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  • 1
    Electronic Resource
    Electronic Resource
    Induction of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the regenerating kidney after lesions by drugs (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 297-306 
    Details
    ISSN: 1432-1912
    Keywords: Folic Acid ; 2,4,5-Triamino-6-styrylpyrimidme ; Pentose Phosphate Pathway ; Enzyme Induction ; Nuclear RNA ; PolsÄure ; 2,4,5-Triamino-6-styrylpyrimidin ; Pentose-Phosphat-Weg ; Fermentinduktion ; Kern-RNS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After lesions of the proximal tubular cells, the administration of folic acid or 2,4,5-triamino-6-styrylpyrimidine increases the activity of both glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase during the regenerative phase. These increases are greater than those seen after temporary ischemia. Actinomycin and cycloheximide inhibit these processes. The triggering of natural regeneration processes by lesions is evidently enhanced by a chemical induction. The different enzymes are not induced equally during regenertion. This may be concluded from the deviating response of the activity of 3-phosphoglyceraldehyde dehydrogenase. The induction of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase demonstratedin vitro also seems to lead to an increased cell metabolismin vivo. After injection of14C-(U)-glucose, the specific activity of the RNA of isolated kidney cell nuclei after the administration of folic acid was 3 to 6 times that of the controls. The blockade of the oxidative part of the pentose phosphate pathway by 6-AN, which limits the biosynthesis of ribose by selective inhibition of 6-phosphogluconate dehydrogenase, reduces the specific activity of the nuclear RNA to 50% in animals treated with folic acid. The accumulation of 6-phosphogluconate in the kidney cells can lead to an inhibition of phosphoglucose isomerase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00999544
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  • 2
    Electronic Resource
    Electronic Resource
    Die Wirkung von Harnstoff auf die Wasserresorption der salzkonzentrierenden Niere unter Gleichgewichtsbedingungen (1974)
    Springer
    Research in experimental medicine 162 (1974), S. 333-339 
    Details
    ISSN: 1433-8580
    Keywords: Kidney ; Concentrating mechanism ; Corticomedullary gradients ; Urea ; Electrolytes ; Niere ; Konzentrierung ; Corticomedulläre Gradienten ; Harnstoff ; Elektrolyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An wachen, eiweißarm ernährten Wistar-Ratten wurde die Wirkung von Harnstoff auf die renale Wasserretention und Elektrolytkonzentrierung unter standardisierten Bedingungen (Trinkwasserentzug, mehrtägige kombinierte hypertone Harnstoff/NaCl-Infusion) untersucht. Die Ergebnisse lassen erkennen, daß Harnstoff aktiv aus den Sammelrohren resorbiert wird und daß Natrium bei Harnstoffzufuhr stärker im Nierenmarkgewebe angereichert wird als bei reiner Elektrolytinfusion. Die bei Harnstoffzufuhr erhöhten medullären Konzentrationen bewirken einen zunehmenden osmotischen Wasserentzug aus den Sammelrohren ins Interstitium. Die Harnvolumina nehmen bei Anstieg der Elektrolytkonzentrationen entsprechend ab. Es wird geschlossen, daß die wasserretinierende Wirkung des Harnstoffs am besten nachgewiesen werden kann, wenn — bei kalkulierter Wasser- und osmotischer Substanzzufuhr — die GFR konstant gehalten wird, weiterhin das Nephron hoch permeabel für Harnstoff ist, also bei maximalen medullären Natriumkonzentrationen und Harnstoff über längere Zeit bei gleichbleibender Konzentration infundiert wird.
    Notes: Summary Subject of the examinations was the special effect of urea to the renal water retention and electrolyte concentrating ability on protein lacking rats under standardized conditions (no drinking, long-term combined hypertonic urea/saline infusions). The results show, that urea is reabsorbed actively out of the collecting ducts and that sodium is better enriched in the renal medulla during simultaneous urea supply than with pure electrolyte infusion. These increased medullary concentrations cause an enlarged osmotic water removal out of the collecting ducts into the interstitium during urea supply so that the urine volumes decrease and the electrolytes are better concentrated in the urine. It is concluded, that the water retaining effect of urea could be proved best when the glomerular filtrates are kept unchanged, furthermore when the nephron is high permeable for urea, that is by maximal medullary sodium concentration, and when urea is infused by longterm supply in constant rations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851704
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    Paper (German National Licenses)
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