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  • 1980-1984  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Use of the Social Behaviour Assessment Schedule (SBAS) in a trial of maintenance antipsychotic therapy in schizophrenic outpatients: Pimozide versus fluphenazine (1983)
    Springer
    Social psychiatry and psychiatric epidemiology 18 (1983), S. 193-199 
    Details
    ISSN: 1433-9285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Depot fluphenazine decanoate and oral pimozide drug treatments were compared in 36 schizophrenic outpatients over one year in a double-blind, placebo-controlled trial, utilising a “double dummy” design. Analysis of Social Behaviour Assessment Schedule (SBAS) data from the pretrial and end-of-study assessments revealed no significant advantage for either of the drug treatments. However, social performance had improved in both groups over the trial period and this was associated with some relief of related “distress” in the patients' relatives and friends. The most prevalent disturbed behaviours in the sample reflected the negative symptoms of schizophrenia and showed no change over the year. These disturbed behaviours were much in evidence and were associated with a relatively high level of distress in the patients' relatives and friends. These findings suggest that the maintenance therapy of schizophrenic patients, with either depot fluphenazine or oral pimozide, by controlling psychotic symptoms and providing a period of illness stability, may allow a natural process of gradual recovery of social functioning to take place.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583530
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Coarse, jerky foot tremor: Tremographic investigation of an objective sign of acute akathisia (1983)
    Springer
    Psychopharmacology 82 (1983), S. 95-101 
    Details
    ISSN: 1432-2072
    Keywords: Antipsychotic drugs ; Neuroleptic side effects ; Akathisia ; Foot tremor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a previous clinical investigation, jerky foot movements were observed in patients with akathisia. Tremographic techniques were empolyed in the present study to characterise this motor activity. Six psychiatric patients with signs and symptoms of akathisia, six control patients matched for antipsychotic drug dose, and five drug-free normal subjects, were selected and assessed for evidence of drug-induced movement disorders. The two patient groups proved to be closely matched on clinical and demographic variables. An accelerometer was used to record finger and toe tremor in all subjects according to a standard procedure. Analysis of the amplitude, frequency and wave-form data collected revealed that the akathisia patients were characterised by the presence of large amplitude, low frequency (less than 4 Hz), rhythmic foot movements. Changes in the severity of akathisia at follow-up were reflected in changes in the amplitude and frequency of this dyskinesia. Possible clinical and pathophysiological implications of the findings are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426389
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    Paper (German National Licenses)
    Fulltext
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