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  • Plasma renin concentration  (2)
  • Renal tubule  (2)
  • Springer  (4)
  • American Heart Association (AHA)
  • Institute of Physics Publishing (IOP)
  • Nature Publishing Group (NPG)
  • Oxford University Press
  • Periodicals Archive Online (PAO)
  • 2010-2014
  • 1975-1979  (2)
  • 1970-1974  (2)
Document type
Keywords
Publisher
  • Springer  (4)
  • American Heart Association (AHA)
  • Institute of Physics Publishing (IOP)
  • Nature Publishing Group (NPG)
  • Oxford University Press
    • +
Years
  • 2010-2014
  • 1975-1979  (2)
  • 1970-1974  (2)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Bestimmung der Plasma-Renin-Konzentration mittels Radioimmunoassays für Angiotensin I (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 702-705 
    Details
    ISSN: 1432-1440
    Keywords: Plasma renin concentration ; radioimmunoassay ; angiotensin I ; Plasma-Renin-Konzentration ; radioimmunologischer Nachweis ; Angiotensin I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein Radioimmunoassay für Angiotensin I und seine Anwendung für die Messung der Reninkonzentration im Plasma werden beschrieben. Die zur Herstellung von Angiotensinantikörpern und radioaktiv markiertem Angiotensin sowie zur Trennung von gebundenem und freiem Hormon benutzten Verfahren werden mitgeteilt. Die Empfindlichkeit der Methode erlaubt den Nachweis von zwanzig Pikogramm Angiotensin I. Zur Messung der Reninkonzentration wurde substratfreies Plasma mit Schafsubstrat im Überschuß versetzt und in Anwesenheit von Inhibitoren von „converting enzyme“ und Angiotensinasen bei 37°C inkubiert. Das gebildete Angiotensin wurde in 20 µl des proteinfreien Inkubationsgemisches bestimmt. Die initiale Geschwindigkeit der Angiotensinbildung wurde zur Berechnung der Reninkonzentration herangezogen. Als eine Einheit wurde die Reninmenge definiert, die ein Nanogramm Angiotensin I pro Stunde Inkubation bildet. Normalwerte unter kontrollierter natriumreicher und natriumarmer Diät wurden ermittelt. Die Empfindlichkeit der Methode erlaubt die Messung der Reninkonzentration im Plasma von Patienten mit primärem Aldosteronismus.
    Notes: Summary A radioimmunoassay for angiotensin I and its application to the measurement of plasma renin concentration are described. Outlined are the methods which were used to elicite antibodies against angiotensin I, to iodinate angiotensin I with iodine125, and to separate free from antibody-bound hormone. The method is sensitive enough to detect 20 picogrammes of angiotensin I. Substrate-free plasma was mixed with excess of sheep substrate. The mixture was incubated at 37°C in the presence of inhibitors of converting enzyme and angiotensinases. The generated angiotensin I was measured in 20 µl of the protein-free incubation mixture. The initial velocity of angiotensin generation was used to calculate the renin concentration. One unit was defined as the amount of renin which generates one nanogram of angiotensin per hour. Normal values of plasma renin concentration were obtained both during sodium loading and sodium depletion. The sensitivity of the method allows the measurement of plasma renin in patients with primary aldosteronism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01495529
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Die Plasma-Renin-Konzentration beim primären Hyperaldosteronismus unter Suppressions- und Stimulationsbedingungen (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 783-786 
    Details
    ISSN: 1432-1440
    Keywords: Primary aldosteronism ; Plasma renin concentration ; Primärer Hyperaldosteronismus ; Plasma-Renin-Konzentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 13 Patienten mit einem primären Hyperaldosteronismus wurde die Plasma-Renin-Konzentration unter Stimulations- und unter Suppressionsbedingungen gemessen. Eine hochempfindliche Methode zur Reninmessung, die sich eines Radioimmunoassays für Angiotensin I bediente, wurde verwandt. Bei jedem der Patienten ließ sich die Reninkonzentration im Plasma gut messen. Die Werte lagen hochsignifikant unter den Normbereichen, die unter denselben Bedingungen ermittelt worden waren. Am eindrücklichsten war der Unterschied zwischen normalen und pathologischen Werten unter Stimulationsbedingungen. Nach Kochsalzentzug stieg die Reninkonzentration zwar bei nahezu allen Patienten signifikant an, der Anstieg war jedoch subnormal, gemessen an dem gesunden Kontrollkollektiv. Renin ist auch beim primären Aldosteronismus im Plasma vorhanden und reagiert auf Stimulation qualitativ regelrecht, quantitativ jedoch subnormal.
    Notes: Summary Plasma renin concentration (PRC) was measured in thirteen patients with primary aldosteronism during high and low sodium intake. A highly sensitive method using a radioimmunoassay for angiotensin I was applied for the determinations of PRC. PRC was detectable in each patient. The values obtained were significantly lower than the normal ranges which were assessed under the same conditions. Most impressive was the difference between normal and pathological values during sodium deprivation. PRC rose in almost each patient after several days of dietary sodium restriction. The increase was subnormal, however, when compared with normal controls. Renin is present in plasma of patients with primary aldosteronism. It responds qualitatively normally, but quantitatively subnormally when stimulated by sodium deprivation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01490305
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The role of brush border enzymes in tubular reabsorption of disaccharides (1977)
    Springer
    Pflügers Archiv 371 (1977), S. 141-145 
    Details
    ISSN: 1432-2013
    Keywords: Renal tubule ; Disaccharide reabsorption ; Maltase ; Brush border enzymes ; Microperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal tubular reabsorption of maltose, sucose and lactose were studied in vivo et situ by continuous microperfusion of single proximal convolutions of rat kidney. The14C-label of maltose (2.5 mmol/l) was removed from the lumen of the proximal tubule at about the same rate as found for glucose. Maltose reabsorption was completely inhibited in presence of 30 mmol/l glucose or of 0.1 mmol/l phlorizin. Chemical analysis of the samples showed a complete conversion of maltose into glucose within a perfusion distance of 2 mm. It is concluded from these results that within the tubular lumen maltose is split very rapidly by a brush border glucosidase. The short half time of this process permits the breakdown product glucose to be almost completely reabsorbed subsequently within the proximal tubule. In contrast, sucrose and lactose were neither split nor reabsorbed by the tubule brush border.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00580782
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Amino acid reabsorption in the proximal tubule of rat kidney: Stereospecificity and passive diffusion studied by continuous microperfusion (1977)
    Springer
    Pflügers Archiv 367 (1977), S. 221-227 
    Details
    ISSN: 1432-2013
    Keywords: Amino acid transport ; Renal tubule ; Stereospecificity ; Passive diffusion ; Saturation kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal tubular reabsorption of glycine and of thel- andd-isomers of histidine, serine, phenylalamine, methionine, proline and cystine was investigated in vivo et situ by continuous microperfusion of single proximal convolutions of the rat kidney. In the case of glycine and thel-isomers, tubular reabsorption is saturable to a great extent. Thed-amino acids are reabsorbed much more slowly than the respectivel-forms. Furthermore in the case of methionine and perhaps also of proline, serine and phenylalanine, the fractional reabsorption decreases in the presence of high concentrations of thel-form. This indicates that thed-isomers also have a measurable affinity for the reabsorption mechanisms of the renal tubule. The very poor reabsorption ofd-amino acids in the presence of theirl-isomers indicates that simple passive diffusion plays only a relatively small role in tubular amino acid reabsorption. Permeability coefficients estimated from these findings are in the range from 1–5×10−7 cm2·s−1. These values are very similar to those found for other organic molecules of comparable molecular weights.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581358
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    Paper (German National Licenses)
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