GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Outcome of peripheral blood stem cell mobilization in advanced phases of CML is dependent on the type of chemotherapy applied (1998)
    Springer
    Annals of hematology 77 (1998), S. 21-26 
    Details
    ISSN: 1432-0584
    Keywords: Key words CML ; Chemotherapy ; PBSC mobilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  High-dose chemotherapy with autologous transplantation of in vivo purged PBSC is a novel investigational approach to treating chronic myelogenous leukemia (CML) patients not responsive to conventional therapy with interferon-α (IFN-α) and not eligible for allogeneic transplantation. PBSC mobilization using either '5+2/7+3'-type chemotherapy or 'mini-ICE/ICE' chemotherapy was investigated in 43 patients with advanced phases of Philadelphia (Ph)-positive CML. Thirty patients were in late chronic phase (〉12 months post diagnosis) and 13 patients in accelerated phase (AP) or blast crisis (BC). Contamination with Ph-positive cells was evaluated in harvests from 37/43 patients. The outcome of PBSC mobilization was dependent on the type of chemotherapy administered: a complete or major cytogenetic response (〈35% Ph-positive metaphases) in leukapheresis collections was obtained in ten of 15 patients treated with 'mini-ICE/ICE' but in only three of 28 patients treated with '5+2/7+3' chemotherapy. One patient (1/43) in blast crisis died during mobilization therapy (2%). Twenty-five patients underwent PBSC transplantation and all of them engrafted successfully. Transplantation-related mortality was 0%. The data show that in advanced phases of CML the chance of harvesting Ph-negative peripheral blood stem cells depends on the type of chemotherapy used for mobilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050406
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Nosocomial candidaemias due to species other than Candida albicans in cancer patients (1999)
    Springer
    Supportive care in cancer 7 (1999), S. 428-431 
    Details
    ISSN: 1433-7339
    Keywords: Key words Fungaemia ; Non-albicans Candida spp. ; Cancer patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Forty-five cases of fungaemia due non-albicans Candida spp. (NAC) in a single National Cancer Institution within 10 years were analysed for aetiology, risk factors and outcome. There had been 12 cases of fungaemia that were due to C. krusei, 14 due to C. parapsilosis, 7 due to C. (T.) glabrata, 6 to C. tropicalis, 2 to C. guillermondii, 2 to C. lusitaniae, 1 to C. stellatoidea, and 1 to C. rugosa. Comparison of 45 NAC fungaemia with 75 episodes of C. albicans fungaemia revealed differences only in two risk factors: previous empiric therapy with amphotericin B (16.0 vs 2.2%, P〈0.01) appeared more frequently in cases of C. albicans fungaemia, and prior prophylaxis with fluconazole (8.9 vs 0%, P〈0.02) was conversely more frequently observed with NAC. The incidence of other risk factors, such as underlying disease, chemotherapy, antibiotic prophylaxis or therapy, treatment with corticosteroids, catheter insertion, mucositis, cytotoxic chemotherapy, and neutropenia, was similar in both groups. There was no difference either in attributable or in overall mortality between NAC and C. albicans fungaemia in our cancer patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005200050304
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Gamma-Knife Radiosurgery of Meningiomas—Preliminary Results and Complications (1998)
    Springer
    Journal of radiosurgery 1 (1998), S. 35-42 
    Details
    ISSN: 1573-8752
    Keywords: Meningioma ; γ knife ; postirradiation edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract During 4 years we have treated 202 patients with meningiomas using the Leksell γ knife. The results in 156 patients with a postoperative follow-up of at least 6 months were assessed. Collateral edema after radiosurgery occurred in 16 patients (10.3%), and in 8 patients it was asymptomatic. The collateral postirradiation edema gradually improved in 14 patients. The tumor volume increased in 10 patients. In seven patients, enlargement caused by intratumoral edema was temporary and a subsequent decrease in tumor volume was observed. In three patients there was real growth after radiosurgery; in two cases the meningioma was malignant and in one patient the tumor volume was underestimated for radiosurgery. Shrinkage of the tumor was observed in 59 patients (38%). An improvement in the clinical state was observed in 48 patients (31%). An impairment of neurodeficit was observed in 10 patients (6.4%), in 6 patients after the antiedematic corticotherapy neurodeficit gradually improved. An average dose of 13.5 Gy to the tumor margin was applied. The optimal marginal dose for meningioma seems to be in the range of 12–16 Gy. Radiosurgery is a noninvasive treatment method suitable as an alternative treatment for meningiomas when the immediate decompressive effect of open neurosurgery is not necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:JORA.0000010875.17544.b2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Assessment of the Accuracy of Stereotactic Target Localization Using Magnetic Resonance Imaging: A Phantom Study (1998)
    Springer
    Journal of radiosurgery 1 (1998), S. 99-111 
    Details
    ISSN: 1573-8752
    Keywords: Magnetic resonance ; stereotactic localization ; stereotactic radiosurgery ; geometric distortion in MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Magnetic resonance imaging is a valuable technique for brain target visualization and localization for stereotactically guided open surgery, stereotactic biopsy, or stereotactic radiosurgery. However, questions remain regarding the extent of image distortion (caused mainly by inhomogeneity of the constant magnetic field induced by the imaged object and nonlinearities in the gradient fields) and its effect on the accuracy of stereotactic localization. A phantom study has been carried out to assess the accuracy of stereotactic localization using spin echo T1-weighted, T2-weighted, proton density, and gradient echo three-dimensional magnetic resonance imaging. A special cubical perspex phantom with the insert of an array of 81 solid perspex rods (2 mm in diameter and spaced 15 mm) was constructed and attached to the base of a Leksell sterotactic frame. The deviations between sterotactic coordinates based on magnetic resonance imaging determined in the treatment planning system and real geometrical position given by the construction of an array of perspex rods within the phantom were evaluated in a series of axial and coronal images for the above-mentioned four sequences. No dependence of the extent of deviations on the investigation sequences was observed. The image orientation and spatial position of measured points in the volume of cubical phantom were also not significantly influenced. The maximal deviation was observed for T1-weighted coronal study, 1.8 mm in the Z coordinate. However, average deviations in all of the eight performed studies were less than or equal to 0.6 mm. Phantom measurements proved minimal distortion effects for all investigated modalities and therefore no special corrections were applied for stereotactic localization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:JORA.0000010893.37324.87
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Acoustic Neurinoma and Its Treatment Using the Leksell γ-Knife as a Primary or Secondary Treatment (1999)
    Springer
    Journal of radiosurgery 2 (1999), S. 13-22 
    Details
    ISSN: 1573-8752
    Keywords: Acoustic neurinoma ; radiosurgery ; Leksell γ-knife ; therapy ; results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Over 4 years (1992–1996) we have treated 122 patients with unilateral acoustic neurinoma using the Leksell γ-knife; 121 patients had a follow-up of 2–48 months (median 24 months). Tumor volume was 0.1–17.8 cm3 (median 2.9 cm3); dose to the tumor margin was 10–17.5 Gy (median 12 Gy) delivered on 40–80% isodose (median 50%). A decrease in the tumor volume was observed in 41.3% of patients, the tumor volume was unchanged in 54.6%, and an increase in the tumor despite radio-surgery was observed in 4.1%. Hearing loss was detected in 17.4% of patients, and 3% of patients gained useful hearing after radiosurgery. The overall risk of the method is 4.3% of hearing loss. Weakness of the facial nerve was observed in 1.9% of patients; normalization of the weakness, which was present before radiosurgery, was observed in 6.3% of patients. The overall risk of facial weakness is 1% for γ-knife radiosurgery. Impairment of trigeminal neuropathy was observed in 5% of patients and improvement in 31%. Impairment of vertigo was observed in 5.8% of patients and improvement in 46%. Leksell γ-knife radiosurgery was the primary treatment in 97 patients (80.7%); microsurgical resection preceded radiosurgery in 24 patients (19.8%). Hearing loss and neuropathy of facial and trigeminal nerves before γ-knife radiosurgery were significantly more frequent in the group of patients with previous microsurgical resection than in the group with γ-knife radiosurgery as the primary treatment. After radiosurgery there was no significant difference in impairment or improvement of hearing, facial and trigeminal nerve neuropathy, and vertigo and imbalance for the groups of patients with previous microsurgery or primary γ-knife treatment. After γ-knife radio-surgery neuropathy of facial and trigeminal nerves in the group of patients with previous microsurgery was significantly worse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022904000330
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    P-odd effectiveZγγγ interactions (1995)
    Springer
    The European physical journal 67 (1995), S. 313-319 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A general analysis of the lowest-dimensionalP-oddZγγγ interaction is performed. It turns out that there are only two independent gauge invariant dimension-eight effective Lagrangians of such a type, similarly to theP-even case discussed earlier. It is shown, that such an effective interaction is naturally induced, at the twoloop level, within an extension of the standard model of electroweak interactions involving two-doubletCP-violating Higgs sector.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01571293
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Preparation and properties of Er and Yb doped InP-based semiconductor compounds (1999)
    Springer
    Czechoslovak journal of physics 49 (1999), S. 757-763 
    Details
    ISSN: 1572-9486
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In this paper we pursue the effect of the erbium and ytterium addition during the liquid phase epitaxial (LPE) growth on physical properties of thin InP layers. Series of InP layer samples were prepared by LPE from the melts containing 0–0.3 wt.% of Er and Yb. The grown layers were examined by the Hall effect and C–V measurements, photoluminescence spectroscopy and Rutherford backscattering spectrometry (RBS). We have found that only Yb impurity was incorporated into the lattice of InP layer. With increasing Yb content in the growth melt the layer's conductivity smoothly changed from n to p type when Yb admixture exceeded certain limit. On the basis of these results we prepared p–n junctions in the InP layers directly doped by Yb, and tested then by C–V measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021233006183
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Effect of holmium addition during LPE growth on the properties of InP and GaInAsP layers (1997)
    Springer
    Czechoslovak journal of physics 47 (1997), S. 685-691 
    Details
    ISSN: 1572-9486
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The influence of holmium addition during the liquid phase epitaxial growth (LPE) on the optoelectronic properties of InP and GaInAsP semiconductor layers has been studied. Series of InP and GaInAsP layer samples have been prepared by LPE from the melt containing 0–0.5 wt.% of the Ho. The samples were examined by different diagnostic techniques. Hall effect, capacitance-voltage curves and photoluminescence spectra showed the dramatic impact of the Ho admixture on the carrier and residual donor concentrations. The carrier density was reduced by two-and-a-half orders of magnitude and photoluminescence spectra became markedly narrowed and their fine features were resolved. The observed effects are attributed to holmium acting as a very efficient gettering agent with regard to shallow donors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021226516119
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Anomalous couplings of vector bosons and the decay H → γγ: Dimensional regularization versus momentum cutoff (1999)
    Springer
    Czechoslovak journal of physics 49 (1999), S. 1471-1488 
    Details
    ISSN: 1572-9486
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract As an illustration of general principles, the W-boson loop contribution to the amplitude for the decay H → γγ is calculated within a specific model for the effective lagrangian describing the anomalous gauge boson couplings. Different approaches to the dependence of the result on the scale of new physics Λ are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021162029323
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...