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  • 1
    Electronic Resource
    Electronic Resource
    Bestimmung von Diacetyl in Apfelwein (1971)
    Springer
    European food research and technology 146 (1971), S. 143-147 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Description / Table of Contents: Zusammenfassung Es wird eine rasche und exakte Bestimmungsmethode für Diacetyl in Apfelwein mittels Gaschromatographie der Head-Space-Phase beschrieben.
    Notes: Summary A rapid and exact method is described for determination of diacetyl in cider by means of head space gas chromatography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01882240
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Gaschromatographische Bestimmung der höheren Ester in Weindestillat, Weinbrand, Brennwein und Wein (1971)
    Springer
    European food research and technology 147 (1971), S. 207-213 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Description / Table of Contents: Zusammenfassung Es konnte der Nachweis erbracht werden, daß der CS2-Extrakt zur gas chromatographischen Bestimmung der höheren Ester geeigneter ist als der Ätherextrakt. Dies bezieht sich einerseits auf den Aufwand an Material, Arbeit und Zeit, andererseits auf die Genauigkeit und Reproduzierbarkeit, insbesondere hinsichtlich Äthylcapronat. Eine geeignete Methode zur Untersuchung von Weinbrand, Weindestillat, Brennwein und Wein auf ihren Gehalt an höheren Estern wird angegeben.
    Notes: Summary The CS2-extraction for the gas chromatographic analysis of the higher esters was examined and found to be superior to the ether-extraction, concerning, material, performance as well as accuracy and reproductivity, especially ethyl capronate. The exact method for the analysis of brandy, distillate and wine for their content of higher esters is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01877165
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    Paper (German National Licenses)
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  • 3
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    Transatlantic distribution of the Alaskan White River Ash (2014)
    GSA, Geological Society of America
    In:  Geology, 42 (10). pp. 875-878.
    Details
    Publication Date: 2017-05-17
    Description: Volcanic ash layers preserved within the geologic record represent precise time markers that correlate disparate depositional environments and enable the investigation of synchronous and/or asynchronous behaviors in Earth system and archaeological sciences. However, it is generally assumed that only exceptionally powerful events, such as supereruptions (≥450 km3 of ejecta as dense-rock equivalent; recurrence interval of ∼105 yr), distribute ash broadly enough to have an impact on human society, or allow us to address geologic, climatic, and cultural questions on an intercontinental scale. Here we use geochemical, age, and morphological evidence to show that the Alaskan White River Ash (eastern lobe; A.D. 833–850) correlates to the “AD860B” ash (A.D. 846–848) found in Greenland and northern Europe. These occurrences represent the distribution of an ash over 7000 km, linking marine, terrestrial, and ice-core records. Our results indicate that tephra from more moderate-size eruptions, with recurrence intervals of ∼100 yr, can have substantially greater distributions than previously thought, with direct implications for volcanic dispersal studies, correlation of widely distributed proxy records, and volcanic hazard assessment.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1130/G35945.1
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 4
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    Phage Activation by Prolyl Isomerization [Protein Structure and Folding] (2013)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2013-05-04
    Description: Infection of Escherichia coli by the filamentous phage fd starts with the binding of the N2 domain of the phage gene-3-protein to an F pilus. This interaction triggers partial unfolding of the gene-3-protein, cis → trans isomerization at Pro-213, and domain disassembly, thereby exposing its binding site for the ultimate receptor TolA. The trans-proline sets a molecular timer to maintain the binding-active state long enough for the phage to interact with TolA. We elucidated the changes in structure and local stability that lead to partial unfolding and thus to the activation of the gene-3-protein for phage infection. Protein folding and TolA binding experiments were combined with real-time NMR spectroscopy, amide hydrogen exchange measurements, and phage infectivity assays. In combination, the results provide a molecular picture of how a local unfolding reaction couples with prolyl isomerization not only to generate the activated state of a protein but also to maintain it for an extended time.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 5
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    Transatlantic distribution of the Alaskan White River Ash (2014)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2014-09-20
    Description: Volcanic ash layers preserved within the geologic record represent precise time markers that correlate disparate depositional environments and enable the investigation of synchronous and/or asynchronous behaviors in Earth system and archaeological sciences. However, it is generally assumed that only exceptionally powerful events, such as supereruptions (≥450 km 3 of ejecta as dense-rock equivalent; recurrence interval of ~10 5 yr), distribute ash broadly enough to have an impact on human society, or allow us to address geologic, climatic, and cultural questions on an intercontinental scale. Here we use geochemical, age, and morphological evidence to show that the Alaskan White River Ash (eastern lobe; A.D. 833–850) correlates to the "AD860B" ash (A.D. 846–848) found in Greenland and northern Europe. These occurrences represent the distribution of an ash over 7000 km, linking marine, terrestrial, and ice-core records. Our results indicate that tephra from more moderate-size eruptions, with recurrence intervals of ~100 yr, can have substantially greater distributions than previously thought, with direct implications for volcanic dispersal studies, correlation of widely distributed proxy records, and volcanic hazard assessment.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 6
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    Novel oral anticoagulants in a real-world cohort of patients undergoing catheter ablation of atrial fibrillation (2013)
    Oxford University Press
    In: Europace
    Details
    Publication Date: 2013-10-30
    Description: Aims Experiences with novel oral anticoagulants (NOACs) early after atrial fibrillation (AF) catheter ablation are limited and show controversial results. We aimed to assess the longer-term safety, efficacy, and acceptance of NOACs in a large real-world cohort of patients presenting for AF catheter ablation. Methods and results From July 2010 until June 2012, 259 patients undergoing AF catheter ablation were prospectively included. Novel oral anticoagulants were given for at least 3 months post-ablation. Clinical outcome (stroke, thromboembolic events, major bleeding), adverse effects, and drug adherence were assessed at discharge and follow-up. On admission patients were presented with a variety of anticoagulants including 54 patients (21%) already on NOACs prior ablation. After ablation 38% of patients received dabigatran 110 mg, 56% 150 mg, and 6% received rivaroxaban 20 mg. There were four periprocedural thromboembolic and major bleeding complications (1.5%), all in patients without NOACs prior ablation (two on warfarin and two on heparin). During long-term follow-up [311 (199; 418) days] no stroke, systemic embolism, or major haemorrhage could be observed. Uneventful electrical cardioversions and reablation procedures were performed in 27 and 12 patients on dabigatran, respectively. Novel oral anticoagulants were prematurely stopped or switched to another anticoagulant due to side effects or at the preference of the treating general practitioner in 9 and 10 patients, respectively. Conclusion In this prospective observational study, anticoagulation with NOACs following AF catheter ablation was safe and effective at long-term follow-up. Fast onset of action makes NOACs especially attractive in patients without effective anticoagulation on admission and in patients following periprocedural complications.
    Print ISSN: 1099-5129
    Electronic ISSN: 1532-2092
    Topics: Medicine
    Published by Oxford University Press
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  • 7
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    Inhibition of NK Cell Killing by a Soluble Fragment of BAG-6 [Membrane Biology] (2013)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2013-11-30
    Description: Immunosurveillance of tumor cells depends on NKp30, a major activating receptor of human natural killer (NK) cells. The human BCL2-associated athanogene 6 (BAG-6, also known as BAT3; 1126 amino acids) is a cellular ligand of NKp30. To date, little is known about the molecular details of this receptor ligand system. Within the current study, we have located the binding site of NKp30 to a sequence stretch of 250 amino acids in the C-terminal region of BAG-6 (BAG-6686–936). BAG-6686–936 forms a noncovalent dimer of 57–59 kDa, which is sufficient for high affinity interaction with NKp30 (KD 〈 100 nm). As our most important finding, BAG-6686–936 inhibits NKp30-dependent signaling, interferon-γ release, and degranulation of NK cells in the presence of malignantly transformed target cells. Based on these data, we show for the first time that BAG-6686–936 comprises a subdomain of BAG-6, which is sufficient for receptor docking and inhibition of NKp30-dependent NK cell cytotoxicity as part of a tumor immune escape mechanism. These molecular insights provide an access point to restore tumor immunosurveillance by NK cells and to increase the efficacy of cellular therapies.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 8
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    Thermoelectric effects in molecular quantum dots with contacts (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-04-25
    Description: Author(s): T. Koch, J. Loos, and H. Fehske We consider the steady-state thermoelectric transport through a vibrating molecular quantum dot that is contacted to macroscopic leads. For moderate electron-phonon interaction strength and comparable electronic and phononic timescales, we investigate the impact of the formation of a local polaron o... [Phys. Rev. B 89, 155133] Published Thu Apr 24, 2014
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 9
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    Local Effects of Pregnancy on Connexin Proteins That Mediate Ca2+-Associated Uterine Endothelial NO Synthesis [Pregnancy] (2014)
    American Heart Association (AHA)
    Details
    Publication Date: 2014-02-14
    Description: Uterine artery adaptations during gestation facilitate increases in uterine blood flow and fetal growth. Hypothesis: local expression and distribution of uterine artery connexins play roles in mediating in vivo gestational eNOS activation and NO production. We established an ovine model restricting pregnancy to a single uterine horn and measured uterine blood flow, uterine artery shear stress, connexins 37/43, and P 635 eNOS protein levels in uterine artery and systemic artery (omental and renal) endothelium and connexins in vascular smooth muscle. Uterine blood flow and shear stress were locally (unilaterally) and substantially elevated by gestation. During pregnancy, uterine artery endothelial gap junction proteins connexins 37/43 were locally regulated in the gravid horn and elevated 10.3- and 25.6-fold; uterine artery endothelial P 635 eNOS and total eNOS were elevated 3.3- and 2.9-fold; whereas uterine artery vascular smooth muscle connexins 37/43 were locally elevated 12.5- and 5.9-fold, respectively. Less pronounced changes were observed in systemic vasculature except for significant pregnancy-associated increases in omental artery vascular smooth muscle connexin 43 and omental artery endothelial P 635 eNOS and total eNOS. Gap junction blockade using connexin 43, but not connexin 37–specific Gap peptides, abrogated uterine artery endothelial ATP-induced Ca 2+ -mediated NO production. Thus, uterine artery endothelial connexin 43, but not connexin 37, regulates Ca 2+ -mediated NO production required for the vasodilation to accommodate increases in uterine blood flow and shear stress during healthy pregnancies.
    Keywords: Endothelium/vascular type/nitric oxide, Other Research
    Print ISSN: 0194-911X
    Topics: Medicine
    Published by American Heart Association (AHA)
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  • 10
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    Contrasting physiological responses of two co-occurring eucalypts to seasonal drought at restored bauxite mine sites (2011)
    Oxford University Press
    Details
    Publication Date: 2011-11-24
    Description: This study describes the physiological response of two co-occurring tree species ( Eucalyptus marginata and Corymbia ­calophylla ) to seasonal drought at low- and high-quality restored bauxite mine sites in south-western Australia. Seasonal changes in photosynthesis ( A ), stomatal conductance ( g s ), leaf water potential (), leaf osmotic potential (), leaf relative water content (RWC) and pressure–volume analysis were captured over an 18-month field study to (i) determine the nature and severity of physiological stress in relation to site quality and (ii) identify any physiological differences between the two species. Root system restriction at the low-quality site reduced maximum rates of gas exchange ( g s and A ) and increased water stress ­(midday and daily RWC) in both species during drought. Both species showed high stomatal sensitivity ­during drought; however, E. marginata demonstrated a higher dehydration tolerance where and RWC fell to –3.2 MPa and 73% compared with –2.4 MPa and 80% for C. calophylla. Corymbia calophylla showed lower g s and higher and RWC during drought, indicating higher drought tolerance. Pressure–volume curves showed that cell-wall elasticity of E. marginata leaves increased in response to drought, while C. calophylla leaves showed lower osmotic potential at zero turgor in summer than in winter, indicating osmotic adjustment. Both species are clearly able to tolerate seasonal drought at hostile sites; however, by C. ­calophylla closing stomata earlier in the drought cycle, maintaining a higher water status during drought and having the additional mechanism of osmotic adjustment, it may have a greater capacity to survive extended periods of drought.
    Print ISSN: 0829-318X
    Electronic ISSN: 1758-4469
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Oxford University Press
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