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  • Springer  (127)
  • MDPI Publishing
  • Nature Publishing Group (NPG)
  • 1995-1999  (81)
  • 1985-1989  (43)
  • 1930-1934  (3)
Document type
Keywords
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Primary aldosteronism by carcinoma of the adrenal cortex (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 428-432 
    Details
    ISSN: 1432-1440
    Keywords: Rare cause of primary aldosteronism ; Hypokalemic hypertension ; Diagnostic procedure ; Treatment of malignant adrenal disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 58-year-old white woman with hypertension and severe hypokalemia was found to have a carcinoma of the left adrenal gland. Plasma renin activity was constantly under the normal limit, while plasma aldosterone levels were pathologically elevated. Plasma cortisol (8:00 a.m.) and excretion rates of urinary free cortisol were within the normal range. After an adrenalectomy, relapsing excessive aldosterone secretion was successfully treated with opDDD (Lysodrene). Ten months after the diagnosis was established, the patient died from a bleeding liver metastasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715766
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  • 2
    Electronic Resource
    Electronic Resource
    Minoxidil and captopril in severe hypertension (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 327-332 
    Details
    ISSN: 1432-1440
    Keywords: Severe hypertension ; Minoxidil ; Captopril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antihypertensive efficacy of minoxidil and captopril was compared in 23 males with essential or renal parenchymatous hypertension refractory to conventional antihypertensive drug therapy. Following a pretreatment period the patients were randomly assigned to receive either minoxidil, 2.5 mg twice daily (n=12), or captopril, 25 mg twice daily (n=11). In patients with diastolic blood pressure 〉95 mmHg, doses of minoxidil and captopril were increased in 2-week intervals. Patients who maintained diastolic pressure 〉95 mmHg and/or those with intolerable side effects were switched over to the alternative substance. After a mean observation period of 12 weeks a significant decrease in systolic and diastolic blood pressure was observed (179/114 vs 148/92 mmHg in the minoxidil group; 176/111 vs 158/97 mmHg in the captopril group). The primary response rate was 75% in patients treated with minoxidil and 55% in those with captopril (not significant). After the change to the alternative substance two of the four non-responders on captopril and one of the two non-responders on minoxidil became responders. Side effects occurred significantly more often during minoxidil than captopril (p〈0.05). The high efficacy of minoxidil and captopril in the treatment of severe hypertension refractory to conventional drugs was confirmed. Minoxidil lowered blood pressure slightly more than captopril, but it had a higher incidence of side effects than captopril.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711952
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  • 3
    Electronic Resource
    Electronic Resource
    Captopril before and after spironolactone therapy in primary aldosteronism (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 361-363 
    Details
    ISSN: 1432-1440
    Keywords: Primary aldosteronism ; Captopril ; Spironolactone ; Renin-angiotensin ; Converting-enzyme ; Secondary hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In three patients with primary aldosteronism, the acute effect of a single dose of captopril on the elevated mean arterial blood pressure (MAP) was studied before and after 4 weeks of treatment with spironolactone. Before spironolactone therapy, captopril did not cause any drop in MAP. Four weeks later, after an oral daily dose of 400 mg spironolactone, MAP was still elevated in all three patients, though electrolyte abnormalities were fully corrected. Since plasma renin activity (PRA) was increased to values above the normal range, the acute effect of captopril on MAP was tested again. A single dose of 25 mg captopril then caused a fall in MAP to normal. These data reveal the conversion from a renin-independent to a renindependent kind of hypertension after spironolactone therapy in three patients with primary aldosteronism syndrome. This might be of pathogenetic and therapeutic interest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731655
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  • 4
    Electronic Resource
    Electronic Resource
    Atenolol versus pindolol: Side-effects in hypertension (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 89-91 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; pindolol ; sleep disturbance ; β-blockers ; dreaming ; fatigue ; hypertension ; lipophilicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary This randomized crossover out-patient study was designed to compare the antihypertensive effects of atenolol and pindolol. After a wash-out period of two weeks in pretreated cases, 107 patients with essential hypertension were given either atenolol 100 mg once-daily or pindolol 20 mg slow release (SR) once-daily. Both atenolol and pindolol lowered blood pressure over the 24 week period. The diastolic blood pressure reduction was significantly greater (p〈0.01) with atenolol than with pindolol. Before β-blocker therapy, many patients had already experienced side-effects such as fatigue, sleep disturbances and dreams. This probably relates to the high sensitivity of the analogue scale used to assess side-effects, and to the high incidence of such symptoms in untreated patients. As the study progressed there was a reduction in the frequency of fatigue (p〈0.03) and dreams (p〈0.05) in both groups, whereas sleep disturbances significantly increased under pindolol (p〈0.05) but decreased under atenolol (p〈0.05). The only important side-effect difference between the two β-blockers was the higher incidence of sleep disturbances with pindolol which may be due to the higher lipophilicity of this β-blocker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543717
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  • 5
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1996)
    Springer
    Helgoland marine research 50 (1996), S. 539-549 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02367166
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  • 6
    Electronic Resource
    Electronic Resource
    Chemische Zusammensetzung von Samen und Samenschale der Ackerbohne (Vicia faba L.) (1995)
    Springer
    European food research and technology 200 (1995), S. 229-232 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Description / Table of Contents: Zusammenfassung Verschiedene chemische Bestandteile des Samens und der Samenschale der Ackerbohne (Vicia faba L.) wurden untersucht. Die Samen enthalten einen relativ hohen Roheiweiß- (27,5%), niedrigen Rohfett(3,36%) und Ligningehalt (2,65%). Die Samenschale hat eine hohe Faserkonzentration und ist eine bedeutende Ca-Quelle (1,86 g/kg TM). Die höchsten Makroelementkonzentrationen wurden aus Kalium, Phosphor und Magnesium registriert. Die Hauptmikroelemente (Fe, Mn, Cu, Zn) kommen in bedeutend höheren Konzentrationen in den Samen als in der Samenschale vor. Die Aminosäurezusammensetzung der Samen ist positiv (verglichen zu weißer Lupine), das Verhältnis der essentiellen Aminosäuren ist gut. Die Konzentrationen der untersuchten antinutritiven Stoffe, besonders der Alkaloide, sind niedrig. Auf Grund der angeführten chemischen Untersuchungen ist diese Pflanze eine der wertvollsten Hülsenfrüchte; der Anbau und die Verwendung der Samen scheint zukunftsreich zu sein.
    Notes: Abstract Different chemical components were analysed in the seeds and in testa ofVicia faba. The seeds contain a relativ high crude protein (27,5%), a low crude fatt (3,36%) content; and the lignin concentration is low (2,65%). The testa of the seeds has a very high fibre concentration and is a significant Ca-source (1,86 g/kg). The higher macroelement concentrations in the seeds were measured from K, P and Mg. The main microelements (Fe, Mn, Cu, Zn) have significant higher concentrations in the seed than in the testa. The amino acid composition of seeds is positiv (compared to data of white lupine), the rate of essentiell amino acids is good. The concentrations of the examined antinutritiv organic constituents, especially of alkaloids, are low. On the basis of chemical analysis, the production and utilisation of seeds ofVicia faba is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01190501
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  • 7
    Electronic Resource
    Electronic Resource
    Alarm pheromone perception in honey bees is decreased by smoke (Hymenoptera: Apidae) (1995)
    Springer
    Journal of insect behavior 8 (1995), S. 11-18 
    Details
    ISSN: 1572-8889
    Keywords: honey bee ; Apis mellifera ; alarm pheromone ; electroantennograph
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The application of smoke to honey bee(Apis mellifera) antennae reduced the subsequent electroantennograph response of the antennae to honey bee alarm pheromones, isopentyl acetate, and 2-heptanone. This effect was reversible, and the responsiveness of antennae gradually returned to that of controls within 10–20 min. A similar effect occurred with a floral odor, phenylacetaldehyde, suggesting that smoke interferes with olfaction generally, rather than specifically with honey bee alarm pheromones. A reduction in peripheral sensitivity appears to be one component of the mechanism by which smoke reduces nest defense behavior of honey bees.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990966
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  • 8
    Electronic Resource
    Electronic Resource
    Spectroscopy of 200Hg after incomplete fusion reaction (1999)
    Springer
    The European physical journal 6 (1999), S. 141-147 
    Details
    ISSN: 1434-601X
    Keywords: PACS: 21.10.-k Properties of nuclei; nuclear energy levels – 23.20.Lv Gamma transitions and level energies – 23.20.En Angular distribution and correlation measurements – 25.70.Jj Fusion and fusion-fission reactions – 27.80.+w 190 ≤ A ≤ 219
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: High–spin states in 200Hg have been investigated by in–beam γ–ray spectroscopy following the reaction 198Pt(9Be,α3n). The α–emission channel leading to 200Hg is strongly enhanced which may be explained by an incomplete fusion reaction with pre–equilibrium emission of the α particle. The level scheme is extended to higher spins and new band crossings are observed. The band structures are compared to the lighter Hg isotopes with even mass number.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100500050328
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  • 9
    Electronic Resource
    Electronic Resource
    Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin (1987)
    Springer
    Journal of neural transmission 70 (1987), S. 383-398 
    Details
    ISSN: 1435-1463
    Keywords: diazepam ; N-desmethyldiazepam ; endogenous benzodiazepine receptor ligand
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Benzodiazepine-binding inhibitory (BBI) activity was detected in aqueous extracts of brain and peripheral tissues of rats. The BBI activity in brain and in adrenals was, at least partially, due to the presence of N-des-methyldiazepam and diazepam as shown by HPLC, UV-spectroscopy and mass spectrometry. In addition, BBI activity was found in standardized rat food, as well as in a variety of cereals and in other nutritive plant products. In wheat grains diazepam and N-desmethyldiazepam could be identified by HPLC and analysis by gas chromatography combined with mass spectrometry. The estimated amounts of the two benzodiazepines present in rat brain and adrenals and in wheat grains were in the low ppb range. Since laboratory contamination was rigorously excluded we conclude that diazepam and N-desmethyldiazepam are naturally occurring compounds. These findings may explain their occurrence in the brain and adrenals of animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01253613
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  • 10
    Electronic Resource
    Electronic Resource
    In vivo effects of anticonvulsant drugs on nerve terminal (synaptosomal) GABA levels in 11 brain regions of the rat (1985)
    Springer
    Journal of neural transmission 63 (1985), S. 157-167 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thein vivo effects of two GABA-elevating drugs with anticonvulsant properties, namely valproic acid (VPA) and aminooxyacetic acid (AOAA), on nerve terminal GABA levels in discrete rat brain regions were studied by means of a newly developed synaptosomal model. The profile of synaptosomal GABA increases obtained with AOAA was quite different from that seen with VPA. Thus, AOAA (30 mg/kg i.p., 2 hours) caused significant increases in olfactory bulb, cortex, hippocampus, thalamus and cerebellum, whereas VPA (200 mg/kg i.p., 0.5 hour) significantly increased GABA also in hypothalamus, substantia nigra and superior and inferior colliculus. In contrast to the regional selectivity of both drugs with respect to synaptosomal GABA levels, AOAA in most regions was more potent than VPA in increasing whole tissue GABA levels determined prior to subcellular fractionation. The data thus demonstrate that comparison of GABA levels in synaptosomal fractions rather than homogenates from discrete brain areas provides a more sensitive index of the action of GABA-elevating drugs administeredin vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01252615
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