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  • Articles  (35)
  • Springer  (32)
  • International Union of Crystallography (IUCr)  (2)
  • Blackwell Science  (1)
  • 1995-1999  (35)
  • 1
    Electronic Resource
    Electronic Resource
    Enhancement of wound healing by curcumin in animals (1998)
    Oxford, UK : Blackwell Science
    Wound repair and regeneration 6 (1998), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tissue repair and wound healing are complex processes that involve inflammation, granulation, and remodeling of the tissue. In this study, we evaluated the in vivo effects of curcumin (difeurloylmethane), a natural product obtained from the rhizomes of Curcuma longa on wound healing in rats and guinea pigs. We observed faster wound closure of punch wounds in curcumin-treated animals in comparison with untreated controls. Biopsies of the wound showed reepithelialization of the epidermis and increased migration of various cells including myofibroblasts, fibroblasts, and macrophages in the wound bed. Multiple areas within the dermis showed extensive neovascularization, and Masson's Trichrome staining showed greater collagen deposition in curcumin-treated wounds. Immunohistochemical localization of transforming growth factor-β1 showed an increase in curcumin-treated wounds as compared with untreated wounds. In situ hybridization and polymerase chain reaction analysis also showed an increase in the mRNA transcripts of transforming growth factor-β1 and fibronectin in curcumin-treated wounds. Because transforming growth factor-β1 is known to enhance wound healing, it may be possible that transforming growth factor-β1 plays an important role in the enhancement of wound healing by curcumin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-475X.1998.60211.x
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  • 2
    Electronic Resource
    Electronic Resource
    2-Methylperimidinium Acetate Monohydrate (1997)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 130-132 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270196012589
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  • 3
    Electronic Resource
    Electronic Resource
    Low-Temperature Structure of Two Copper-Based Precursors for MOCVD: Aquabis(tert-butyl acetoacetato)copper(II) and Bis(dipivaloylmethanido)copper(II) (1996)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 891-894 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270195012157
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  • 4
    Electronic Resource
    Electronic Resource
    Nitrification of ammonium in different components of a flooded rice soil system (1996)
    Springer
    Biology and fertility of soils 23 (1996), S. 321-326 
    Details
    ISSN: 1432-0789
    Keywords: Nitrification ; Flooded rice soils ; Rhizosphere ; Rice variety ; Crop growth stage ; Organic amendment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Nitrification associated with the various components [subsurface soil from unplanted and planted (rhizosphere) fields, standing water and surface soil from planted and unplanted fields and leaf sheath suspensions] of submerged rice paddies was examined in incubation experiments with solutions inoculated with soil or water samples. Substantial nitrification occurred in all samples, standing water and surface soil samples in particular, during their 40-day incubation with NH 4 + −N. Almost all the NH 4 + −N, disappeared during incubation with standing water, was recovered as NO inf3 sup- −N. This, compared to 70–80% from all soil samples and only 29% from leaf sheath suspensions. Significant loss of nitrogen, especially from leaf sheath suspensions, is probably due to nitrification-denitrification as evidenced by its complete recovery in the presence of N-Serve. Nitrification potential of the soil and water samples varied with the crop growth stage and was more pronounced at tillering and panicle inititation stages than at other stages. Nitrification potential of samples from green-manure-amended plots was distinctly less than that of samples from control and urea-amended plots. Most probable number (MPN) estimates of ammonium-oxidizing bacteria were always higher in surface soil in both planted and unplanted plots at all stages of crop growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335961
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  • 5
    Electronic Resource
    Electronic Resource
    Incomplete mixing in large bioreactors — a study of its role in the fermentative production of streptokinase (1996)
    Springer
    Bioprocess and biosystems engineering 14 (1996), S. 91-96 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The production of streptokinase in a batch fermentation has been analysed for the role of incomplete macromixing of the broth. The analysis is based on a kinetic model exhibiting inhibition by the substrate and a primary metabolite (lactic acid), and a mixing model comprising two continuous flow reactors (CFRs) with closed-loop recycle. The inoculum is introduced into one region (one CFR) and the mixing process determines its distribution, growth and reactivity. By varying the dilution rates of the CFRs, any degree of macromixing can be simulated. For dilution rates larger than 1.0 h−1 almost complete macromixing is achieved, for which an analogy has been drawn with micromixing. Increasing the volume of the inoculated region relative to the noninoculated region improves the maximum attainable activity of streptokinase and shortens the time for this. In such a situation an imperfectly mixed bioreactor is superior to a perfectly mixed one, implying that good productivity requires a large inoculated region and incomplete macromixing. These inferences are supported by earlier studies of fluid mixing and relaxation times in bioreactors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387962
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  • 6
    Electronic Resource
    Electronic Resource
    Start-up sensitivity to the initial state of a batch bioreactor for a recombinant Escherichia coli in a complex medium (1996)
    Springer
    Bioprocess and biosystems engineering 15 (1996), S. 215-219 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The sensitivities with respect to the initial state of five key variables describing the performance of a batch bioreactor have been computed from an experimentally validated kinetic model. The system has a recombinant Escherichia coli strain containing the plasmid pBR Eco gap, which codes for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in a complex medium. Since previous studies have shown the start-up sensitivities to be particularly important, the initial 10% of the duration of fermentation was chosen as the time span. The sensitivities of the cell mass, GAPDH and acetate increased with time while those of glucose and yeast extract remained practically constant. Acetate has a crucial role as it functions as both a product and a reactant. With no acetate in the inoculum, the sensitivities of acetate increased an order of magnitude faster than other sensitivities. However, upon addition of acetate through the inoculum, its sensitivities decreased the fastest and stabilised beyond a starting concentration of about 1 g/l whereas other sensitivities stabilised after 5 to 6 g/l of initial acetate. A three-dimensional envelope in the space of acetate concentration-time-relative sensitivity shows a locus of concentrations for minimum time-dependent acetate sensitivity; this may be maintained through fed-batch operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369485
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  • 7
    Electronic Resource
    Electronic Resource
    Nitrification of ammonium in different components of a flooded rice soil system (1996)
    Springer
    Biology and fertility of soils 23 (1996), S. 321-326 
    Details
    ISSN: 1432-0789
    Keywords: Key words Nitrification ; Flooded rice soils ; Rhizosphere ; Rice variety ; Crop growth stage ; Organic amendment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Nitrification associated with the various components [subsurface soil from unplanted and planted (rhizosphere) fields, standing water and surface soil from planted and unplanted fields and leaf sheath suspensions] of submerged rice paddies was examined in incubation experiments with solutions inoculated with soil or water samples. Substantial nitrification occurred in all samples, standing water and surface soil samples in particular, during their 40-day incubation with NH4 +-N. Almost all the NH4 +-N, disappeared during incubation with standing water, was recovered as NO3 –-N. This, compared to 70–80% from all soil samples and only 29% from leaf sheath suspensions. Significant loss of nitrogen, especially from leaf sheath suspensions, is probably due to nitrification-denitrification as evidenced by its complete recovery in the presence of N-Serve. Nitrification potential of the soil and water samples varied with the crop growth stage and was more pronounced at tillering and panicle inititation stages than at other stages. Nitrification potential of samples from green-manure-amended plots was distinctly less than that of samples from control and urea-amended plots. Most probable number (MPN) estimates of ammonium-oxidizing bacteria were always higher in surface soil in both planted and unplanted plots at all stages of crop growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335961
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  • 8
    Electronic Resource
    Electronic Resource
    Analysis of bifurcations in continuous fermentation using recombinant microorganisms with delayed responses (1995)
    Springer
    Bioprocess and biosystems engineering 12 (1995), S. 199-203 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract When the feed rate to a fermenter is varied periodically in order to favor the growth of plasmid-containing cells, a transition may occur from the starting stationary state to another state. The resulting state may be constant or oscillatory. A generalised model based on the adaption times of plasmid-free and plasmid-harboring cells has been used. Analytical conditions have been derived for bifurcation from one nonoscillatory state to another or to an oscillatory state (Hopf bifurcation). The frequency of oscillation is shown to have an upper bound, which can be controlled by manipulating certain process parameters. The production of tryptophan synthetase by the plasmid pPLc23trpAl in E. coli is used as an example to determine the nature of the Hopf bifurcations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01767467
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  • 9
    Electronic Resource
    Electronic Resource
    A heuristic approach to fed-batch optimisation of streptokinase fermentation (1995)
    Springer
    Bioprocess and biosystems engineering 13 (1995), S. 109-112 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Previous studies have shown that the rate of formation of streptokinase, a secondary metabolite, in batch fermentation is proportional to the specific growth rate of the biomass, which in turn is inhibited by its substrate and the primary product (lactic acid). These kinetics suggest the suitability of fed-batch operation to increase the yield of streptokinase. A near-optimal feed policy has been calculated by the chemotaxis algorithm, and it shows a substrate feed rate decreasing nonlinearly and vanishing after 11 hours. This is followed by batch fermentation for a further 8 hours, at the end of which 12% more streptokinase is generated than by purely batch fermentation. Further improvements in productivity are possible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00420437
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  • 10
    Electronic Resource
    Electronic Resource
    DC Electrical Resistivity Study of Granularity in YBa2CU3O7/Ag Composites (1998)
    Springer
    Journal of superconductivity 11 (1998), S. 641-648 
    Details
    ISSN: 1572-9605
    Keywords: Superconductivity ; Ag composites ; percolation ; granularity ; weak-link resistivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract Temperature-dependent electrical resistivity in a set of YBa2Cu3O7−x /Ag composites, all prepared under an identical sintering schedule, is analyzed to extract granularity information. The weak-link resistivity ρ wl across the grain boundaries and the percolation factor α arising due to current frustration caused by misalignment of anisotropic grains and sample defects such as voids and cracks are estimated from the residual resistivity ρ0 and the temperature coefficient of resistivity dρ/dT. Variation of these parameters with Ag vol.% quantifying the extent of granularity indicates that granularity in the composites decreases and their electrical characteristics tend to be identical to that of Ag-free YBa2Cu3O7−x single crystals and epitaxial thin films as Ag vol.% approaches a value where onset of current percolation occurs through Ag channels. The increased α and decreased ρ wl observed at higher Ag vol.% explains the larger grains in the composites with narrow size distribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022609432697
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