Summary
Benoxaprofen (BP), a non-steroidal antiphlogistic drug causing skin and nail photoreactions, has been evaluated for photoactivity using three experimental techniques. In vivo in the mouse, BP was phototoxic in doses of 25 mg/kg in combination with UV-A 54 J. The phototoxic potency could be confirmed in vitro with the Candida albicans test. In vitro, using photohemolysis, BP showed a dose-dependent activity causing 40% hemolysis at a concentration of about 25 μg/ml with UV-a. Also, small UV-B doses caused red cell lysis with a moderate BP concentration. Preirradiation experiments showed that UV-A, but not UV-B, photoproducts could account for some of the activity. The action spectrum of BP photoactivity lies mainly in the UV-A, but may also extend into UV-B. Compared with chlorpromazine in vivo and in vitro, and with doxycycline in vivo, BP showed intermediate phototoxic activity.
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References
Bjellerup M, Ljunggren B (in manuscript) Photohemolysis and demethylchlortetracycline phototoxicity
Daniels F Jr (1965) A simple microbiological method for demonstrating phototoxic compounds. J Invest Dermatol 44:259–262
Fenton DA, Wilkinson JD, English JS (1981) Photosensitisation to benoxaprofen not due to ultraviolet A alone. Lancet II:1230–1231
Greist MC, Ozols II Ridolfo AS, Muus JC (1982) The phototoxic effects of benoxaprofen and their management and prevention. Eur J Rheum Inflam 5:138–147
Halsey JP, Cardoe N (1982) Benoxaprofen: Side-effect profile in 300 patients. Br Med J 284:1365–1368
Hindson C, Daymond T, Diffey B, Lawlor F (1982) Side effects of benoxaprofen. Br Med J 284:1368–1369
Johnson BE (1974) Cellular mechanisms of chlorpromazine photosensitivity. Proc Roy Soc Med 67:871–872
Kahn G, Fleischaker B (1971) Red blood cell hemolysis by photosensitizing compounds. J Invest Dermatol 56:85–90
Kligman AM, Kaidbey KH (1982) Phototoxicity to benoxaprofen. Eur J Rheum Inflam 5:124–137
Ljunggren B (1977) Phenothiazine phototoxicity: Toxic chlorpromazine photoproducts. J Invest Dermatol 69:383–386
Ljunggren B, Möller H (1976) Phototoxic reaction to chlorpromazine as studied with the quantitative mouse tail technique. Acta Dermatol Venereol (Stockh) 56:373–376
Mikulaschek WM (1980) Long-term safety of benoxaprofen. J Rheumatol [Suppl 6] 7:100–107
Mikulaschek WM (1982) An up-date on long-term efficacy and safety with benoxaprofen. eur J Rheumatol Inflam 5:206–215
Nash JF, Carmichael RH, Ridolfo AS, Spradlin CT (1980) Pharmacokinetic studies of benoxaprofen after therapeutic doses with a review of related pharmacokinetic and metabolic studies. J Rheumatol [Suppl 6] 7:12–19
Wiskemann A (1981) Photosensibilisierung durch Benoxaprofen. Drug Res 31 [1]:730–732
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Ljunggren, B., Bjellerup, M. & Möller, H. Experimental studies on the mechanism of benoxaprofen photoreactions. Arch Dermatol Res 275, 318–323 (1983). https://doi.org/10.1007/BF00417205
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DOI: https://doi.org/10.1007/BF00417205