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  • 1
    Electronic Resource
    Electronic Resource
    Experimental comparison of a helium electron polarimeter with a calibrated high-precision Mott detector (1995)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 4885-4893 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Comparative electron polarization measurement with a helium electron polarimeter and a high-precision Mott detector are presented. For these measurements the helium electron polarimeter was calibrated according to theory, whereas the Mott detector was calibrated independently with an improved auxiliary-target method. The comparison of the experimental results reveals various problems inherent in helium electron polarimetry, such as poor efficiency and problems occurring in precise light polarization measurements. At present, a high-precision Mott detector is therefore clearly superior to a helium polarimeter with respect to efficiency and accuracy. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146170
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  • 2
    Electronic Resource
    Electronic Resource
    Angiotensin-Converting Enzyme Inhibition and Ventricular Remodeling After Myocardial Infarction (1995)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 57 (1995), S. 805-826 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.57.030195.004105
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  • 3
    Electronic Resource
    Electronic Resource
    Guidelines for measurement skin colour and erythema A report from the Standardization Group of the European Society of Contact Dermatitis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 35 (1996), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This report reviews individual-related variables (age, sex, race, anatomical site. skin surface properties), intra- and interindividual variation (temporal, physical and mental activity, orthostatic effect, menstrual cycle/menopause), environment-related variables (light conditions, temperature) and various instrument-related variables that influence skin colour. CIE colorimetry (Minolta Chroma Meter) and spectrophotometric measurement (Derma Spectrometer) are considered. The guidelines give recommendations for measuring conditions and procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1996.tb02258.x
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  • 4
    Electronic Resource
    Electronic Resource
    The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins (1999)
    Springer
    Journal of molecular medicine 77 (1999), S. 386-392 
    Details
    ISSN: 1432-1440
    Keywords: Key words Replication factor C ; RFCp140 ; Cell cycle ; G1 phase regulatory proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The DNA-binding subunit of replication factor C (RFCp140) plays an important role in both DNA replication and DNA repair. The mechanisms regulating activation of RFCp140 thereby controlling replication and cellular proliferation are largely unknown. We analyzed protein expression of RFCp140 during cell cycle progression and investigated the association of RFCp140 with cell cycle regulatory proteins in cell lines of various tissue origin and in primary hematopoietic cells. Western and Northern blot analyses of RFCp140 from synchronized cells showed downregulation of RFCp140 when cells enter a G0-like quiescent state and upregulation of RFCp140 in cycling cells. Translocation from the cytoplasmic compartment to the nucleus did not account for the significant increase in RFCp140 protein levels observed in cycling cells. To investigate a potential association of RFCp140 with cell cycle regulatory proteins coimmunoprecipitation assays were performed. These studies demonstrated specific binding of RFCp140 to cdk4-kinase in hematopoietic and fibroblast cell lines. Additional coimmunoprecipitation studies revealed specific association of RFCp140 with cyclin D1, p21, proliferating cell nuclear antigen, and retinoblastoma protein. These findings link DNA replication and repair factor RFCp140 to G1 phase cell cycle regulatory elements critically involved in cell cycle control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050365
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  • 5
    Electronic Resource
    Electronic Resource
    A broad emitter diode laser system for lithium spectroscopy (1998)
    Springer
    Applied physics 67 (1998), S. 163-166 
    Details
    ISSN: 1432-0649
    Keywords: PACS: 42.50.Vk; 32.80.P; 42.60.By
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: 7 Li atoms. With 70 mW of laser power, 107 atoms have been loaded from a nearby thermal source.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003400050488
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  • 6
    Electronic Resource
    Electronic Resource
    Glucocorticosteroids and HELLP syndrome – current status (1999)
    Springer
    Der Gynäkologe 32 (1999), S. 783-790 
    Details
    ISSN: 1433-0393
    Keywords: Key words HELLP syndrome • Preeclampsia • Gucocorticosteroids • Fetal and maternal morbidity and mortality ; Schlüsselwörter HELLP-Syndrom • Präeklampsie • Schwangerschaftsverlängerung • Glukokortikoide • Fetale und maternale Morbidität und Mortalität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das HELLP-Syndrom ist durch eine hohe perinatale und maternale Morbidität und Mortalität gekennzeichnet. Da sich im Regelfall die Symptomatik des HELLP-Syndroms rasch nach der Schwangerschaftsterminierung bessert, hat sich bis heute die frühzeitige Entbindung nach Diagnosestellung durchgesetzt. Nachteil dieses Vorgehens ist die hohe Rate an Frühgeburtlichkeit vor der 32. SSW. Bisher konnten zwölf Untersuchungen bei etwa 330 Schwangerschaften zeigen, daß alternativ auch eine Schwangerschaftsverlängerung – insbesondere bei Schwangerschaften vor der 32. SSW – sinnvoll ist und dadurch eine z. T. erhebliche zusätzliche intrauterine Reifung erzielt werden kann. Erste Untersuchungen geben Hinweise, daß Glukokortikoide einen positiven Effekt auf den Verlauf eines HELLP-Syndroms haben. In 8 der 12 vorliegenden Studien wurden zumindest teilweise Glukokortikoide angewendet, der Benefit von Glukokortikoiden wurde allerdings nicht sicher nachgewiesen, da auch bei Verzicht komplikationslose Schwangerschaftsverlängerungen erreicht werden konnten. Es ist somit weder abschließend geklärt, ob die niedrigen maternalen und perinatalen Komplikationsraten bei HELLP-Patientinnen mit Schwangerschaftsverlängerung auch auf wesentlich größere Fallzahlen reproduzierbar sind, noch ist sicher zu beantworten, inwieweit Glukokortikoide beim HELLP-Syndrom den biochemischen und klinischen Verlauf beeinflussen.
    Notes: Summary HELLP syndrome is characterized by a high incidence of fetal and maternal morbidity and mortality. It is known that the clinical and biochemical course in patients with HELLP syndrome improves spontaneously after prompt termination of pregnancy. The disadvantages of this regimen is the high rate of prematurity before the 32nd gestational week. In contrast to the routine recommendations, 12 studies including 330 patients have demonstrated that pregnancy prolongation in patients with HELLP syndrome may offer certain advantages. There is evidence that glucocorticosteroids may affect the course of HELLP syndrome before and even after the pregnancies are terminated. In 8 out of the 12 studies steroids were at least administered in some of the cases. Nevertheless, only a single randomized and controlled study was performed that demonstrated an effect in patients treated with steroids as compared to non-steroid-treated HELLP patients. Several additional studies have shown that puerperal recovery in patients with antepartum HELLP syndrome is accelerated if steroids are given. In contrast to evidence of the benefit of steroids, another study has demonstrated pregnancy prolongation in HELLP patients without the administration of glucocorticoids. In the future additional extensive studies should define inclusion criteria for pregnancy prolongation in patients with HELLP syndrome. Furthermore, the effect of different existing therapeutic regimes – particularly the effect of steroids – on the course of pregnancies complicated by HELLP syndrome should be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00003184
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  • 7
    Electronic Resource
    Electronic Resource
    Cationic lipide mediated transfer of c-abl and bcr antisense oligonucleotides to immature normal myeloid cells: Uptake, biological effects and modulation of gene expression* (1996)
    Springer
    Annals of hematology 72 (1996), S. 73-79 
    Details
    ISSN: 1432-0584
    Keywords: Key words c-abl ; bcr ; Antisense ; Cationic lipids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Uptake and biochemical and biological effects of antisense oligodeoxynucleotides (ODN) specific for c-abl and bcr genes were studied in normal immature myeloid cells. CD34-positive cells were purified by positive and negative selection and cultured in liquid culture for 7 days. These cells were then incubated with ODNs, either alone or in combination with cationic lipids. The uptake of ODNs was enhanced by the use of cationic lipids. In addition, very low concentrations of ODNs in combination with cationic lipids were capable of specifically inhibiting the expression of the c-abl gene. In contrast, no effects were seen on the expression of bcr. However, despite the effective blocking of c-abl expression, no changes in cellular growth patterns were observed in liquid culture or in a colony-forming assay. We conclude that the use of cationic lipids might enhance the gene-regulatory effects of ODNs by increasing their uptake into normal hematopoietic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00641311
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  • 8
    Electronic Resource
    Electronic Resource
    Cationic lipide mediated transfer of c-abl and bcr antisense oligonucleotides to immature normal myeloid cells: Uptake, biological effects and modulation of gene expression (1996)
    Springer
    Annals of hematology 72 (1996), S. 73-79 
    Details
    ISSN: 1432-0584
    Keywords: c-abl ; bcr ; Antisense ; Cationic lipids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Uptake and biochemical and biological effects of antisense oligodeoxynucleotides (ODN) specific for c-abl and bcr genes were studied in normal immature myeloid cells. CD34-positive cells were purified by positive and negative selection and cultured in liquid culture for 7 days. These cells were then incubated with ODNs, either alone or in combination with cationic lipids. The uptake of ODNs was enhanced by the use of cationic lipids. In addition, very low concentrations of ODNs in combination with cationic lipids were capable of specifically inhibiting the expression of the c-abl gene. In contrast, no effects were seen on the expression of bcr. However, despite the effective blocking of c-abl expression, no changes in cellular growth patterns were observed in liquid culture or in a colony-forming assay. We conclude that the use of cationic lipids might enhance the gene-regulatory effects of ODNs by increasing their uptake into normal hematopoietic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00641311
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  • 9
    Electronic Resource
    Electronic Resource
    Outcome of peripheral blood stem cell mobilization in advanced phases of CML is dependent on the type of chemotherapy applied (1998)
    Springer
    Annals of hematology 77 (1998), S. 21-26 
    Details
    ISSN: 1432-0584
    Keywords: Key words CML ; Chemotherapy ; PBSC mobilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  High-dose chemotherapy with autologous transplantation of in vivo purged PBSC is a novel investigational approach to treating chronic myelogenous leukemia (CML) patients not responsive to conventional therapy with interferon-α (IFN-α) and not eligible for allogeneic transplantation. PBSC mobilization using either '5+2/7+3'-type chemotherapy or 'mini-ICE/ICE' chemotherapy was investigated in 43 patients with advanced phases of Philadelphia (Ph)-positive CML. Thirty patients were in late chronic phase (〉12 months post diagnosis) and 13 patients in accelerated phase (AP) or blast crisis (BC). Contamination with Ph-positive cells was evaluated in harvests from 37/43 patients. The outcome of PBSC mobilization was dependent on the type of chemotherapy administered: a complete or major cytogenetic response (〈35% Ph-positive metaphases) in leukapheresis collections was obtained in ten of 15 patients treated with 'mini-ICE/ICE' but in only three of 28 patients treated with '5+2/7+3' chemotherapy. One patient (1/43) in blast crisis died during mobilization therapy (2%). Twenty-five patients underwent PBSC transplantation and all of them engrafted successfully. Transplantation-related mortality was 0%. The data show that in advanced phases of CML the chance of harvesting Ph-negative peripheral blood stem cells depends on the type of chemotherapy used for mobilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050406
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  • 10
    Electronic Resource
    Electronic Resource
    Determination of trace and platinum-group elements in high ionic-strength volcanic fluids by sector-field inductively coupled plasma mass spectrometry (ICP-MS) (1998)
    Springer
    Fresenius' journal of analytical chemistry 362 (1998), S. 457-464 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The accurate measurement of ultra-trace concentrations of rare metals and platinum group elements in volcanic fluids is complicated by interferences, complex matrices, and preferential element partitioning. We analyzed condensed, high-temperature magmatic fluids collected from Kudryavy volcano (Kurile Islands, Russia) for Be, B, Rb, Sr, Mo, Ru, Rh, Pd, Cd, W, Re, Pt, Pb, Bi, and U using ICP-MS. The samples had three different matrices: 5 mol L–1 sodium hydroxide (NaOH, pH = 11), gas condensates of sulfuric acid (H2SO4, pH = 0), and solid elemental sulfur. Interferences and suppression/enhancement effects were investigated using standards in concentrated NaOH and H2SO4 solutions to determine adequate dilution for sample analyses, which then required very low levels of element detection (〈 1 μg L–1 for most elements). Depending on the field sampling technique of volcanic gas vents, our results show significant differences in concentrations of some trace elements due to the precipitation of solid sulfur during gas condensation and variations in element volatility as a function of temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160051106
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