and normal subjects. Gene expression and DNA methylation were analyzed with RNA-seq and MeDIP-seq of post-mortem brain tissue (brain region BA9) cohort in five schizophrenia, seven bipolar disorder cases and six controls, respectively. Results: Here, we performed a large-scale integrative analysis using MeDIP-seq, coupled with RNA-seq, on brain samples from major psychotic and normal subjects and observed obvious discrepancy between DNA methylation and gene expression. We found that differentially methylated regions (DMRs) were distributed across different types of genomic elements, especially introns. These intronic DMRs were significantly enriched for diverse regulatory elements, such as enhancers and binding sites of certain transcriptional factors (e.g., Pol3). Notably, we found that parts of intronic DMRs overlapped with some intragenic miRNAs, such as hsa-mir-7-3. These intronic DMR-related miRNAs were found to target many differentially expressed genes. Moreover, functional analysis demonstrated that differential target genes of intronic DMR-related miRNAs were sufficient to capture many important biological processes in major psychosis, such as neurogenesis, suggesting that miRNAs may function as important linkers mediating the relationships between DNA methylation alteration and gene expression changes. Conclusions: Collectively, our study indicated that DNA methylation alteration could induce expression changes indirectly by affecting miRNAs and the exploration of DMR-related miRNAs and their targets enhanced understanding of the molecular mechanisms underlying major psychosis.
    Electronic ISSN: 1755-8794
    Topics: Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Hypermethylation of the GATA binding protein 4 (GATA4) promoter in Chinese pediatric acute myeloid leukemia (2015)
    BioMed Central
    Details
    Publication Date: 2015-10-22
    Description: Background: Acute myeloid leukemia (AML) is the second-most common form of leukemia in children. Aberrant DNA methylation patterns are a characteristic feature of AML. GATA4 has been suggested to be a tumor suppressor gene regulated by promoter hypermethylation in various types of human cancers although the expression and promoter methylation of GATA4 in pediatric AML is still unclear. Methods: Transcriptional expression levels of GATA4 were evaluated by semi-quantitative and real-time PCR. Methylation status was investigated by methylation-specific PCR (MSP) and bisulfate genomic sequencing (BGS). The prognostic significance of GATA4 expression and promoter methylation was assessed in 105 cases of Chinese pediatric acute myeloid leukemia patients with clinical follow-up records. Results: MSP and BGS analysis showed that the GATA4 gene promoter is hypermethylated in AML cells, such as the HL-60 and MV4-11 human myeloid leukemia cell lines. 5-Aza treatment significantly upregulated GATA4 expression in HL-60 and MV4-11 cells. Aberrant methylation of GATA4 was observed in 15.0 % (3/20) of the normal bone marrow control samples compared to 56.2 % (59/105) of the pediatric AML samples. GATA4 transcript levels were significantly decreased in AML patients (33.06 ± 70.94; P = 0.011) compared to normal bone marrow/idiopathic thrombocytopenic purpura controls (116.76 ± 105.39). GATA4 promoter methylation was correlated with patient leukocyte counts (WBC, white blood cells) (P = 0.035) and minimal residual disease MRD (P = 0.031). Kaplan-Meier survival analysis revealed significantly shorter overall survival time in patients with GATA4 promoter methylation (P = 0.014). Conclusions: Epigenetic inactivation of GATA4 by promoter hypermethylation was observed in both AML cell lines and pediatric AML samples; our study implicates GATA4 as a putative tumor suppressor gene in pediatric AML. In addition, our findings imply that GATA4 promoter methylation is correlated with WBC and MRD. Kaplan-Meier survival analysis revealed significantly shorter overall survival in pediatric AML with GATA4 promoter methylation but multivariate analysis shows that it is not an independent factor. However, further research focusing on the mechanism of GATA4 in pediatric leukemia is required.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Synthesis of vibroarthrographic signals in knee osteoarthritis diagnosis training (2016)
    BioMed Central
    Details
    Publication Date: 2016-07-20
    Description: Vibroarthrographic (VAG) signals are used as useful indicators of knee osteoarthritis (OA) status. The objective was to build a template database of knee crepitus sounds. Internships can practice in the templa...
    Electronic ISSN: 1756-0500
    Topics: Biology , Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Cytogenetic relationships among Citrullus species in comparison with some genera of the tribe Benincaseae (Cucurbitaceae) as inferred from rDNA distribution patterns (2016)
    BioMed Central
    Details
    Publication Date: 2016-04-19
    Description: Comparative mapping of 5S and 45S rDNA by fluorescent in situ hybridization (FISH) technique is an excellent tool to determine cytogenetic relationships among closely related species.
    Electronic ISSN: 1471-2148
    Topics: Biology
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Epidemiology and clinical characteristics of hand foot, and mouth disease in a Shenzhen sentinel hospital from 2009 to 2011 (2013)
    BioMed Central
    Details
    Publication Date: 2013-11-15
    Description: Background: We investigated the epidemiological and clinical data of all hand, foot, and mouth disease (HFMD) cases in a sentinel hospital of Shenzhen, China from 2009 to 2011. Methods: HFMD cases diagnosed in our institution were assessed from 2009 to 2011. Both epidemiological and clinical features were analyzed retrospectively. All the fatal cases were reported. Results: A total of 12132 patients were diagnosed with HFMD, of which 2944 (24.3%) were hospitalized. Of the 2944 hospitalized patients, the highest proportion of diagnosed cases were admitted in May and July (989/2944, 33.6%). In 2009 all severe HFMD cases were diagnosed with enterovirus 71 (EV71). In 2010 and 2011, some of the severe HFMD were diagnosed with Coxsackievirus A16 (CA16). Incidence was highest in 0-4-year old children, with males being predominant. There were sporadic cases with HFMD the whole year except in February. All cases were cured in 2009. Six deaths were reported during 2010 and 2011. Conclusions: EV71 can cause severe complications and deaths in our region. HFMD is an important public health problem in Shenzhen in spite of stringent measures taken in preschool centers. A high degree of vigilance should be maintained over the disease situation.
    Electronic ISSN: 1471-2334
    Topics: Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients (2018)
    BioMed Central
    Details
    Publication Date: 2018-03-06
    Description: Chronic hepatitis B (CHB) remains a global health dilemma with high morbidity and mortality. Human males absent on the first (hMOF) (a histone acetyltransferase) is responsible for DNA damage repair, tumorigen...
    Electronic ISSN: 2045-3701
    Topics: Biology
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Performance of urinary neutrophil gelatinase-associated lipocalin, clusterin, and cystatin C in predicting diabetic kidney disease and diabetic microalbuminuria: a consecutive cohort study (2017)
    BioMed Central
    Details
    Publication Date: 2017-07-13
    Description: Tubular biomarkers have been regarded as emerging and promising markers for early diagnosis of diabetic kidney disease (DKD). The study was to determine the diagnostic capabilities of tubular biomarkers (urina...
    Electronic ISSN: 1471-2369
    Topics: Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Practitioners’ perspectives on evaluating treatment outcomes in traditional Chinese medicine (2017)
    BioMed Central
    Details
    Publication Date: 2017-05-20
    Description: There are no generally accepted standards for evaluation of treatment outcomes in traditional Chinese medicine (TCM). Pattern differentiation and individual treatments are recognized as the most distinguishing...
    Electronic ISSN: 1472-6882
    Topics: Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...