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  • 1
    Electronic Resource
    Electronic Resource
    Phenotypic and functional characteristics of intestinal intraepithelial lymphocytes during acute rejection of small intestinal allografts (1998)
    Springer
    Transplant international 11 (1998), S. 102-109 
    Details
    ISSN: 1432-2277
    Keywords: Key words Intestinal transplantation ; acute rejection ; intraepithelial lymphocytes ; Acute rejection ; intraepithelial lymphocytes ; intestinal transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Infiltration of a transplanted organ by host lymphoid cells is the hallmark of acute rejection. However, after intestinal transplantation, physiological lymphocyte migration may lead to host cell infiltration of the graft even in the absence of rejection. It is unclear whether this lymphocyte migration also involves the intraepithelial compartment of the graft or whether infiltration there is indicative of acute rejection. We demonstrate here that host cell infiltration of the intestinal mucosa occurs both during acute rejection of a small bowel allograft and, to a lesser extent, when rejection is prevented by immunosuppression with FK506. The infiltrating host cells consisted of CD3 + T cells with a predominant CD4–CD8 + phenotype resembling intraepithelial lymphocytes (IELs). Functional studies showed that the nonspecific cytolytic activity of IELs was not affected by acute rejection or by immunosuppression with FK506. These findings indicate that host cell infiltration of the intestinal mucosa does not connote an ongoing acute rejection. Furthermore, the decreased mucosal barrier function during acute rejection of intestinal allgrafts is probably not due to impaired cytolytic activity of IELs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050112
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  • 2
    Electronic Resource
    Electronic Resource
    Myoelectric activity and absorptive capacity of rat small intestinal isografts (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 1082-1087 
    Details
    ISSN: 1573-2568
    Keywords: small intestine ; transplantation ; gastrointestinal motility ; intestinal absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3±0.3/hr in controls and 1.8±0.4/hr in transplants (P〈0.05). MMC frequency in the jejunoileum was 5.1±1.3/hr in controls and 3.2±0.9/hr in transplants (P〉0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80±3% of the time in controls and 59±7% of the time in transplant rats (P〈0.05). Absorption in the transplanted jejunoileum demonstrated a 35–40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103±6 cm for controls and 51±3 cm for transplant rats (P〈0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088223
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Decreased mucosal IgA levels in ileum of patients with chronic ulcerative colitis (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 805-811 
    Details
    ISSN: 1573-2568
    Keywords: immunoglobulin A ; ulcerative colitis ; ileum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with chronic ulcerative colitis (CUC) are known to have decreased spontaneous IgA secretion by colonic mononuclear cells. The aim of this study was to determine whether a similar alteration exists in the apparently healthy ileum of patients with CUC. The concentration of IgA was measured in the supernatant from homogenized mucosal ileal biopsies using a sandwich-type ELISA. The concentration of IgA was significantly (P=0.025) decreased in the ileum of patients with CUC (N=24) in comparison to normal ileum (N=10). The number of mucosal IgA-containing mononuclear cells (MNC) was also determined using an avidin-biotin-immunoperoxidase technique on paraffin-embedded ileal sections. Although reduced, the number of positive cells and their distribution was not significantly different in the ileum of patients with CUC (N=20) when compared to normal ileum (N=10). We suggest that decreased mucosal IgA levels are a panintestinal condition in CUC and that this is a primary alteration rather than a secondary response to the inflammatory process. Considering the role of IgA, we propose that decreased mucosal IgA levels in CUC may predispose to the disease by a reduction of the immune-mediated exclusion mechanism and/or by an impairment of the down-regulation of the inflammatory response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064983
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    Paper (German National Licenses)
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