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  • 1
    Electronic Resource
    Electronic Resource
    Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Activated protein C (APC) is a serine protease that plays a central role in physiological anticoagulation, and has more recently been shown to be a potent anti-inflammatory mediator. Using cultured human cells, we show here that APC up-regulates the angiogenic promoters matrix metalloproteinase-2 in skin fibroblasts and umbilical vein endothelial cells, vascular endothelial growth factor in keratinocytes and fibroblasts, and monocyte chemoattractant protein-1 in fibroblasts. In the chick embryo chorioallantoic membrane assay, APC promoted the granulation/remodeling phases of wound healing by markedly stimulating angiogenesis as well as promoting reepithelialization. In a full-thickness rat skin-healing model, a single topical application of APC enhanced wound healing compared to saline control. APC-treated wounds had markedly more blood vessels on day 7 and a significantly lower infiltration of neutrophils at days 4 and 7. The broad spectrum matrix metallo-proteinas, GM6001, prevented the ability of APC to promote wound healing. In summary, our results show that APC promotes cutaneous wound healing via a complex mechanism involving stimulation of angiogenesis and inhibition of inflammation. These unique properties of APC make it an attractive therapeutic agent to promote the healing of chronic wounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.00130311.x
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  • 2
    Electronic Resource
    Electronic Resource
    Wound matrix attachment regulates actin content and organization in cells of the granulation tissue (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Actin cytoskeletal polymerization is associated with a pro-proliferative, pro-survival state. We hypothesized that the actin polymerization of wound cells is increased in the presence of wound matrix attachment and is decreased after disruption of this attachment. Musculocutaneous flap and wound splinting models were used to investigate the effect of wound matrix attachment on the actin cytoskeleton. Disruption of wound matrix attachment was accomplished by incision of the wound matrix/dermis interface (wound matrix release) and/or desplinting. Polymerized actin was assayed with phalloidin labeling of wound specimens 24 hours after disruption of attachment and a method to quantify the content and organization of polymerized actin in granulation tissue was used. Disruption of wound matrix attachment decreased the content of polymerized actin, the actin staining intensity, and the actin fiber organization in the granulation tissue of both the flap and splint models. Disruption of wound matrix attachment decreased actin polymerization and fiber organization in the granulation tissue. Our data support the concept that the state of wound matrix attachment regulates the actin cytoskeleton of wound cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130111.x
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  • 3
    Electronic Resource
    Electronic Resource
    002
How Painful is Wound Care? (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study examined adult hospitalized patients’ responses to wound care pain and its treatment. Wound care included dressing change, packing, irrigation, and debridement. The subjective experience of pain intensity was measured with a numeric rating scale (NRS) prior to, immediately after, and 10 minutes after completion of the procedure. The sample was composed of 412 subjects. Most were male (52.3%), white (73.9%), had one wound (59.5%), and had undergone surgery (73.9%). When pain intensity was compared over time, pain intensity was greatest (NRS 4.4, SD 3.2) during the procedure (p 〈 .023), and nonsurgical patients experienced significantly greater pain than surgical patients (p = .002)(NRS 5.3, SD 3.0, NRS 4.1, SD3.2, respectively). Most patients underwent multiple wound care procedures. When the pain intensity of undergoing only a dressing change (n = 61), only packing (n = 41), or ≥2 procedures (n = 258) was examined by whether subjects had undergone surgery or no surgery, nonsurgical patients reported greater pain intensity with dressing change (p 〈 .001) and ≥2 procedures (p 〈 .001). Few subjects received analgesics (7.3% surgical patients 5.9% nonsurgical); there was no difference by group in the amount of opioid administered (p = .821). Sedatives and NSAIDS were rarely used. Treatment with pain medication was examined over time. Those with least pain received significantly less pain medication when compared with those who received premedication only and those who received medication prior to and during the procedure (p 〈 .05). Findings show wound care is painful and wound care pain is undertreated. Further research is needed to address the effect of pain on wound-related patient outcomes and strategies to minimize pain.Acknowledgment:  Funded by the AACN, K. Puntillo, PI
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130215b.x
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  • 4
    Electronic Resource
    Electronic Resource
    The Influence of Ethnicity and Generational Status on Parent and Family Relations Among Chinese and Filipino Adolescents (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Public health nursing 22 (2005), S. 0 
    Details
    ISSN: 1525-1446
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Objective: The purpose of this study was to explore the influence of ethnic and generational differences on perceptions about parent and family relationships in a nationally representative sample of Chinese and Filipino adolescents living in the United States. Design: This was a cross-sectional descriptive study, utilizing data from the National Longitudinal Study on Adolescent Health. Sample: The sample was weighted to produce a nationally representative sample, based on 216 self-identified Chinese and 387 self-identified Filipino adolescents. Results: Results indicated that generational status plays a role in predicting how adolescents perceive the parent–adolescent relationship. Conclusions: Findings provide a basis by which community health nurses can begin to understand the uniqueness of Asian subgroups, as well as generations of immigrant youth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0737-1209.2005.220603.x
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  • 5
    Electronic Resource
    Electronic Resource
    Scalp Histology in RAPP-Hodgkin Syndrome (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report unique histologic findings in scalp biopsies from two family members with Rapp-Hodgkin syndrome. Rapp-Hodgkin and the related AEC syndrome show a primary scarring alopecia and pili torti. The syndromes, which are related to ectodactyly, ectodermal dysplasia and cleft lip/palate syndrome, have been credited to mutations in the TP63 gene. Most notable on biopsy is a primary scarring alopecia and abnormal hair shaft shape. Calcification in the outer root sheath epithelium, the basement membrane of the lower segment and within naked hair shafts is present. Neutrophils and bacterial rods and cocci are adjacent to the hair shaft in the superior segment, associated with dilated follicular ostia. Perifollicular fibrosis is associated with a variety of inflammatory cell types, mostly lymphocytic. One sample shows interfollicular irregular psoriasiform epidermal hyperplasia with parakeratosis, compact orthokeratosis, hypergranulosis, and intraepidermal neutrophils. Follicular architecture is abnormal with abrupt and linear loss of nucleated matrical cells (B fringe of Adamson). The line of Ayber measures 0.30 mm on average. Hair shafts measure up to 0.16 mm, with variable abnormal cross sectional shape, usually square. Outer root sheath epithelium is disorganized with slight cellular pleomorphism, and the cuticle of the inner and outer root sheath is irregular in thickness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320hg.x
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  • 6
    Electronic Resource
    Electronic Resource
    Porokeratosis Causing Change in Melanocytic Nevi (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Porokeratosis is an uncommon cause of clinical change in pigmented lesions. We report two cases of so-called “collision” lesions, in which the cause of clinical change in melanocytic nevi was porokeratosis. One biopsy was submitted concurrently with a biopsy from another anatomic site, which was a superficial pattern basal cell carcinoma. Both the melanocytic nevus and the basal cell carcinoma contained coronoid lamellae, focal diminution of the granular layer and subjacent dyskeratotic keratinocytes, consistent with disseminated superficial actinic porokeratosis (DSAP). The melanocytic nevus, from the lower back, was a broad compound melanocytic nevus, associated with elongated, pigmented rete (lentiginous) and small melanocytes in the papillary and superficial reticular dermis (superficial congenital pattern). There was no evidence of external irritation. The second case showed a similar coronoid lamella, focal diminution of the granular layer and dyskeratotic keratinocytes. There was additional parakeratosis away from the parakeratotic column and a lichenoid host response, suggesting external irritation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320hf.x
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  • 7
    Electronic Resource
    Electronic Resource
    A Review of a Preventable Poison: Pediatric Lead Poisoning (2005)
    Oxford, UK : Blackwell Science Inc
    Journal for specialists in pediatric nursing 10 (2005), S. 0 
    Details
    ISSN: 1744-6155
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: PURPOSE.  A review of lead poisoning in pediatric populations enables nurses to increase their knowledge base about lead poisoning and to further the work on the Healthy People 2010 goal of eliminating childhood lead poisoning as a public health issue in the United States. CONCLUSION.  Nurses should be aware of and use the variety of primary, secondary, and tertiary prevention strategies that are available to address pediatric lead poisoning. PRACTICE IMPLICATIONS.  Prevention, education, and evidence-based treatment plans can decrease the occurrence of pediatric lead poisoning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-6155.2005.00034.x
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  • 8
    Electronic Resource
    Electronic Resource
    Long-Term Outcomes of a Telephone Intervention After an ICD (2005)
    350 Main Street , Malden , MA 02148-5018 , USA and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Pacing and clinical electrophysiology 28 (2005), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The purpose of this study was to determine the long-term benefits of participating in a structured, 8-week educational telephone intervention delivered by expert cardiovascular nurses post-ICD. The intervention was aimed to (1) increase physical functioning, (2) increase psychological adjustment, (3) improve self-efficacy in managing the challenges of ICD recovery, and (4) lower levels of health care utilization over usual care in the first 12 months post-ICD. This article reports on the 6- and 12-month outcomes of the nursing intervention trial. Methods and Results: A two-group (N = 168) randomized control group design was used to evaluate intervention efficacy with persons receiving an ICD for the secondary prevention of sudden cardiac arrest. Measures were obtained at baseline, 6 and 12 months post hospitalization. Outcomes included (1) physical functioning (Patient Concerns Assessment [PCA], Short Form Health Survey [SF-12], ICD shocks), (2) psychological adjustment (State-Trait Anxiety Inventory [STAI], Centers for Epidemiologic Studies–Depression [CES-D], fear of dying), (3) self-efficacy (Sudden Cardiac Arrest–Self-Efficacy [SCA-SE], Sudden Cardiac Arrest–Behavior [SCA-B], Sudden Cardiac Arrest–Knowledge [SCA-K]), and (4) health care utilization (emergency room [ER] visits, outpatient visits, hospitalizations). Using repeated measures ANOVA, the 6- and 12-month benefits of the intervention over usual care were in reductions in physical concerns (P = 0.006), anxiety (P = 0.04), and fear of dying (P = 0.01), with enhanced self-confidence (P = 0.04) and knowledge (P = 0.001) to manage ICD recovery. There were no statistically significant differences between the groups on total outpatient visits, hospitalizations, or ER visits over 12 months. Conclusion: A structured 8-week post-hospital telephone nursing intervention after an ICD had sustained 12-month improvements on patient concerns, anxiety, fear of dying, self-efficacy, and knowledge. Results may not apply to individuals with congestive heart failure who receive an ICD for primary prevention of sudden cardiac arrest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.2005.09500.x
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