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  • 1
    Publication Date: 2017-04-04
    Description: In the last twelve years, Mt. Etna, located in eastern Sicily, has produced a great number of explosive eruptions. Volcanic plumes have risen to several km above sea level and created problems for aviation and the communities living near the volcano. A reduction of hazards may be accomplished using remote sensing techniques to evaluate important features of volcanic plumes. Since 2000, the Multiangle Imaging SpectroRadiometer (MISR) on board NASA’s Terra spacecraft has been extensively used to study aerosol dispersal and to extract the three-dimensional structure of plumes coming from anthropogenic or natural sources, including volcanoes. In the present work, MISR data from several explosive events occurring at Etna are analyzed using a program named MINX (MISR INteractive eXplorer). MINX uses stereo matching techniques to evaluate the height of the volcanic aerosol with a precision of a few hundred meters, and extracts aerosol properties from the MISR Standard products. We analyzed twenty volcanic plumes produced during the 2000, 2001, 2002–03, 2006 and 2008 Etna eruptions, finding that volcanic aerosol dispersal and column height obtained by this analysis is in good agreement with ground-based observations. MISR aerosol type retrievals: (1) clearly distinguish volcanic plumes that are sulphate and/or water vapor dominated from ash-dominated ones; (2) detect even low concentrations of volcanic ash in the atmosphere; (3) demonstrate that sulphate and/or water vapor dominated plumes consist of smaller-sized particles compared to ash plumes. This work highlights the potential of MISR to detect important volcanic plume characteristics that can be used to constrain the eruption source parameters in volcanic ash dispersion models. Further, the possibility of discriminating sulphate and/or water vapor dominated plumes from ash-dominated ones is important to better understand the atmospheric impact of these plumes
    Description: Published
    Description: D06210
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: JCR Journal
    Description: restricted
    Keywords: volcanic ash plume ; MISR ; 01. Atmosphere::01.01. Atmosphere::01.01.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 3
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    In:  [Talk] In: 43th International Liège Colloquium on Ocean Dynamics Tracers of physical and biogeochemical processes, past changes and ongoing anthropogenic impacts, 02.-06.05.2011, Liege, Belgium .
    Publication Date: 2015-01-07
    Type: Conference or Workshop Item , NonPeerReviewed
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  • 4
    Publication Date: 2012-05-02
    Description: The human placenta is key to pregnancy outcome, and the elevated oxidative stress present in many complicated pregnancies contributes to placental dysfunction and suboptimal pregnancy outcomes. We tested the hypothesis that pomegranate juice, which is rich in polyphenolic antioxidants, limits placental trophoblast injury in vivo and in vitro. Pregnant women with singleton pregnancies were randomized at 35~38 wk gestation to 8 oz/day of pomegranate juice or apple juice (placebo) until the time of delivery. Placental tissues from 12 patients (4 in the pomegranate group and 8 in the control group) were collected for analysis of oxidative stress. The preliminary in vivo results were extended to oxidative stress and cell death assays in vitro. Placental explants and cultured primary human trophoblasts were exposed to pomegranate juice or glucose (control) under defined oxygen tensions and chemical stimuli. We found decreased oxidative stress in term human placentas from women who labored after prenatal ingestion of pomegranate juice compared with apple juice as control. Moreover, pomegranate juice reduced in vitro oxidative stress, apoptosis, and global cell death in term villous explants and primary trophoblast cultures exposed to hypoxia, the hypoxia mimetic cobalt chloride, and the kinase inhibitor staurosporine. Punicalagin, but not ellagic acid, both prominent polyphenols in pomegranate juice, reduced oxidative stress and stimulus-induced apoptosis in cultured syncytiotrophoblasts. We conclude that pomegranate juice reduces placental oxidative stress in vivo and in vitro while limiting stimulus-induced death of human trophoblasts in culture. The polyphenol punicalagin mimics this protective effect. We speculate that antenatal intake of pomegranate may limit placental injury and thereby may confer protection to the exposed fetus.
    Print ISSN: 0193-1849
    Electronic ISSN: 1522-1555
    Topics: Medicine
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  • 5
    Publication Date: 2012-04-12
    Description: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurodegenerative disorder recognized in fragile X premutation carriers. Using Drosophila , we previously identified elongated non-coding CGG repeats in FMR1 allele as the pathogenic cause of FXTAS. Here, we use this same FXTAS Drosophila model to conduct a chemical screen that reveals small molecules that can ameliorate the toxic effects of fragile X premutation ribo-CGG (rCGG) repeats, among them several known phospholipase A 2 (PLA 2 ) inhibitors. We show that specific inhibition of PLA 2 activity could mitigate the neuronal deficits caused by fragile X premutation rCGG repeats, including lethality and locomotion deficits. Furthermore, through a genetic screen, we identified a PLA 2 Drosophila ortholog that specifically modulates rCGG repeat-mediated neuronal toxicity. Our results demonstrate the utility of Drosophila models for unbiased small molecule screens and point to PLA 2 as a possible therapeutic target to treat FXTAS.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 6
    Publication Date: 2013-08-21
    Description: Senescence is a stable proliferation arrest, associated with an altered secretory pathway, thought to promote tumor suppression and tissue aging. While chromatin regulation and lamin B1 down-regulation have been implicated as senescence effectors, functional interactions between them are poorly understood. We compared genome-wide Lys4 trimethylation on histone H3 (H3K4me3) and H3K27me3 distributions between proliferating and senescent human cells and found dramatic differences in senescence, including large-scale domains of H3K4me3- and H3K27me3-enriched "mesas" and H3K27me3-depleted "canyons." Mesas form at lamin B1-associated domains (LADs) in replicative senescence and oncogene-induced senescence and overlap DNA hypomethylation regions in cancer, suggesting that pre-malignant senescent chromatin changes foreshadow epigenetic cancer changes. Hutchinson-Gilford progeria syndrome fibroblasts (mutant lamin A) also show evidence of H3K4me3 mesas, suggesting a link between premature chromatin changes and accelerated cell senescence. Canyons mostly form between LADs and are enriched in genes and enhancers. H3K27me3 loss is correlated with up-regulation of key senescence genes, indicating a link between global chromatin changes and local gene expression regulation. Lamin B1 reduction in proliferating cells triggers senescence and formation of mesas and canyons. Our data illustrate profound chromatin reorganization during senescence and suggest that lamin B1 down-regulation in senescence is a key trigger of global and local chromatin changes that impact gene expression, aging, and cancer.
    Print ISSN: 0890-9369
    Topics: Biology
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  • 7
    Publication Date: 2013-05-09
    Description: Circadian disruption has deleterious effects on metabolism. Global deletion of Bmal1, a core clock gene, results in β-cell dysfunction and diabetes. However, it is unknown if this is due to loss of cell-autonomous function of Bmal1 in β cells. To address this, we generated mice with β-cell clock disruption by deleting Bmal1 in β cells (β-Bmal1 –/– ). β-Bmal1 –/– mice develop diabetes due to loss of glucose-stimulated insulin secretion (GSIS). This loss of GSIS is due to the accumulation of reactive oxygen species (ROS) and consequent mitochondrial uncoupling, as it is fully rescued by scavenging of the ROS or by inhibition of uncoupling protein 2. The expression of the master antioxidant regulatory factor Nrf2 ( n uclear factor erythroid 2- r elated f actor 2) and its targets, Sesn2, Prdx3, Gclc, and Gclm, was decreased in β-Bmal1 –/– islets, which may contribute to the observed increase in ROS accumulation. In addition, by chromatin immunoprecipitation experiments, we show that Nrf2 is a direct transcriptional target of Bmal1. Interestingly, simulation of shift work-induced circadian misalignment in mice recapitulates many of the defects seen in Bmal1-deficient islets. Thus, the cell-autonomous function of Bmal1 is required for normal β-cell function by mitigating oxidative stress and serves to preserve β-cell function in the face of circadian misalignment.
    Print ISSN: 0270-7306
    Electronic ISSN: 1098-5549
    Topics: Biology , Medicine
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  • 8
    Publication Date: 2013-05-08
    Description: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share phenotypic and pathologic overlap. Recently, an expansion of GGGGCC repeats in the first intron of C9orf72 was found to be a common cause of both illnesses; however, the molecular pathogenesis of this expanded repeat is unknown. Here we developed both Drosophila...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 9
    Publication Date: 2013-07-02
    Description: The role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve (SN) stimulation was studied in anesthetized female rats, using the rat model of isovolumetric bladder contraction. SN stimulation at a fixed frequency of 10 Hz attenuated bladder contraction frequency; the magnitude of the inhibition was directly proportional to the current intensity. Neither the -opioid antagonist nor-binaltorphimine (2 mg/kg iv) nor the -opioid antagonist naltrindole (5 mg/kg iv) attenuated the bladder inhibitory response to SN stimulation. In contrast, the μ-opioid receptor antagonist naloxone (NLX; 0.03 mg/kg iv) blocked the inhibitory responses evoked by SN stimulation at therapeutic current intensities at ≤1 x motor threshold current (T mot ). An action at spinal and supraspinal centers was further confirmed by the ability of intrathecal or intracerebroventricular administration of NLX methiodide to attenuate the bladder inhibitory effects of 1 x T mot SN stimulation. The magnitude of SN-mediated neuromodulation using therapeutically relevant stimulation intensity (T mot ) is equivalent to 0.16 mg/kg of systemically administered morphine, which produces 50% inhibition of bladder contraction frequency. These results suggest that the inhibitory effects of lower intensity SN stimulation may be mediated through the release of endogenous μ-opioid peptides. Additionally, these data suggest that neuromodulation may offer a mode of treating the symptoms of overactive bladder with efficacy equal to the opioid drugs but without their liability for abuse and dependence.
    Print ISSN: 1931-857X
    Electronic ISSN: 1522-1466
    Topics: Medicine
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  • 10
    Publication Date: 2014-08-16
    Description: We use the Illustris simulations to gain insight into the build-up of the outer, low-surface brightness regions which surround galaxies. We characterize the stellar haloes by means of the logarithmic slope of the spherically averaged stellar density profiles, α STARS at z  = 0, and we relate these slopes to the properties of the underlying dark matter (DM) haloes, their central galaxies, and their assembly histories. We analyse a sample of ~5000 galaxies resolved with more than 5 10 4 particles each, and spanning a variety of morphologies and halo masses (3 10 11 ≤ M vir 10 14 M ). We find a strong trend between stellar halo slope and total halo mass, where more massive objects have shallower stellar haloes than the less massive ones (–5.5 ± 0.5 〈 α STARS  〈 –3.5 ± 0.2 in the studied mass range). At fixed halo mass, we show that disc-like, blue, young, and more massive galaxies are surrounded by significantly steeper stellar haloes than elliptical, red, older, and less massive galaxies. Overall, the stellar density profiles fall off much more steeply than the underlying DM, and no clear trend holds between stellar slope and DM halo concentration. However, DM haloes which formed more recently, or which accreted larger fractions of stellar mass from infalling satellites, exhibit shallower stellar haloes than their older analogues with similar masses, by up to α STARS  ~ 0.5–0.7. Our findings, combined with the most recent measurements of the strikingly different stellar power-law indices for M31 and the Milky Way, appear to favour a massive M31, and a Milky Way characterized by a much quieter accretion history over the past 10 Gyr than its companion.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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