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  • Organic Chemistry  (5)
  • General Chemistry  (4)
  • Hypertension  (3)
  • DATE/TIME; Glaciers Austria; Pegelstation_Vernagtbach; River discharge; UGS; Unmanned gauge station; Vernagtferner, Ötztaler Alpen, Austria; Vertical standpipe monitoring
  • 1990-1994  (4)
  • 1970-1974  (8)
Document type
Keywords
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Platelet Na+/H+ antiport activity in patients with insulin-dependent diabetes mellitus with and without diabetic nephropathy (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 119-125 
    Details
    ISSN: 1432-1440
    Keywords: Na+/H+ antiport ; Hypertension ; Diabetic nephropathy ; Hereditary factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The incidence of diabetic nephropathy in patients with insulin-dependent diabetes mellitus (IDDM) may depend on factors other than the quality of diabetes control. Hypertension is an additional factor associated with a high degree of renal involvement in IDDM. One abnormality consistantly observed in various tissues of patients with essential hypertension is enhanced activity of the Na+/H+ antiport. In the present study we have therefore studied platelet antiport activity in 41 healthy subjects (control), in 22 patients with untreated essential hypertension (EH), and in 35 normotensive IDDM patients (type 1). Of these patients 17 exhibited signs of diabetic nephropathy (group 1) while 18 had no evidence for renal involvement of IDDM in spite of a duration of IDDM of at least 10 years (group 2). The two IDDM patient groups were undistinguishable with respect to age, body mass index, and arterial blood pressure (group 1, 117.9±2.4/78.4±1.5 mmHg; group 2, 113.9±3.6/76.1±1.8 mmHg). Antiporter activity was determined from the rate of cell volume changes induced by propionic acid. Platelet Na+/H+ exchange activity averaged 23.43±0.43 10−3·s−1 in control subjects and was markedly elevated in EH (28.38±0.62 10−3·s−1 P〈0.01). Antiport activity in group 2 patients without nephropathy averaged 24.54±0.57 10−3·s−1 and was undistinguishable from the control group. However, platelet Na+/H+ antiport activity was significantly stimulated in group 1 patients with nephropathy as compared to group 2(26.95±0.73 10−3. s−1 ; P〈0.025). Our results show that renal involvement in IDDM is associated with enhanced activity of the platelet Na+/H+ antiport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179992
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma lipids and lipoproteins and essential hypertension (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 944-950 
    Details
    ISSN: 1432-1440
    Keywords: Hypertension ; Low density lipoprotein ; Apo B ; Cholesterol ; Very low density lipoprotein ; Triglycerides ; Lipoprotein (a)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In recent years there have been many studies demonstrating a correlation between increased arterial blood pressure and altered lipid profiles, and there has been an especially positive correlation between high cholesterol levels and blood pressure. There are differences between the various reports that are important. In our study the lipid distribution in 105 hypertensive patients with mild or moderate arterial hypertension according to WHO criteria without clinically or ultrasonographically apparent atherosclerosis was compared to the lipid distribution in 65 age-matched healthy persons. On the epidemiological level a significant, positive association was found between LDL serum levels (P ≤ 0.001), Apo B serum levels (P ≤ 0.001), serum triglyceride levels (P ≤ 0.05) and VLDL serum levels (P ≤ 0.01) and arterial hypertension. However, in contrast to recent reports, no significant difference was found between total serum cholesterol levels in normotensives and hypertensives, and there was no difference in HDL serum levels. No evidence could be found for a significant increase in lipoprotein (a) serum levels in hypertensives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577733
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of casual, ambulatory and self-measured blood pressure in a study of nitrendipine vs bisoprolol (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 569-575 
    Details
    ISSN: 1432-1041
    Keywords: Nitrendipine ; Bisoprolol ; Hypertension ; self-measured blood pressure ; diurnal variation ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double-blind, placebo-controlled study the antihypertensive efficacy and tolerability of a single morning dose of either 10 mg bisoprolol (n=26) or 20 mg nitrendipine (n=27) were investigated. Blood pressure was measured by three techniques: (1) Casual blood pressure 24 h after the dose; (2) ambulatory 24-h whole-day monitoring; and (3) self-recorded blood pressure in the morning 24 h after the dose (6–8 a.m.) and in the evening (6–8 p.m.). After 4 weeks of therapy bisoprolol had produced a highly significant reduction in blood pressure as assessed by casual, ambulatory day- and night-time monitoring, and self-measured morning and evening readings. Bisoprolol was significantly more effective than nitrendipine, which did not induce a significant reduction in the ambulatory night-time recordings. Whole-day ambulatory blood pressure profiles showed an antihypertensive effect of bisoprolol throughout the entire 24-h period. 24-h blood pressure curves after nitrendipine demonstrated a markedly shorter duration of action, with no reduction in early morning blood pressure. Adverse effects and tolerability of the two drugs were comparable. The average changes in systolic and diastolic blood pressure after bisoprolol and nitrendipine in 2-h periods of ambulatory monitoring (6–8 a.m. and 6–8 p.m.) and self-measured blood pressure (6–8 a.m. and 6–8 p.m.) showed a good agreement between ambulatory and self-measured blood pressure determinations with no significant difference between the methods. The results show that 24 h antihypertensive efficacy was more pronounced for bisoprolol than for nitrendipine at the doses studied. Further, self-measured blood pressures at home were suitable for accurate estimation of the 12-h and 24-h antihypertensive efficacy of the two drugs. The methodological findings of this study have important implications for further pharmacological trials investigating the duration of action of antihypertensive drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265917
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  • 4
    Electronic Resource
    Electronic Resource
    Chromatographische Trennung und quantitative Bestimmung aller acht Stereoisomeren von α-TocopherolHerrn Dr. Otto Isler zum 80. Geburtstag gewidmet (1990)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 73 (1990), S. 782-789 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Separation and Quantitation of All Eight Stereoisomers of α-Tocopherol by ChromatographyThe results of the analysis of several derivatives of (all-rac)-α-tocopherol by HPLC on a chiral stationary phase and by capillary GC on a achiral stationary phase are reported. Consecutive application of both methods to the ethyl-ether derivative allows the separation and quantification of all eight possible stereoisomers of (all-rac)-α-tocopherol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19900730403
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  • 5
    Electronic Resource
    Electronic Resource
    Statistische Synthese und intraannulare Reaktion eines RotaxansG. S. und W. B. danken der Deutschen Forschungsgemeinschaft und dem Fonds der Chemischen Industrie für die Unterstützung dieser Untersuchungen. Der Badischen Anilin-und Soda-Fabrik AG, der Bayer AG, der Farbwerke Hoechst AG und der Chemische Werke Hüls AG danken sie für Chemikalien. (1973)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 85 (1973), S. 661-662 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19730851507
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  • 6
    Electronic Resource
    Electronic Resource
    Ozonolytischer Abbau eines CatenansG. S. und E. L. danken der Deutschen Forschungsgemeinschaft und dem Fonds der Chemischen Industrie für die Unterstützung dieser Untersuchungen. Der Badische Anilin- und Sodafabrik AG, der Farbenfabriken Bayer AG und der Chemische Werke Hüls AG danken sie für die großzügige Überlassung von Chemikalien. (1972)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 84 (1972), S. 1144-1145 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19720842306
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  • 7
    Electronic Resource
    Electronic Resource
    Synthesen in der Carotinoid-Reihe 23. Mitteilung22. Mitteilung: [1]. Ein Beitrag zur Chromsäure-Oxydation von PolyenenHerrn Professor Dr. H. H. Inhoffen zum 65. Geburtstag gewidmet (1971)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 54 (1971), S. 2447-2459 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chromic acid oxidation of polyenes with terminal β-ionylidene groups has been studied. A number of hitherto unknown and unexpected oxidation products has been isolated. A mechanism for these oxidations is discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19710540808
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  • 8
    Electronic Resource
    Electronic Resource
    Pyrrolidide als Derivate für die Strukturaufklärung aliphatischer und alicyclischer Carbonsäuren mittels Massenspektrometrie (1971)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 54 (1971), S. 1599-1605 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The pyrrolidide group is, in contrast to the carboxy- and ester groups, capable of inducing strong electron impact fragmentation at the b̃- and γ-bonds in complicated alicyclic and aliphatic compounds. The fragments so formed allow certain conclusions concerning the structure in the neighbourhood of the functional group.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19710540611
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  • 9
    Electronic Resource
    Electronic Resource
    Die Struktur von Maytenin (1973)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 56 (1973), S. 474-478 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In den Jahren 1933-37 sind eine Reihe von Arbeiten über die Inhaltsstoffe von Maytenus Chuchuhuasha und über die pharmakologische Wirkung von Chuchuhuasha-Extrakten. publizier worden [1], deren Inhalt sehr eingehend in der Dissertation von Robert Colas zusammengefasst wurde [2].Die verschiedenen Maytenus-Sendungen (hauptsächlich Wurzeln und Stammrinde), die Colas erhielt, stammten aus dem oberen Amazonasgebiet: drei Muster aus Iquitos (Peru) und drei Sendungen aus Leticia (Columbien). Wässerige Extrakte dieser Pflanzen werden von den Eingeborenen jener Gegenden als Aphrodisiakum eingenommen.Die botanische Bestimmung des Pflanzenmaterials wurde damals von dem einen von uns (R. H.) vorgenommen. Anhand von makroskopischen und mikroskopischen Untersuchungen der Stammrinde, der Blätter und Blüten wurde festgestellt, dass es sich bei einer der Sendungen ein wandfrei um eine neue Maytenus-Spezies handelte, die als Maytenus Chuchuhuasha (Raymond Hamet et Colas) bezeichnet und die botanisch auch gegen Maytenus communis abgegrenzt wurde. Weniger sicher war die Bestimmung einer zweiten Maytenus-Spezies, die gelegentlich erhalten wurde. Sie wurde in der Dissertation Colas als «Maytenus non déterminé» bezeichnet und wurde chemisch nicht weiter bearbeitet. Gelegentlich enthielten Pflanzensendungen auch eine neue Salacia-Spezies (Hippocrataceae), die Salacia Colasi (R. Ben.) benannt wurde. Auch diese Salacia wurde chemisch nicht weiter untersucht.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19730560140
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  • 10
    Electronic Resource
    Electronic Resource
    Gezielte Synthese von Catena-Verbindungen, XI1) Bis-diansa-Verbindungen des 5-Amino-benzodioxols als Modelle für die Synthese von [3]-Catenanen (1970)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 740 (1970), S. 18-30 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Directed Synthesis of Catena Compounds, XI1). Bis-diansa Compounds of 5-Amino-benzodioxole as Models for the Synthesis of [3]-CatenanesMethods for the synthesis of [3]-catenanes according to the directed synthesis principle are discussed. In model investigations the α.ω-bis-[3,4-dihydroxy-phenyl]-alkanes 8a-c and 9c are ketalized with 1,21-dichloroheneicosan-11-one to give the ketals 10a-c and 11c. These compounds are nitrated to the dinitro derivatives 12a-c and 13c and reduced to the diamines 14a-c and 15c. The cyclization of these compounds using the high dilution method yields bis-diansa compounds of the types 16 and 17. In the case of diamines 14c and 15c, by-products could be isolated from the cyclization. Based on spectroscopic data and chemical reactions structures 18, 20 and 22 or 18, 21 and 23 (n = 12) are assigned to these compounds. It is discussed how the lengths of the chains connecting the two aromatic nuclei may influence the structure of the cyclization products.
    Notes: Verfahren zur Darstellung eines [3]-Catenans nach dem Prinzip einer gezielten Synthese werden angegeben und Modelluntersuchungen durchgeführt. Ausgehend von den α.-ω-Bis-[3.4-dihydroxy-phenyl]-alkanen 8a-c und 9c werden durch Ketalisierung mit 1.21-Dichlorheneicosanon-(11) die Ketale 10a-c und 11c hergestellt. Über die Dinitro-Derivate 12a-c und 13c werden die Diamine 14a-c und 15c erhalten. Die Cyclisierung dieser Verbindungen unter Verdünnungsbedingungen führt zu Bis-diansa-Verbindungen der Typen 16 und 17. Im Falle der Diamine 14c und 15c lassen sich Nebenprodukte isolieren, für welche aufgrund spektroskopischer Daten und chemischer Umsetzungen die Strukturen 18, 20 und 22 bzw. 18, 21 und 23 (n = 12) angegeben werden. Der Einfluß der Länge der die beiden aromatischen Ringe verbindenden Polymethylen-Kette auf die Struktur der Cyclisierungsprodukte wird diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19707400103
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