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11

Digitale Medien

Blaschkolineäre Dermatitis im Erwachsenenalter (Morbus Grosshans-Marot) mit antinukleären Antikörpern (2000)

Lipsker, D. ; Stark, J. ; Schneider, G.-A.

Springer

Der Hautarzt 51 (2000), S. 774-777

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ISSN: 1432-1173

Schlagwort(e): Schlüsselwörter Morbus Grosshans-Marot ; Blaschkitis ; Lichen striatus ; Antinukleäre Antikörper ; Kutanes Mosaik ; Keywords Grosshand-Marot disease ; Blaschkitis ; Lichen striatus ; Antinuclear antibodies ; Cutaneous mosaicism

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Beschreibung / Inhaltsverzeichnis: Abstract E. Grosshans and L. Marot first described blaschkitis in 1990 as a linear inflammatory dermatitis following lines of Blaschko in an adult patient. We report another case which occurred in a 38-year-old woman who developed an extensive, linear, erythematosquamous dermatitis involving the face, all limbs and the trunk. The patient's serum tested positive for antinuclear antibodies at a dilution of 1:640. The lesions regressed spontaneously within 4 weeks. Blaschkitis is a distinct entity which corresponds neither to a known inflammatory dermatitis in the lines of Blaschko nor to an hamartoma nor to an X-linked disease. Cutaneous antigenic mosaicism, the expression of which might be induced by a viral infection, could trigger this localized inflammatory T-cell response. This hypothesis relates blaschkitis to other cutaneous autoimmune diseases, as does the presence of antinuclear antibodies. We therefore suggest renaming this type of inflammatory dermatitis Grosshans-Marot disease in honour to the dermatologists who first described the entity.

Notizen: Zusammenfassung Die “Blaschkitis”, eine blaschkolineäre Dermatitis im Erwachsenenalter, wurde von E. Grosshans und L. Marot 1990 erstmals als Entität beschrieben. Wir berichten von einem weiteren Fall einer “Blaschkitis” bei einer 38-jährigen Patientin ohne Vorerkrankungen, die an Kopf, Hals, Armen, Beinen und extremitätennahen Rumpfbereichen blaschkolineäre erythematosquamöse Läsionen entwickelte. Es fanden sich antinukleäre Antikörper mit einem Titer von 1:640. Spontane Abheilung trat innerhalb von 4 Wochen ein. Bei der “Blaschkitis” handelt es sich weder um eine blaschkolineäre Variante einer bekannten Dermatose noch um eine hamartomatöse Fehlbildung noch um einen X-chromosomal-dominanten Gendefekt. Ein Mosaik kutaner Antigene mit Expression im Laufe des Lebens (z. B. virusinduziert) könnte zu dieser blaschkolineären T-lymphozytären Entzündungsreaktion führen. Diese Theorie rückt die blaschkolineäre Dermatitis im Erwachsenenalter in die Nähe der Autoimmunerkrankungen, ebenso die gefundenen antinukleären Antikörper. Nachdem es sich bei der “Blaschkitis” um eine eigenständige Entität handelt und verschiedene Namengebungen sich international nicht durchsetzen konnten, möchten wir vorschlagen, sie nach den Erstbeschreibern Morbus Grosshans-Marot zu benennen.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s001050051214

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12

Digitale Medien

The principle of “conservation of total axonal arborizations”: massive compensatory sprouting in the hamster subcortical visual system after early tectal lesions (1988)

Sabel, B. A. ; Schneider, G. E.

Springer

Experimental brain research 73 (1988), S. 505-518

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ISSN: 1432-1106

Schlagwort(e): Visual system ; Neuroplasticity ; Axon-sprouting ; Pruning

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Unilateral lesions of the right superior colliculus (SC) were made in hamsters on the day after birth. In order to quantify the extent of abnormal innervation by left eye fibers in the diencephalon and midbrain, the left eye was removed on postnatal day 12 or 36, and after an appropriate survival time, the brains were stained for degenerating axons and axon terminals with the Fink-Heimer method. In additional cases, anterograde transport of 3H proline-leucine or horseradish peroxidase was used to assess left eye connectivity. In agreement with previous reports we found abnormal projections in the ventral nucleus of the lateral geniculate body (LGv), in the lateral posterior nucleus (LP) of the thalamus, and in the left SC (the ‘recrossing’ pathway). We also noted areas of abnormally heavy terminal fields arranged in patches in coronal sections in the dorsal nucleus of the lateral geniculate body (LGd). These patches arise from columns of dense innervation that are oriented along a rostral-to-caudal axis. If the right SC lesion was made large enough to diminish the recrossing pathway, retinofugal axons establish a significantly smaller distal terminal field in the left SC. In these cases, a corresponding increase in the size of terminal fields in all major proximal structures (LGd, LGv, LP, DTN) was observed. The sum of abnormal proximal growth (“compensatory sprouting”) was found to truly compensate for the distal loss of terminals. The evaluation of hamsters in which left eye connectivity was assessed at the age of 12 days revealed that lesion-induced patches of abnormal growth have already reached their full size by that time. These findings provide evidence for the ‘pruning -effect’ and demonstrate that retinofugal axons support a fixed number of terminal arborizations (the principle of ‘conservation of total axonal arborizations’).

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00406608

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13

Digitale Medien

Behavior evoked by electrical stimulation of the hamster superior colliculus (1988)

Northmore, D. P. M. ; Levine, E. S. ; Schneider, G. E.

Springer

Experimental brain research 73 (1988), S. 595-605

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ISSN: 1432-1106

Schlagwort(e): Superior colliculus ; Brain stimulation ; Orienting behavior ; Defensive behavior ; Hamster

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Syrian golden hamsters were implanted with fixed or moveable stimulating electrodes aimed at the superior colliculus (SC). Behavior was observed in response to trains of 0.1 ms pulses at 200 Hz while the animals were moving freely in an open arena or in their home cages. At threshold stimulating currents, the responses consisted almost entirely of freezing or contraversive turning, which occurred in two forms: fast turns, resembling orienting movements to sunflower seeds, and slow turns that were smooth and continuous. Other responses, including head raising and lowering, ipsiversive turning and backing movements were seen occasionally. Increasing the stimulating current usually gave a variety of responses, including circling movements, prolonged freezing, ipsilateral movements and running escape behavior. The sites in SC giving freezes at threshold tended to be located superficially (SO and above), or deep (SGP and below), while sites giving turns were in the intermediate layers. Most freeze sites occurred in the rostro-medial SC that represents the upper visual field, while turn sites occurred predominantly in caudo-lateral SC. Apart from the turns, most of the stimulated responses resembled natural defensive behavior, supporting the view that SC in rodents plays a role in organizing responses to predators, as well as in orienting behavior.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00406619

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14

Digitale Medien

Enhanced sprouting of retinotectal fibers after early superior colliculus lesions in hamsters treated with gangliosides (1988)

Sabel, B. A. ; Schneider, G. E.

Springer

Experimental brain research 71 (1988), S. 365-376

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ISSN: 1432-1106

Schlagwort(e): Gangliosides ; Brain damage ; Axonal sprouting ; Secondary degeneration ; Retinotectal system

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The effects of exogenous gangliosides on sprouting of optic tract axons was studied in hamsters which, after a right tectal lesion on the day after birth (P1), had an abnormal retinotectal projection from the left eye to the left superior colliculus (SC). Sprouting of these axons was induced by removing the competing input by right eye removal on postnatal day 9 (P9). Intraperitoneal GM1, given daily and started on P9, significantly stimulated the sprouting response. This was demonstrated by Fink-Heimer silver staining of anterograde axonal degeneration three days after the left eye was removed on P36. Terminal fields in the left SC were, in average, twice as large compared to controls. An estimate of the total number of terminals (silver stained particles) revealed a value of 7.9×106 for GM1 and 3.2×106 for control hamsters, respectively. Diencephalic structures which also receive collateral input from the sprouting optic tract did not show any alterations in the size of the terminal field due to GM1-treatment, suggesting that, in vivo, gangliosides fail to initiate sprouting in areas that have not previously been denervated. Unexpectedly, GM1-treated hamsters also had significantly smaller right SC damage and less left damage near the midline. Subsequent reanalysis of the data based on a lesion-matching procedure indicates that effects on reducing atrophy were independent of the GM1-enhanced sprouting of retinofugal axons. These findings provide the first direct evidence that exogenous GM1 stimulates lesion-induced axon sprouting in the mammalian brain.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00247496

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15

Digitale Medien

Littoral cell angioma of the spleen: CT and MR imaging appearance (2000)

Schneider, G. ; Uder, M. ; Altmeyer, K. ; [weitere]

Springer

European radiology 10 (2000), S. 1395-1400

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ISSN: 1432-1084

Schlagwort(e): Key words: Spleen – Tumor – CT – MRI

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract. We report a case of littoral cell angioma (LCA) of the spleen, a recently described splenic pathology, which imaging characteristics and pathologic morphology have been discussed only by a few authors. The imaging findings in unenhanced and contrast-enhanced MRI and CT as well as histologic specimen are presented. Diagnosis was made after elective splenectomy. Differential diagnosis of splenic tumors as well as the imaging findings in this particular case are discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s003300000345

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16

Digitale Medien

Compressed retinotectal projection in hamsters: Fewer ganglion cells project to tectum after neonatal tectal lesions (1981)

Udin, S. B. ; Schneider, G. E.

Springer

Experimental brain research 43 (1981), S. 261-269

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ISSN: 1432-1106

Schlagwort(e): Hamster ; Superior colliculus ; Compression ; Ganglion cells

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary After partial ablation of the superior colliculus (tectum) in neonatal hamsters, the whole extent of the visual field comes to be represented in a compressed map on the remaining tectal fragment. However, the total volume of tectal tissue in which retinotectal fibers arborize is less than normal. These observations suggest that the retinal ganglion cells which arborize in this reduced volume might arise throughout the whole extent of the retina but be fewer in number than normal. Alternatively, the ganglion cells which project to the tectum might be normal in number but reduced in terminal arbor size. To distinguish between these possibilities, we have used tectal injections of horseradish peroxidase to label retinal ganglion cells which project to the tectum. The numbers of labelled cells per mm2 of retina were counted in selected regions. In hamsters with small lesions, which left 80–85% of the tectum intact, the density of labelled retinal ganglion cells was normal. However, in hamsters with larger lesions, the density of labelled cells was significantly lower than normal.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00238367

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17

Digitale Medien

Voltage sensitive, high-conductance chloride channels in the luminal membrane of cultured pulmonary alveolar (type II) cells (1985)

Schneider, G. T. ; Cook, D. I. ; Gage, P. W. ; [weitere]

Springer

Pflügers Archiv 404 (1985), S. 354-357

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ISSN: 1432-2013

Schlagwort(e): Patch-clamp ; Chloride channels ; Pulmonary epithelium ; Cultured epithelial cells ; Cystic fibrosis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The properties of ion channels in patches from the luminal membrane of cultured monolayers of type II alveolar epithelial cells from adult rat lung have been studied. In excised patches, prepared as described to yield the “outside-out” configuration (with cesium ions in the bathing solutions to suppress currents arising from potassium channels), we observed anion-selective channels with a conductance of 350–400 pS, and burst lengths lasting seconds. When patches were bathed in solutions with equal chloride concentrations, channels opened and closed spontaneously at membrane voltages close to zero, but tended to close when the potential was shifted by ±10 mV, particularly in the negative direction. Other anions could pass through these channels with a permeability sequence of I(1.5)〉Br(1.02)=〉Cl(1.00)〉NO3(0.9)〉gluconate(0.6) but there was a very low permeability for sodium (P Na/P Cl=0.015±0.006). Calcium ions reduced channel conductance. The channels probably have a role to play in salt absorption by this epithelium, but insufficient information is available about how sodium crosses it for the role of the anion channels in transport to be defined with confidence.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00585348

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18

Digitale Medien

Chalcides and pnictides of group VIII transition metals: Far-infrared spectroscopic studies on compounds MX 2, MXY, and MY 2 with pyrite, marcasite, and arsenopyrite structure (1983)

Lutz, H. D. ; Schneider, G. ; Kliche, G.

Springer

Physics and chemistry of minerals 9 (1983), S. 109-114

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ISSN: 1432-2021

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik

Notizen: Abstract The far-infrared (FIR) spectra of pyrites, marcasites and loellingites, and arsenopyrites of the type MX 2, MY 2, and MXY with M=Fe, Co, Ru, Rh, Os, Ir X=S, Se, Te, and Y=P, As, and Sb have been studied, including group theoretical treatment of the phonon modes. The internal Y - Y and X - Y stretching modes, infrared (IR) allowed only in the case of the arsenopyrites, have been found to be in the range 440–490, 470–510, 450–490, 430–450 and 400–420 cm−1 for MP 2, MPS, MPSe, MAsS, and MSbS type compounds, respectively. From the obtained spectra intensity weighted mean phonon frequencies, i.e. central frequencies as defined by Plendl (1961), and mass weighted ones have been calculated and interpreted in terms of the strength of the MX and MY bonds, especially comparing 3d, 4d, and 5d transition metal compounds. Method of preparation and X-ray data of the chalcides and pnictides studied are also given.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00308366

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19

Digitale Medien

The common jellyfish Aurelia aurita: standing stock, excretion and nutrient regeneration in the Kiel Bight, Western Baltic (1989)

Schneider, G.

Springer

Marine biology 100 (1989), S. 507-514

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ISSN: 1432-1793

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract The population dynamics, ammonia and inorganic phosphate excretion, and nutrient regeneration of the common jellyfish Aurelia aurita was investigated from 1982 to 1984 in the Kiel Bight, western Baltic Sea. During summer 1982, medusae abundance ranged between 14 and 23 individuals 100 m-3, biomass was estimated at about 5 g C 100 m-3 and the mean final diameter of individuals was 22 cm. Abundance, based on numbers, in 1983 and 1984 was an order of magnitude lower; biomass was less than 2 g C 100 m-3 and jellyfish grew to 30 cm. During the summers of 1983 and 1984, A. aurita biomass constituted roughly 40% of that of the total zooplankton〉200 μm. In 1982, for which zooplankton data were lacking, it was assumed that medusae biomass was greater than that of all other zooplankton groups. Total ammonia excretion ranged between 6.5 and 36 μmol h-1 individual-1, whereas inorganic phosphate release was 1.4 to 5.7 μmol h-1 individual-1. Allometric equations were calculated and exponents of 0.93 for NH4−N release and 0.87 for PO4−P excretion were determined. Nitrogen and phosphorus turnover rates were 5.4 and 14.6% d-1, respectively. In 1982, the medusae population released 1 100 μmol NH4−N m-2 d-1, about 11% of the nitrogen requirements of the phytoplankton. The inorganic phosphate excretion (150 μmol m-2 d-1) sustained 23% of the nutrient demands of the primary producers. In the other two years the nutrient cycling of the medusae was much less important, and satisfied only 3 to 6% of the nutrient demands. It is suggested that in some years A. aurita is the second most important source of regenerated nutrients in Kiel Bight, next to sediment.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00394827

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20

Digitale Medien

CNS cysticercosis — A problem of differential diagnosis (1982)

Popper, H. ; Bertha, G. ; Walter, G. F. ; [weitere]

Springer

European archives of psychiatry and clinical neuroscience 231 (1982), S. 369-374

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ISSN: 1433-8491

Schlagwort(e): Cysticercosis ; Central nervous system ; Spinal cord myelography

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Although a well-known disease worldwide, cerebral cysticerosis in European countries is a rare event. Due to increased travel to East-Asian and Latin American countries it is possible that the occurrence of brain cysticercosis will become more frequent. These facts should remind us of the possibility of cysticercosis of the nervous system. A case of cerebral and spinal cord cysticercosis is presented, causing symptoms of progressive dementia with ventricular occlusion and hydrocephalus. Differential diagnosis causes a major problem. It is shown that myelography may demonstrate characteristic features of the disease.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00345592

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