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  • 1
    Electronic Resource
    Electronic Resource
    Idiopathic benign biliary stricture (1998)
    Springer
    Journal of hepato-biliary-pancreatic surgery 5 (1998), S. 463-466 
    Details
    ISSN: 1436-0691
    Keywords: Key words: benign biliary stricture ; localized primary sclerosing cholangitis ; extrahepatic bile duct
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A rare case of idiopathic benign biliary stricture is reported. A 50-year-old man with liver dysfunction underwent ultrasonography, which revealed dilation of the intrahepatic bile ducts, and endoscopic retrograde cholangiopancreatography, which revealed a short, ring-like stenosis at the junction of the left and right hepatic ducts. Although a benign stricture was suspected, radiologic tests alone were insufficient to make a firm diagnosis. Therefore, a cholecystectomy and resection of the extrahepatic biliary tract were performed. Microscopic examination of the resected specimen demonstrated no evidence of malignancy. The final diagnosis was mild, localized, chronic cholangitis. The patient had not had previous biliary tract surgery, choledocholithiasis, nor did he have a congenital abnormality of the biliary tract, bile duct carcinoma, or pancreatic disease. Since there was no evidence of primary sclerosing cholangitis, the stricture was considered to be idiopathic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005340050074
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Microwave Coagulonecrotic Therapy for Hepatocellular Carcinoma (1996)
    Springer
    World journal of surgery 20 (1996), S. 1076-1081 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The present study reports on the usefulness of microwave coagulonecrotic therapy (MCT) as a treatment option for hepatocellular carcinoma (HCC) with poor hepatic reserve. From June 1992 to March 1995, MCT using a microwave electrode was employed on 8 patients using laparoscopic control and 19 with the open method, and wedge resection (Hx) was applied to the 23 patients. All patients had HCC with poor hepatic reserve. Radiation output was 100 watts with a mean radiation duration of about 30 minutes. The severity of liver dysfunction and the regional characteristics of the tumor (tumor size, multiplicity, portal invasion, tumor depth) were comparable between the MCT and Hx groups. The operative time was significantly shorter for the MCT group than the Hx group. The mean blood loss was 1570 ml in the Hx group but negligible in the MCT group. There was no operative mortality in the MCT group in contrast to 4.3% (1 of 23) in the Hx group. Complications were observed in 11.1% (3 of 27) and 34.8% (8 of 23), respectively, for the MCT and Hx groups. The postoperative total bilirubin had lower values and the start of diet was earlier in the MCT group than the Hx group. The 3-year crude and disease-free survival rates were 86% and 44%, respectively, for patients who underwent MCT, which were comparable to 75% and 14% for those with Hx. MCT can achieve long-term results equivalent to those obtained by wedge resections, but it is less invasive and technically easier. Therefore it can be an alternative option in place of limited resection for HCC with poor hepatic reserve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002689900163
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Urate transport in nephrons of gouty patients: quantitative analysis of urate transport in nephrons (1999)
    Springer
    Clinical and experimental nephrology 3 (1999), S. 169-174 
    Details
    ISSN: 1437-7799
    Keywords: Key words Urate excretion ; Urate transport in nephrons ; Hyperuricemia ; Pyrazinamide test ; Benzbromarone test ; Four-component theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Urate underexcretion has been reported as the major cause of hyperuricemia in gouty patients. The four-component theory of urate transport in nephrons has been a valuable hypothesis for studying the mechanism of the urate underexcretion, but accurate quantitative analysis of urate transport in nephrons at different sites has not yet been carried out. To determine the amount of urate transport in nephrons more accurately, we applied mathematical calculations to urate transport in nephrons based on the four-component theory. Methods. In 20 gouty patients and 14 normal controls, 60-min urine fractions and blood samples taken at the midpoint of the urine collection period were collected before and after pyradinamide or benzbromarone administration, and urate clearance (Cua) was determined. Urate excretion (Uua) was defined as {Ccr(1-R1) + Cs} Sua(1-R2), where Ccr is creatinine clearance, R1 is the presecretory reabsorption rate, Cs (ml/min) is the secretion rate, Sua is serum urate level, and R2 is the postsecretory reabsorption rate. Results. In the gouty patients, urate glomerular filtration was significantly higher than in the normal controls, but approximately 96% of the filtered urate was reabsorbed. The urate secretion rate of gouty patients was markedly lower than that of the controls, but the amount of urate secretion was slightly and not significantly lower than that of the controls. Postsecretory reabsorption was proportional to intratubular urate concentration. Subsequent urinary excretion in gouty patients was significantly lower than that in the normal controls. Presecretory reabsorption, secretion, postsecretory reabsorption, and urinary excretion comprised 95.9%, 38.9% 38.6%, and 4.4% of urate glomerular filtration in gouty patients, and 96.2%, 52.2%, 49.6%, and 6.5% in normal controls, respectively. Conclusions. Urate secretion in the nephrons of gouty patients was significantly decreased compared with that in normal controls in terms of its rate and its proportion to urate glomerular filtration, which resulted in significant reduction of urinary urate excretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570050030
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    Paper (German National Licenses)
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