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  • Springer  (57)
  • 2000-2004  (14)
  • 1985-1989  (43)
Publikationsart
Erscheinungszeitraum
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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 65 (1987), S. 428-432 
    ISSN: 1432-1440
    Schlagwort(e): Rare cause of primary aldosteronism ; Hypokalemic hypertension ; Diagnostic procedure ; Treatment of malignant adrenal disease
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A 58-year-old white woman with hypertension and severe hypokalemia was found to have a carcinoma of the left adrenal gland. Plasma renin activity was constantly under the normal limit, while plasma aldosterone levels were pathologically elevated. Plasma cortisol (8:00 a.m.) and excretion rates of urinary free cortisol were within the normal range. After an adrenalectomy, relapsing excessive aldosterone secretion was successfully treated with opDDD (Lysodrene). Ten months after the diagnosis was established, the patient died from a bleeding liver metastasis.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 64 (1986), S. 327-332 
    ISSN: 1432-1440
    Schlagwort(e): Severe hypertension ; Minoxidil ; Captopril
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The antihypertensive efficacy of minoxidil and captopril was compared in 23 males with essential or renal parenchymatous hypertension refractory to conventional antihypertensive drug therapy. Following a pretreatment period the patients were randomly assigned to receive either minoxidil, 2.5 mg twice daily (n=12), or captopril, 25 mg twice daily (n=11). In patients with diastolic blood pressure 〉95 mmHg, doses of minoxidil and captopril were increased in 2-week intervals. Patients who maintained diastolic pressure 〉95 mmHg and/or those with intolerable side effects were switched over to the alternative substance. After a mean observation period of 12 weeks a significant decrease in systolic and diastolic blood pressure was observed (179/114 vs 148/92 mmHg in the minoxidil group; 176/111 vs 158/97 mmHg in the captopril group). The primary response rate was 75% in patients treated with minoxidil and 55% in those with captopril (not significant). After the change to the alternative substance two of the four non-responders on captopril and one of the two non-responders on minoxidil became responders. Side effects occurred significantly more often during minoxidil than captopril (p〈0.05). The high efficacy of minoxidil and captopril in the treatment of severe hypertension refractory to conventional drugs was confirmed. Minoxidil lowered blood pressure slightly more than captopril, but it had a higher incidence of side effects than captopril.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 63 (1985), S. 361-363 
    ISSN: 1432-1440
    Schlagwort(e): Primary aldosteronism ; Captopril ; Spironolactone ; Renin-angiotensin ; Converting-enzyme ; Secondary hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In three patients with primary aldosteronism, the acute effect of a single dose of captopril on the elevated mean arterial blood pressure (MAP) was studied before and after 4 weeks of treatment with spironolactone. Before spironolactone therapy, captopril did not cause any drop in MAP. Four weeks later, after an oral daily dose of 400 mg spironolactone, MAP was still elevated in all three patients, though electrolyte abnormalities were fully corrected. Since plasma renin activity (PRA) was increased to values above the normal range, the acute effect of captopril on MAP was tested again. A single dose of 25 mg captopril then caused a fall in MAP to normal. These data reveal the conversion from a renin-independent to a renindependent kind of hypertension after spironolactone therapy in three patients with primary aldosteronism syndrome. This might be of pathogenetic and therapeutic interest.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 28 (1985), S. 89-91 
    ISSN: 1432-1041
    Schlagwort(e): atenolol ; pindolol ; sleep disturbance ; β-blockers ; dreaming ; fatigue ; hypertension ; lipophilicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary This randomized crossover out-patient study was designed to compare the antihypertensive effects of atenolol and pindolol. After a wash-out period of two weeks in pretreated cases, 107 patients with essential hypertension were given either atenolol 100 mg once-daily or pindolol 20 mg slow release (SR) once-daily. Both atenolol and pindolol lowered blood pressure over the 24 week period. The diastolic blood pressure reduction was significantly greater (p〈0.01) with atenolol than with pindolol. Before β-blocker therapy, many patients had already experienced side-effects such as fatigue, sleep disturbances and dreams. This probably relates to the high sensitivity of the analogue scale used to assess side-effects, and to the high incidence of such symptoms in untreated patients. As the study progressed there was a reduction in the frequency of fatigue (p〈0.03) and dreams (p〈0.05) in both groups, whereas sleep disturbances significantly increased under pindolol (p〈0.05) but decreased under atenolol (p〈0.05). The only important side-effect difference between the two β-blockers was the higher incidence of sleep disturbances with pindolol which may be due to the higher lipophilicity of this β-blocker.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    European food research and technology 211 (2000), S. 346-348 
    ISSN: 1438-2385
    Schlagwort(e): Key wordsCraterellus ; Gomphidius ; Higher fungi ; Hydnum ; Hygrophorus, Laccaria ; Trypsin inhibitors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Laccaria and Hygrophorus species, Craterellus cornucopioides, Gomphidius glutinosus, Macrolepiota rhacodes and Hydnum repandum. The inhibiting activities found were higher than those of cereals but lower than those of some fabaceous plants.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Journal of neural transmission 70 (1987), S. 383-398 
    ISSN: 1435-1463
    Schlagwort(e): diazepam ; N-desmethyldiazepam ; endogenous benzodiazepine receptor ligand
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Benzodiazepine-binding inhibitory (BBI) activity was detected in aqueous extracts of brain and peripheral tissues of rats. The BBI activity in brain and in adrenals was, at least partially, due to the presence of N-des-methyldiazepam and diazepam as shown by HPLC, UV-spectroscopy and mass spectrometry. In addition, BBI activity was found in standardized rat food, as well as in a variety of cereals and in other nutritive plant products. In wheat grains diazepam and N-desmethyldiazepam could be identified by HPLC and analysis by gas chromatography combined with mass spectrometry. The estimated amounts of the two benzodiazepines present in rat brain and adrenals and in wheat grains were in the low ppb range. Since laboratory contamination was rigorously excluded we conclude that diazepam and N-desmethyldiazepam are naturally occurring compounds. These findings may explain their occurrence in the brain and adrenals of animals.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    ISSN: 1435-1463
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Thein vivo effects of two GABA-elevating drugs with anticonvulsant properties, namely valproic acid (VPA) and aminooxyacetic acid (AOAA), on nerve terminal GABA levels in discrete rat brain regions were studied by means of a newly developed synaptosomal model. The profile of synaptosomal GABA increases obtained with AOAA was quite different from that seen with VPA. Thus, AOAA (30 mg/kg i.p., 2 hours) caused significant increases in olfactory bulb, cortex, hippocampus, thalamus and cerebellum, whereas VPA (200 mg/kg i.p., 0.5 hour) significantly increased GABA also in hypothalamus, substantia nigra and superior and inferior colliculus. In contrast to the regional selectivity of both drugs with respect to synaptosomal GABA levels, AOAA in most regions was more potent than VPA in increasing whole tissue GABA levels determined prior to subcellular fractionation. The data thus demonstrate that comparison of GABA levels in synaptosomal fractions rather than homogenates from discrete brain areas provides a more sensitive index of the action of GABA-elevating drugs administeredin vivo.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    European food research and technology 189 (1989), S. 346-350 
    ISSN: 1438-2385
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die vergleichende Untersuchung der chemischen Zusammensetzung von Champignon-(Agaricus) und Austernseitling- (Pleurotus) Arten bzw. von ihren gezüchteten Sorten erfolgte hinsichtlich 23 mineralischer Elemente. Aufgrund des Vergleiches der erzielten Ergebnisse konnte festgestellt werden: DieAgaricus-Arten erwiesen sich mit Ausnahme des gezüchteten Champignons als bedeutende Arsenakkumulatoren, worüber das Schrifttum kaum etwas berichtet, während dies bei denPleurotus-Arten kaum vorkommt. Eine bedeutende Bioakkumulation zeigte die GattungAgaricus hinsichtlich des Cadmiums, mit Ausnahme der ArtenA. xanthoderma undA. bisporus. Eine beachtenswerte Kupferakkumulationsfähigkeit konnte beiAgaricus-Arten (25–260 mg/kg) gegenüber dem Mittelwert von 12,6 mg/kg beiPleurotus festgestellt werden. Die Champignons sind durch einen höheren Kalium- und Phosphorgehalt gekennzeichnet, was aus ernährungsphysiologischer Sicht vorteilhaft ist.
    Notizen: Summary Twenty-three mineral elements were investigated for their presence in someAgaricus andPleurotus species and their cultivated sorts. On the basis of the results, the following conclusions can be made. TheAgaricus species have remarkable accumulations of arsenic that are seldom reported in the literature (except forA. bisporus); this phenomenon could not be demonstrated in thePleurotus species. A remarkable accumulation of cadmium was found in theAgaricus species (except forA. bisporus andA. xanthoderma). A accumulation of copper was measured in theAgaricus fruit bodies (25–260 mg/kg), while the average copper level in thePleurotus species was 12.6 mg/kg. Only theAgaricus species can be characterized by an increased potassium and phosphorus content and this is advantageous from the point of view of nutritional-physiology.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 64 (1986), S. 1134-1138 
    ISSN: 1432-1440
    Schlagwort(e): Hemangiosarcoma ; Angiosarcoma ; Angioendothelioma ; Heart tumor ; Echocardiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The clinical appearance, typical localization, diagnostic procedure and the treatment of hemangiosarcoma — the most frequent malignant tumor of the heart are reported by the case of a 27 years old woman. The patient suffered from dyspnea, congestion of the superior caval vein and paroxysmal tachycardia. X-ray showed cardiac enlargement due to pericardial effusion. Echocardiography revealed a large tumor in the right atrium. Computertomography and angiocardiography showed tumor masses at the orifice of the superior caval vein and a bypass of the blood flow via the azygos vein. Thoracotomy yielded an inoperable hemangiosarcoma. By the combined treatment of irradiation and chemotherapy the cardiac tumor completely disappeared, the patient was temporary symptomless. Later metastases occured and the patient died 13 months after diagnosis.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 64 (1986), S. 1183-1185 
    ISSN: 1432-1440
    Schlagwort(e): Salt restriction ; Weight reduction ; Hypertension ; Intracellular electrolytes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In 16 essential hypertensives on a program of energy restriction (800 kcal/day) with and without simultaneous salt restriction, the effects on blood pressure and intracellular Na+ and Ca2+ in red blood cells were studied. A decrease in blood pressure and intracellular free Na+ and Ca2+ was only observed in the cases of simultaneous energy and salt restriction. The beneficial effect of weight reduction in hypertension thus depends on a diminished salt intake and is probably mediated by changes in intracellular free Ca2+.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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