ISSN:
1546-1696
Quelle:
Nature Archives 1869 - 2009
Thema:
Biologie
,
Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
Notizen:
[Auszug] Cholesterol-conjugated siRNAs can silence gene expression in vivo. Here we synthesize a variety of lipophilic siRNAs and use them to elucidate the requirements for siRNA delivery in vivo. We show that conjugation to bile acids and long-chain fatty acids, in addition to cholesterol, mediates siRNA ...
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1038/nbt1339
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