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  • 2005-2009  (17)
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  • 1
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Nature 442, 671–675 (2006) We omitted the names of the following authors of this Letter: Jens Matthiessen, Kathryn Moran and Ruediger ...
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Palaeocene/Eocene thermal maximum represents a period of rapid, extreme global warming ∼55 million years ago, superimposed on an already warm world. This warming is associated with a severe shoaling of the ocean calcite compensation depth and a 〉2.5 per mil negative carbon ...
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 447 (2007), S. 577-580 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Ocean mixing affects global climate and the marine biosphere because it is linked to the ocean’s ability to store and transport heat and nutrients. Observations have constrained the magnitude of upper ocean mixing associated with certain processes, but mixing rates measured directly are ...
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Palaeocene/Eocene thermal maximum, ∼55 million years ago, was a brief period of widespread, extreme climatic warming, that was associated with massive atmospheric greenhouse gas input. Although aspects of the resulting environmental changes are well documented at low latitudes, ...
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has been suggested, on the basis of modern hydrology and fully coupled palaeoclimate simulations, that the warm greenhouse conditions that characterized the early Palaeogene period (55–45 Myr ago) probably induced an intensified hydrological cycle with precipitation exceeding ...
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  • 6
    ISSN: 1432-2072
    Keywords: Key words Neurosteroid ; Cocaine ; Ganaxolone ; Co 2-1068 ; Haloperidol ; Locomotion ; Food intake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Neuroactive steroids, including the potent anticonvulsants ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one) and Co 2-1068 (3β-(4acetylphenyl)ethynyl-3α,21-dihydroxy-5β-20-one-21-hemisuccinate), have recently been shown to protect against cocaine-induced seizures. Objectives: The purpose of the present experiments was to determine whether ganaxolone and Co 2-1068 attenuate acute behavioral effects of cocaine unrelated to seizures. Methods: In the first experiment, the locomotor effects of Co 2-1068 (10–100 mg/ kg), pentobarbital (10–100 mg/kg) and haloperidol (0.03–0.3 mg/kg), alone or in combination with cocaine (5.6–30 mg/kg), were determined in mice. In the second experiment, the effects on sucrose intake of ganaxolone (4–16 mg/kg), Co 2-1068 (8–64 mg/kg), pentobarbital (4–32 mg/kg), and haloperidol (0.04–0.4 mg/kg), alone or in combination with cocaine (4–16 mg/kg), were determined in rats. Results: Cocaine caused a dose-related increase in locomotor activity in mice, whereas Co 2-1068, pentobarbital and haloperidol caused dose-related decreases. The dopamine antagonist haloperidol, at a dose that had no effect on activity by itself, but not Co 2-1068 or pentobarbital, attenuated the cocaine-induced increase in locomotor activity. Cocaine, ganaxolone, Co 2-1068, and haloperidol produced dose-related decreases in sucrose intake in rats; the effects of pentobarbital on sucrose intake were variable. As with locomotor effects, haloperidol attenuated the cocaine-induced decrease in sucrose intake. In addition, cocaine-induced decreases in sucrose intake were attenuated by ganaxolone and Co 2-1068. Pentobarbital had no statistically significant effect on the cocaine dose-response function. Conclusions: These results suggest that the interaction of neuroactive steroids with cocaine extends to pharmacologic actions beyond anticonvulsant efficacy, but that the blockade of behavioral effects of cocaine by neuroactive steroids does not apply to all acute behaviors.
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  • 7
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    PANGAEA
    In:  Supplement to: Sluijs, Appy; Schouten, Stefan; Pagani, Mark; Woltering, Martijn; Brinkhuis, Henk; Sinninghe Damsté, Jaap S; Dickens, Gerald Roy; Huber, Matthew; Reichart, Gert-Jan; Stein, Ruediger; Matthiessen, Jens; Lourens, Lucas Joost; Pedentchouk, Nikolai; Backman, Jan; Moran, Kathryn; Expedition 302 Scientists (2006): Subtropical Arctic Ocean temperatures during the Palaeocene/Eocene thermal maximum. Nature, 441, 610-613, https://doi.org/10.1038/nature04668
    Publication Date: 2023-07-10
    Description: The Palaeocene/Eocene thermal maximum, 55 million years ago, was a brief period of widespread, extreme climatic warming (Zachos et al., 2003; Kennett and Stott, 1991, doi:10.1038/353225a0; Tripati and Elderfield, 2005, doi:10.1126/science.1109202), that was associated with massive atmospheric greenhouse gas input (Dickens et al., 1995, doi:10.1029/95PA02087). Although aspects of the resulting environmental changes are well documented at low latitudes, no data were available to quantify simultaneous changes in the Arctic region. Here we identify the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence obtained during the Arctic Coring Expedition (Backman et al., 2006, doi:10.2204/iodp.proc.302.2006). We show that sea surface temperatures near the North Pole increased from 18 °C to over 23 °C during this event. Such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming. At the same time, sea level rose while anoxic and euxinic conditions developed in the ocean's bottom waters and photic zone, respectively. Increasing temperature and sea level match expectations based on palaeoclimate model simulations (Shellito et al., 2003, doi:10.1016/S0031-0182(02)00718-6), but the absolute polar temperatures that we derive before, during and after the event are more than 10 °C warmer than those model-predicted. This suggests that higher-than-modern greenhouse gas concentrations must have operated in conjunction with other feedback mechanisms -perhaps polar stratospheric clouds (Sloan and Pollard, 1998, doi:10.1029/98GL02492) or hurricane-induced ocean mixing (Emanuel et al., 2004, doi:10.1175/1520-0469(2004)061〈0843:ECOTCI〉2.0.CO;2)- to amplify early Palaeogene polar temperatures.
    Keywords: 302-M0004A; ACEX-M4A; Angiosperms; Apectodinium spp.; Arctic Coring Expedition, ACEX; Arctic Ocean; Areoligera complex; Caligodinium aceras; CCGS Captain Molly Kool (Vidar Viking); Cerodinium complex; Cordosphaeridium complex; DEPTH, sediment/rock; Dinoflagellate cyst; Dinoflagellate cyst, low salinity tolerant; Dinoflagellate cyst indeterminata; DSDP/ODP/IODP sample designation; Exp302; Foraminifera, linings per unit mass; Integrated Ocean Drilling Program / International Ocean Discovery Program; IODP; Membranosphaera complex; Palynomorpha, marine; Palynomorpha, terrestrial; Pollen, angiosperms; Pollen, gymnosperms; Polysphaeridium complex; Sample code/label; Senegalinium spp.; Spiniferites complex; Spores
    Type: Dataset
    Format: text/tab-separated-values, 1185 data points
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  • 8
    Publication Date: 2024-01-09
    Keywords: 151-913B; AGE; Albiespollenites spp.; Alnipollenites verus; Appendicidites spp.; Aquilapollenites spp.; Azolla spp.; Basopollis spp.; Caryapollenites simplex; Cedripites; Chenopodipollis spp.; Cicatricosisporites spp.; Comment; Compositoipollenites rhizophorus; Cupuliferoidaepollenites liblarensis; Cyclongranulates; Deltoidospora spp.; DEPTH, sediment/rock; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Ericipites spp.; Foveosporites spp.; Gleicheniidites spp.; Hydrosporis azollensis; Ilexpollenites spp.; Inaperturopollenites hiatus; Joides Resolution; Laevigatosporites spp.; Leg151; Leotrilites spp.; Lonicera; Lycopodiumsporites spp.; Microfoveolatosporites spp.; Milfordia foveosporites; Momipites coryloides; Monocolpollenites spp.; North Greenland Sea; Nyssapollenites spp.; Ocean Drilling Program; ODP; Osmundacidites spp.; Piceapollis spp.; Pinus spp.; Pistillipollenites mcgregorii; Platycaryapollenites platycaryoides; Podocarpidites spp.; Pollen, total; Pollen indeterminata; Polyatriopollenites spp.; Polypodiaceiosporites spp.; Porocolpopollenites vestibulum; Radialisporis spp.; Retitricolpites spp.; Salixpollenites spp.; Sample code/label; Sciadopityspollenites spp.; Sequoiapollenites polyformosus; Stereisporites spp.; Striamonoletes spp.; Subtriporopollenites spp.; Tetracolporopollenites spp.; Tiliaepollenites microreticulatus; Toriosporites spp.; Triatriopollenites subtriangulus; Tricolpites spp.; Tricolporopollenites spp.; Trilites spp.; Triplanosporites spp.; Triporopollenites plektosus; Triporopollenites robustus; Triporopollenites spp.; Trudopollis spp.; Tsuga spp.; Ulmus spp.; Verrucosisporites spp.
    Type: Dataset
    Format: text/tab-separated-values, 6510 data points
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  • 9
    Publication Date: 2024-01-09
    Keywords: 104-643A; AGE; Albiespollenites spp.; Alnipollenites verus; Appendicidites spp.; Aquilapollenites spp.; Azolla spp.; Basopollis spp.; Caryapollenites simplex; Cedripites; Chenopodipollis spp.; Cicatricosisporites spp.; Compositoipollenites rhizophorus; Cupuliferoidaepollenites liblarensis; Cyclongranulates; Deltoidospora spp.; DEPTH, sediment/rock; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Ericipites spp.; Foveosporites spp.; Gleicheniidites spp.; Hydrosporis azollensis; Ilexpollenites spp.; Inaperturopollenites hiatus; Joides Resolution; Laevigatosporites spp.; Leg104; Leotrilites spp.; Lycopodiumsporites spp.; Microfoveolatosporites spp.; Milfordia foveosporites; Momipites coryloides; Monocolpollenites spp.; Norwegian Sea; Nyssapollenites spp.; Ocean Drilling Program; ODP; Osmundacidites spp.; Pandaniidites spp.; Piceapollis spp.; Pinus spp.; Pistillipollenites mcgregorii; Platycaryapollenites platycaryoides; Podocarpidites spp.; Pollen indeterminata; Polyatriopollenites spp.; Polypodiaceiosporites spp.; Porocolpopollenites vestibulum; Radialisporis spp.; Retitricolpites spp.; Salixpollenites spp.; Sample code/label; Sciadopityspollenites spp.; Sequoiapollenites polyformosus; Stereisporites spp.; Striamonoletes spp.; Subtriporopollenites spp.; Tetracolporopollenites spp.; Tiliaepollenites microreticulatus; Toriosporites spp.; Triatriopollenites subtriangulus; Tricolpites spp.; Tricolporopollenites spp.; Trilites spp.; Triplanosporites spp.; Triporopollenites plektosus; Triporopollenites robustus; Triporopollenites spp.; Trudopollis spp.; Tsuga spp.; Ulmus spp.; Verrucosisporites spp.
    Type: Dataset
    Format: text/tab-separated-values, 768 data points
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  • 10
    Publication Date: 2024-01-09
    Keywords: 162-985A; AGE; Albiespollenites spp.; Alnipollenites verus; Appendicidites spp.; Aquilapollenites spp.; Azolla spp.; Basopollis spp.; Caryapollenites simplex; Cedripites; Chenopodipollis spp.; Cicatricosisporites spp.; Compositoipollenites rhizophorus; Cupuliferoidaepollenites liblarensis; Cyclongranulates; Deltoidospora spp.; DEPTH, sediment/rock; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Ericipites spp.; Foveosporites spp.; Gleicheniidites spp.; Hydrosporis azollensis; Ilexpollenites spp.; Inaperturopollenites hiatus; Joides Resolution; Laevigatosporites spp.; Leg162; Leotrilites spp.; Lycopodiumsporites spp.; Microfoveolatosporites spp.; Milfordia foveosporites; Momipites coryloides; Monocolpollenites spp.; Norwegian Sea; Nyssapollenites spp.; Ocean Drilling Program; ODP; Osmundacidites spp.; Pandaniidites spp.; Piceapollis spp.; Pinus spp.; Pistillipollenites mcgregorii; Platycaryapollenites platycaryoides; Podocarpidites spp.; Pollen, total; Pollen indeterminata; Polyatriopollenites spp.; Polypodiaceiosporites spp.; Porocolpopollenites vestibulum; Radialisporis spp.; Retitricolpites spp.; Salixpollenites spp.; Sample code/label; Sciadopityspollenites spp.; Sequoiapollenites polyformosus; Stereisporites spp.; Striamonoletes spp.; Subtriporopollenites spp.; Tetracolporopollenites spp.; Tiliaepollenites microreticulatus; Toriosporites spp.; Triatriopollenites subtriangulus; Tricolpites spp.; Tricolporopollenites spp.; Trilites spp.; Triplanosporites spp.; Triporopollenites plektosus; Triporopollenites robustus; Triporopollenites spp.; Trudopollis spp.; Tsuga spp.; Ulmus spp.; Verrucosisporites spp.
    Type: Dataset
    Format: text/tab-separated-values, 715 data points
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