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  • 1
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 9 (2008): Q07022, doi:10.1029/2008GC002047.
    Description: Ultrahigh-resolution bathymetric maps (25 cm grid) are used to quantify the physical dimensions of and spatial relationships between tectonic, volcanic, and hydrothermal features at six hydrothermal vent fields in the Lau back-arc basin. Supplemented with near-bottom photos, and nested within regional DSL-120A side-scan sonar data, these maps provide insight into the nature of hydrothermal systems along the Eastern Lau Spreading Center (ELSC) and Valu Fa Ridge (VFR). Along-axis transitions evident in localized volcanic morphology and tectonic characteristics include a change from broad low-relief volcanic domes (hundreds of meters wide, 〈10 m tall) that are dominated by pillow and lobate lava morphologies and are cut by faults and fissures to higher aspect ratio volcanic domes (tens of meters wide, tens of meters tall) dominated by aa-type lava morphologies, with finger-like flows, and few tectonic structures. These along-axis differences in localized seafloor morphology suggest differences in hydrothermal circulation pathways within the shallow crust and correlate with regional transitions in a variety of ridge properties, including the large-scale morphology of the ridge axis (shallow axial valley to axial high), seafloor lava compositions, and seismic properties of the upper crust. Differences in morphologic characteristics of individual flows and lava types were also quantified, providing an important first step toward the remote characterization of complex terrains associated with hydrothermal vent fields.
    Description: Support for field and laboratory studies was provided by the National Science Foundation under grant OCE02-41796 (M.K.T.). Additional support for data analysis and integration was provided by the National Science Foundation under grant OCE03-28117 (S.M.C.).
    Keywords: Bathymetry ; Submarine lava morphology ; Back-arc ridges ; Lau Basin
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 2
    Publication Date: 2014-07-09
    Description: Author(s): Alexandre Zanchet, Octavio Roncero, Anaís Dorta-Urra, Alfredo Aguado, José Ignacio Martínez, Fernando Flores, and Nicolás Lorente Nonequilibrium Green's functions calculations based on density functional theory show a direct link between the initial stages of H2 dissociation on a gold atomic wire and the electronic current supported by the gold wire. The simulations reveal that for biases below the stability threshold of the w... [Phys. Rev. B 90, 041404] Published Tue Jul 08, 2014
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 3
    Publication Date: 2014-09-05
    Description: Titanosaurian sauropod dinosaurs were the most diverse and abundant large-bodied herbivores in the southern continents during the final 30 million years of the Mesozoic Era. Several titanosaur species are regarded as the most massive land-living animals yet discovered; nevertheless, nearly all of these giant titanosaurs are known only from very incomplete fossils, hindering a detailed understanding of their anatomy. Here we describe a new and gigantic titanosaur, Dreadnoughtus schrani, from Upper Cretaceous sediments in southern Patagonia, Argentina. Represented by approximately 70% of the postcranial skeleton, plus craniodental remains, Dreadnoughtus is the most complete giant titanosaur yet discovered, and provides new insight into the morphology and evolutionary history of these colossal animals. Furthermore, despite its estimated mass of about 59.3 metric tons, the bone histology of the Dreadnoughtus type specimen reveals that this individual was still growing at the time of death. Scientific Reports 4 doi: 10.1038/srep06196
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 4
    Publication Date: 2014-07-04
    Description: Background: The recent occurrence and spread of African swine fever (ASF) in Eastern Europe is perceived as a serious risk for the pig industry in the European Union (EU). In order to estimate the potential risk of ASF virus (ASFV) entering the EU, several pathways of introduction were previously assessed separately. The present work aimed to integrate five of these assessments (legal imports of pigs, legal imports of products, illegal imports of products, fomites associated with transport and wild boar movements) into a modular tool that facilitates the visualization and comprehension of the relative risk of ASFV introduction into the EU by each analyzed pathway. Results: The framework's results indicate that 48% of EU countries are at relatively high risk (risk score 4 or 5 out of 5) for ASFV entry for at least one analyzed pathway. Four of these countries obtained the maximum risk score for one pathway: Bulgaria for legally imported products during the high risk period (HRP); Finland for wild boar; Slovenia and Sweden for legally imported pigs during the HRP. Distribution of risk considerably differed from one pathway to another; for some pathways, the risk was concentrated in a few countries (e.g., transport fomites), whereas other pathways incurred a high risk for 4 or 5 countries (legal pigs, illegal imports and wild boar). Conclusions: The modular framework, developed to estimate the risk of ASFV entry into the EU, is available in a public domain, and is a transparent, easy-to-interpret tool that can be updated and adapted if required. The model's results determine the EU countries at higher risk for each ASFV introduction route, and provide a useful basis to develop a global coordinated program to improve ASFV prevention in the EU.
    Electronic ISSN: 1746-6148
    Topics: Medicine
    Published by BioMed Central
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  • 5
    Publication Date: 2014-05-02
    Description: Background: The microbial community analysis of stools requires optimised and standardised protocols for their collection, homogenisation, microbial disruption and nucleic acid extraction. Here we examined whether different layers of the stool are equally representative of the microbiome. We also studied the effect of stool water content, which typically increases in diarrhoeic samples, and of a microbial disruption method on DNA integrity and, therefore, on providing an unbiased microbial composition analysis. Results: We collected faecal samples from healthy subjects and performed microbial composition analysis by pyrosequencing the V4 region of the 16S rRNA gene. To examine the effect of stool structure, we compared the inner and outer layers of the samples (N = 8). Both layers presented minor differences in microbial composition and abundance at the species level. These differences did not significantly bias the microbial community specific to an individual. To evaluate the effect of stool water content and bead-beating, we used various volumes of a water-based salt solution and beads of distinct weights before nucleic acid extraction (N = 4). The different proportions of water did not affect the UniFrac-based clustering of samples from the same subject However, the use or omission of a bead-beating step produced different proportions of Gram-positive and Gram-negative bacteria and significant changes in the UniFrac-based clustering of the samples. Conclusion: The degree of hydration and homogenisation of faecal samples do not significantly alter their microbial community composition. However, the use of bead-beating is critical for the proper detection of Gram-positive bacteria such as Blautia and Bifidobacterium.
    Electronic ISSN: 1471-2180
    Topics: Biology
    Published by BioMed Central
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  • 6
    Publication Date: 2012-02-03
    Description: Species Distribution Models ( SDMs ) were employed to assess the potential impact of climate change on the distribution of Pinus uncinata in the Pyrenees, where it is the dominant tree species in subalpine forest and alpine tree lines. Predicting forest response to climate change is a challenging task in mountain regions, but also a conservation priority. We examined the potential impact of spatial scale on SDM projections by conducting all analyses at four spatial resolutions. We further examined the potential effect of dispersal constraints by applying a threshold distance of maximal advancement derived from a spatially explicit, individual-based simulation model of tree line dynamics. Under current conditions, SDMs including climatic factors related to stress or growth limitation performed best. These models were then employed to project P. uncinata distribution under two emission scenarios, using data generated from several regional climate models. At the end of this century, P. uncinata is expected to migrate northwards and upwards, occupying habitat currently inhabited by alpine plant species. However, consideration of dispersal limitation and/or changing the spatial resolution of the analysis modified the assessment of climate change impact on mountain ecosystems, especially in the case of estimates of colonization and extinction at the regional scale. Our study highlights the need to improve the characterization of biological processes within SDMs , as well as to consider simultaneously different scales when assessing potential habitat loss under future climate conditions.
    Print ISSN: 1354-1013
    Electronic ISSN: 1365-2486
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Published by Wiley-Blackwell
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  • 7
    Publication Date: 2012-03-05
    Description: Structure and catalytic properties of the most complex intergrown zeolite ITQ-39 determined by electron crystallography Nature Chemistry 4, 188 (2012). doi:10.1038/nchem.1253 Authors: Tom Willhammar, Junliang Sun, Wei Wan, Peter Oleynikov, Daliang Zhang, Xiaodong Zou, Manuel Moliner, Jorge Gonzalez, Cristina Martínez, Fernando Rey & Avelino Corma Solving the structure of zeolites is often challenging because of their small particle size. Now, electron crystallography reveals the structure of a family of complex intergrown zeolite materials. These zeolites contain unique pair-wise 12-ring channels that intersect with 10-ring channels, and are promising catalysts for converting gasoline into diesel fuel.
    Print ISSN: 1755-4330
    Electronic ISSN: 1755-4349
    Topics: Chemistry and Pharmacology
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  • 8
    Publication Date: 2012-04-15
    Description: Species Distribution Models (SDMs) were employed to assess the potential impact of climate change on the distribution of Pinus uncinata in the Pyrenees, where it is the dominant tree species in subalpine forest and alpine tree lines. Predicting forest response to climate change is a challenging task in mountain regions but also a conservation priority. We examined the potential impact of spatial scale on SDM projections by conducting all analyses at four spatial resolutions. We further examined the potential effect of dispersal constraints by applying a threshold distance of maximal advancement derived from a spatially explicit, individual-based simulation model of tree line dynamics. Under current conditions, SDM s including climatic factors related to stress or growth limitation performed best. These models were then employed to project P. uncinata distribution under two emission scenarios, using data generated from several regional climate models. At the end of this century, P. uncinata is expected to migrate northward and upward, occupying habitat currently inhabited by alpine plant species. However, consideration of dispersal limitation and/or changing the spatial resolution of the analysis modified the assessment of climate change impact on mountain ecosystems, especially in the case of estimates of colonization and extinction at the regional scale. Our study highlights the need to improve the characterization of biological processes within SDMs, as well as to consider simultaneously different scales when assessing potential habitat loss under future climate conditions.
    Print ISSN: 1354-1013
    Electronic ISSN: 1365-2486
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Published by Wiley-Blackwell
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  • 9
    Publication Date: 2013-07-23
    Description: ObjectiveVenous thromboembolism (VTE) has been associated with a higher risk of developing malignancy and mortality, and patients with VTE may therefore benefit from increased surveillance. We aimed to construct a clinical predictive score that could classify patients with VTE according to their risk for developing these outcomes. Methods: Observational cohort study using an existing clinical registry in a tertiary academic teaching hospital in Buenos Aires, Argentina. 1264 adult patients greater than 17 years of age presented new VTE between June 2006 and December 2011 and were included in the registry. We excluded patients with previous or incident cancer, those who died during the first month, and those with less than one year of follow up ( 〈 5 %). 540 patients were included. Primary outcome was new cancer diagnosis during one year of follow-up, secondary composite outcome was any new cancer diagnosis or death. The score was developed using a multivariable logistic regression model to predict cancer or death. Results: During follow-up, one-quarter (26.4%) of patients developed cancer (9.2%) or died (23.7%). Patients with the primary outcome had more comorbidities, were more likely to have previous thromboembolism and less likely to have recent surgery. The final score developed for predicting cancer alone included previous episode of VTE, recent surgery and comorbidity (Charlson comorbidity score), [AUC of 0.75 (95% CI 0.66-0.84) and 0.79 (95% CI 0.63-0.95) in the derivation and validation cohorts, respectively]. The version of this score developed to predict cancer or death included age, albumin level, comorbidity, previous episode of VTE, and recent surgery [AUC = 0.72 (95% CI 0.66-0.78) and 0.71 (95% CI 0.63-0.79) in the derivation and validation cohorts, respectively]. Conclusions: A simple clinical predictive score accurately estimates patients' risk of developing cancer or death following newly diagnosed VTE. This tool could be used to help reassure low risk patients, or to identify high-risk patients that might benefit from closer surveillance and additional investigations.ClinicalTrials.gov ID: NCT01372514.KeywordsVenous thromboembolism, Thromboembolism, Cancer, Pulmonary embolism
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
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  • 10
    Publication Date: 2014-11-24
    Description: Background: The human COL11A1 gene has been shown to be up-regulated in stromal cells of colorectal tumours, but, so far, the immunodetection of procollagen 11A1, the primary protein product of COL11A1, has not been studied in detail in human colon adenocarcinomas. Some cancer-associated stromal cells seem to be derived from bone marrow mesenchymal cells; the expression of the COL11A1 gene and the parallel immunodetection of procollagen 11A1 have not been evaluated in these latter cells, either. Methods: We used quantitative RT-PCR and/or immunocytochemistry to study the expression of DES/desmin, VIM/vimentin, ACTA2/alphaSMA (alpha smooth muscle actin) and COL11A1/procollagen 11A1 in HCT 116 human colorectal adenocarcinoma cells, in immortalised human bone marrow mesenchymal cells and in human colon adenocarcinoma-derived cultured stromal cells. The immunodetection of procollagen 11A1 was performed with the new recently described DMTX1/1E8.33 mouse monoclonal antibody. Human colon adenocarcinomas and non-malignant colon tissues were evaluated by immunohistochemistry as well. Statistical associations were sought between anti-procollagen 11A1 immunoscoring and patient clinicopathological features. Results: Procollagen 11A1 was immunodetected in human bone marrow mesenchymal cells and in human colon adenocarcinoma-associated spindle-shaped stromal cells but not in colon epithelial or stromal cells of the normal colon. This immunodetection paralleled, in both kinds of cells, that of the other mesenchymal-related biomarkers studied: vimentin and alpha smooth muscle actin, but not desmin. Thus, procollagen 11A1+ adenocarcinoma-associated stromal cells are similar to "activated myofibroblasts". In the series of human colon adenocarcinomas here studied, a high procollagen 11A1 expression was associated with nodal involvement (p = 0.05), the development of distant metastases (p = 0.017), and advanced Dukes stages (p = 0.047). Conclusion: The immunodetection of procollagen 11A1 in cancer-associated stromal cells could be a useful biomarker for human colon adenocarcinoma characterisation.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
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