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  • Benoxaprofen  (1)
  • Depressive states in schizophrenic psychoses  (1)
  • 1980-1984  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 275 (1983), S. 318-323 
    ISSN: 1432-069X
    Keywords: Phototoxicity ; Benoxaprofen ; Photohemolysis ; Mouse-tail technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Benoxaprofen (BP), a non-steroidal antiphlogistic drug causing skin and nail photoreactions, has been evaluated for photoactivity using three experimental techniques. In vivo in the mouse, BP was phototoxic in doses of 25 mg/kg in combination with UV-A 54 J. The phototoxic potency could be confirmed in vitro with the Candida albicans test. In vitro, using photohemolysis, BP showed a dose-dependent activity causing 40% hemolysis at a concentration of about 25 μg/ml with UV-a. Also, small UV-B doses caused red cell lysis with a moderate BP concentration. Preirradiation experiments showed that UV-A, but not UV-B, photoproducts could account for some of the activity. The action spectrum of BP photoactivity lies mainly in the UV-A, but may also extend into UV-B. Compared with chlorpromazine in vivo and in vitro, and with doxycycline in vivo, BP showed intermediate phototoxic activity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 230 (1981), S. 275-292 
    ISSN: 1433-8491
    Keywords: Course of schizophrenic psychoses ; Depressive states in schizophrenic psychoses ; Psychopathometrics ; Verlauf schizophrener Psychosen ; Depressive Zustandsbilder bei schizophrenen Psychosen ; Psychopathometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 81 Patienten mit Schizophrenien oder verwandten Psychosen wurden bei Aufnahme, Entlassung und 5–6 Jahre nach Entlassung mit Fremd- und Selbstbeurteilungsskalen zur Psychopathologie untersucht. Die psychopathometrische Analyse macht die während der stationären Behandlung erreichte Besserung der Patienten im Bereich produktiv-psychotischer wie auch depressiv-apathischer Symptomatik deutlich sowie die Wiederverschlechterung bei Katamnese. So hatten z. B. 67% der Patienten bei Aufnahme deutlich paranoide Symptomatik, 14% bei Entlassung, 30% bei Katamnese. Die Konfigurationsfrequenzanalyse über bestimmte Ausprägungsgrade der Syndrome gibt einen differenzierteren Einblick in die Häufigkeiten von Verbesserungen und Verschlechterungen auf Einzelfallebene. Daraus ergibt sich u. a., daß 26% der Patienten bezüglich der paranoiden Symptomatik bei Katamnese eine Verschlechterung aufwiesen. Depressive Symptomatik bei Entlassung erwies sich bei den meisten Patienten als ein Persistieren schon bei Aufnahme vorhandener depressiver Symptomatik. Selbstbeurteilung und Fremdbeurteilung durch den Psychiater führten nicht zu völlig konkordanten Ergebnissen.
    Notes: Summary Eighty-one patients with schizophrenic or similar psychoses were tested three times using different psychopathological scales: at the beginning and at the end of clinical treatment, and 5–6 years after discharge. The psychopathometrical description showed an improvement in productive-psychotic and depressive-apathetic symptoms during clinical treatment and the deterioration at follow-up. For example 67% of the patients suffered from marked paranoid symptoms at admission, only 14% at discharge, but 30% at follow-up. The configuration-frequency-analysis on syndrome-intensities allowed a more differentiated insight into the frequency of improvement and deterioration in particular cases. As to paranoid symptoms for example, 26% of the patients showed deterioration at follow-up. The majority of the depressive states seen on discharge were already in existence on admission. The results of the self-rating and the rating by the psychiatrist were not in complete concordance.
    Type of Medium: Electronic Resource
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