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  • 1
    Online-Ressource
    Online-Ressource
    Newark :John Wiley & Sons, Incorporated,
    Schlagwort(e): Hazardous substances -- Risk assessment. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (201 pages)
    Ausgabe: 1st ed.
    ISBN: 9780470937969
    Sprache: Englisch
    Anmerkung: Intro -- Concentration Fluctuations and Averaging Time in Vapor Clouds -- Contents -- PREFACE -- ACKNOWLEDGMENTS -- 1. Background and Objectives -- 2. Sampling and Averaging Time Definitions -- Calculating Mass-Weighted Sampling Time -- Effective Sampling Time ts,a for Block Time Averages -- 3. Effect of Averaging Time on Mean Calculations -- Ensemble Averaging and Zero Sample Time Meandering -- Field Data for Sampling and Averaging Time Effects -- Plume Spread Sampling Time Effects Deduced from Velocity Fluctuation Statistics -- Measurement of Crosswind-Velocity Sampling Time Exponent pv -- Averaging Time Effects on Plume Spread σy -- Random Force Model for Sampling Time Effects on Crosswind Spread -- Comparing the Random Force Model to CONDORS Data -- Comparing the Random Force Model with σy ~ ts0.2 -- 4. Concentration Fluctuation Modeling -- Overview -- Types of Concentration Fluctuation Models -- Conditional Statistics for Fluctuation Calculations -- Wind Tunnel Simulation versus Field Testing for Model Validation -- 5. Probability Distributions -- Exponential Probability Distribution -- Clipped-Normal Probability Distribution -- Log-Normal Probability Distribution -- Gamma Probability Distribution -- Recommended Probability Distribution and Conditional Intensity Functions -- 6. Release Height and Source Size Effects on Fluctuation Intensity -- Internal Fluctuations in Jets and Plumes with No Meandering -- Fluctuation Intensity in Meandering Plumes from Ground Level Releases -- Meandering Plume Models for Source Size Effects on Elevated Releases -- Comparison with Chatwin and Sullivan's Similarity Model -- Release Momentum Effects on Source Size -- Fluctuations Near the Ground: Dissipation by Wind Shear -- Terrain Roughness, Atmospheric Stability, and Compatibility with Existing Hazard Assessment Models. , 7. Source Density Effects on Fluctuations -- Dense Plumes -- Buoyant Plumes -- 8. Buildings and Obstacles -- Modeling Concentration Fluctuations in Building Wakes -- 9. Threshold Crossing and Peak Levels -- Time Sequence versus Ensemble Repeat Averages -- 10. Framework for an Operational Model -- Adjusting Mean Concentration for Averaging Time -- Concentration Fluctuation Statistics -- Concentration Fluctuation Intensity -- Fraction of Time Threshold Concentration Is Exceeded -- Once-per-Event Peak Concentration -- Summary -- Appendix A Averaging and Sampling Time Effects on Plume Spread Velocity and Concentration Fluctuations -- Inertialess Fluctuation Spectrum -- Concentration Fluctuations -- Effect of Averaging Time on Concentration Variance -- Power Law Exponent qc for Averaging Time -- Effect of Sampling Time on Concentration Variance -- Power Law Exponent pc for Increased Sampling Time -- Velocity Fluctuations -- Sampling Time Effects on Crosswind Velocity Variance -- Sampling Time Effects for the Transverse Isotropic Spectrum -- Averaging Time Effects for Finite Sampling Time -- Gifford's Random Force Model for σy -- Wilson's Power Law Approximation to Gifford's Random Force Model -- Relative "Instantaneous" Spread vs. Fixed Axis Zero Sample Time Spread -- General Power-Law Plume Spread Equation -- Appendix B Peak Values and Threshold Crossing Probability -- Hazard Probability of Exceeding a Threshold for a Random Starting Time in an Established Steady Release -- Probability of G*(t) of First Crossing Threshold c* -- Hazard Rate h* for a Steady Release Rate -- Quasi-Steady Approximation for Time-Varying Release -- Peak-to-Mean Concentrations -- Rice's Theory for Threshold Upcrossing Rate N+ -- Threshold Crossing N+ Using In-Plume Statistics -- Exponential pdf for Derivatives -- Markov Spectrum for Derivatives. , Von Karman Spectrum for Derivatives -- Cutoff Frequency for Concentration Derivative Spectrum -- Estimating In-Plume Derivative for Threshold Crossing Rate -- Dependence of Peak Concentration on Averaging and Sampling Times -- Summary of Working Equations for Threshold Crossing -- Appendix C Eulerian and Lagrangian Turbulence Scales -- Crosswind Velocity Time Scale -- Vertical Velocity Time Scale -- Recommendation -- REFERENCES -- NOMENCLATURE -- INDEX.
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  • 2
    Online-Ressource
    Online-Ressource
    Newark :John Wiley & Sons, Incorporated,
    Schlagwort(e): Biology. ; Genetics. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (290 pages)
    Ausgabe: 1st ed.
    ISBN: 9781444313222
    Serie: Eleventh Hour - Boston Series
    DDC: 570
    Sprache: Englisch
    Anmerkung: Introduction to Biology -- CONTENTS -- 11TH HOUR GUIDE TO SUCCESS -- PREFACE -- Unit I: FROM ATOMS TO LIVING CELLS -- 1: Introduction to Biology -- TOPIC 1: A BRIEF HISTORY OF LIFE AND THE UNIVERSE -- TOPIC 2: MAJOR GENERALIZATIONS ABOUT LIFE -- TOPIC 3: SCIENTIFIC METHOD -- 2: Atoms, Bonds, Water, and Carbon -- TOPIC 1: ATOMS -- TOPIC 2: CHEMICAL BONDS -- TOPIC 3: WATER: pH AND HYDROGEN BONDS -- TOPIC 4: CARBON: TETRAHEDRAL BONDS AND ISOMERS -- 3: Molecules and Macromolecules of Life -- TOPIC 1: FUNCTIONAL GROUPS -- TOPIC 2: CARBOHYDRATES -- TOPIC 3: LIPIDS -- TOPIC 4: AMINO ACIDS AND PROTEINS -- TOPIC 5: NUCLEOTIDES AND NUCLEIC ACIDS -- 4: Membrane Structure and Function -- TOPIC 1: MEMBRANE STRUCTURE -- TOPIC 2: PASSIVE TRANSPORT ACROSS MEMBRANES -- TOPIC 3: ACTIVE TRANSPORT ACROSS MEMBRANES -- 5: Cellular Organization -- TOPIC 1: NUCLEUS, ENDOPLASMIC RETICULUM, AND GOLGI APPARATUS -- TOPIC 2: CELLULAR ORGANELLES -- TOPIC 3: CYTOSKELETON AND CELL JUNCTIONS -- 6: Energy and Enzymes -- TOPIC 1: THERMODYNAMICS, HEAT, AND ENTROPY -- TOPIC 2: FREE ENERGY AND COUPLING -- TOPIC 3: HOW ENZYMES WORK -- TOPIC 4: ENZYME REGULATION AND INHIBITION -- 7: Energy Metabolism and Cell Respiration -- TOPIC 1: OXIDATION, REDUCTION, AND NADH -- TOPIC 2: GLYCOLYSIS -- TOPIC 3: KREBS (CITRIC ACID) CYCLE -- TOPIC 4: ELECTRON TRANSPORT CHAIN AND OXIDATIVE PHOSPHORYLATION -- TOPIC 5: FERMENTATION -- 8: Photosynthesis: Harnessing Energy for Life -- TOPIC 1: CHLOROPLASTS AND CHLOROPHYLL -- TOPIC 2: LIGHT REACTIONS -- TOPIC 3: CALVIN (CALVIN-BENSON) CYCLE -- Unit I Exam -- Unit II: GENES, INFORMATION, AND HEREDITY -- 9: DNA Structure, Function, and Replication -- TOPIC 1: EVIDENCE THAT DNA IS THE GENETIC MATERIAL -- TOPIC 2: DNA STRUCTURE -- TOPIC 3: DNA REPLICATION -- 10: RNA and Protein: Transcription, Translation, and the Genetic Code -- TOPIC 1: TRANSCRIPTION. , TOPIC 2: KINDS OF RNA AND RIBOSOME CONSTRUCTION -- TOPIC 3: THE GENETIC CODE -- TOPIC 4: TRANSLATION -- 11: Cell Cycle, Mitosis, and Meiosis -- TOPIC 1: THE CELL CYCLE AND MITOSIS -- TOPIC 2: MEIOSIS -- TOPIC 3: SEXUAL REPRODUCTION AND GENETIC VARIATION -- 12: Mendelian Genetics -- TOPIC 1: MENDEL'S RULES AND GENETIC VARIATION -- TOPIC 2: GENETIC CROSSES -- TOPIC 3: COMPLEXITIES -- TOPIC 4: PEDIGREE ANALYSIS -- 13: Recombination, Linkage, and Mapping -- TOPIC 1: SEX-LINKED INHERITANCE -- TOPIC 2: LINKAGE AND RECOMBINATION -- TOPIC 3: GENETIC MAPPING -- 14: Genetics of Bacteria and Viruses -- TOPIC 1: VIRUSES AND THEIR LIFE CYCLES -- TOPIC 2: BACTERIA: GENETIC RECOMBINATION AND PLASMIDS -- TOPIC 3: OPERONS AND THE REGULATION OF PROKARYOTIC GENE EXPRESSION -- 15: Gene Expression, Gene Technology, and Human Genetics -- TOPIC 1: REGULATION OF GENE EXPRESSION IN EUKARYOTIC CELLS -- TOPIC 2: HUMAN GENETIC DISORDERS -- TOPIC 3: GENE TECHNOLOGY: CLONES, PLASMIDS, PCR, AND RFLPs -- Unit II Exam -- Unit III: EVOLUTION -- 16: Evolution and Natural Selection -- TOPIC 1: EVOLUTION: HISTORY AND EVIDENCE -- TOPIC 2: NATURAL SELECTION -- 17: Microevolution and Population Genetics -- TOPIC 1: MICROEVOLUTION AND HARDY-WEINBERG EQUILIBRIUM -- TOPIC 2: GENETIC VARIATION IN POPULATIONS -- Unit IV: ANIMAL PHYSIOLOGY -- 18: General Principles of Physiology -- TOPIC 1: TISSUES, ORGAN SYSTEMS, AND SURFACE AREA -- TOPIC 2: HOMEOSTASIS AND TEMPERATURE REGULATION -- 19: Cardiovascular System -- TOPIC 1: HEART -- TOPIC 2: ARTERIES, CAPILLARIES, VEINS, AND BLOOD -- 20: Endocrine System and Hormones -- TOPIC 1: MECHANISMS OF HORMONE ACTION -- TOPIC 2: ENDOCRINE GLANDS AND THEIR CONTROL IN VERTEBRATES -- TOPIC 3: EXAMPLES OF HORMONAL REGULATION -- 21: Neurons: Electrical and Synaptic Events -- TOPIC 1: NEURONS, CIRCUITS, AND RESTING POTENTIALS -- TOPIC 2: THE ACTION POTENTIAL. , TOPIC 3: RECEPTOR POTENTIALS AND SYNAPTIC POTENTIALS -- TOPIC 4: SYNAPTIC TRANSMISSION -- 22: Immune System and Body Defenses -- TOPIC 1: THE BODY'S DEFENSE MECHANISMS -- TOPIC 2: B CELLS, T CELLS, AND THE IMMUNE RESPONSE -- Units III and IV Exam -- Unit V: ECOLOGY -- 23: Ecology -- TOPIC 1: FOOD WEBS AND PRODUCTIVITY -- TOPIC 2: CHEMICAL CYCLING IN ECOSYSTEMS -- TOPIC 3: LIFE HISTORY CHARACTERISTICS AND POPULATION DYNAMICS -- Final Exam -- INDEX.
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  • 3
    Publikationsdatum: 2021-11-06
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Inbook , peerRev
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  • 4
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Biochemistry 34 (1995), S. 3386-3395 
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
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  • 5
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: The present study describes the relationships of extracellular striatal dopamine, cortical oxygen pressure, and striatal hydroxyl radicals in brain of newborn piglets during hypoxia and posthypoxic reoxygenation. Hypoxia was induced by reducing the fraction of inspired oxygen (FiO2) from 22% (control) to 7% for 1 h. The FiO2 was then returned to the control value and measurements were continued for 2 h. Cerebral oxygen pressure was measured by the oxygen dependent quenching of phosphorescence and extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and hydroxy radicals in the striatum were determined by in vivo microdialysis. Hypoxia decreased the cortical oxygen pressure from 47 ± 2 to 9 ± 1.3 torr (p 〈 0.001); the levels of extracellular dopamine in the striatum increased to 16,000 ± 3,270% of control (p 〈 0.01), whereas the levels of DOPAC and HVA decreased to 25.3 ± 6% (p 〈 0.001) and 36 ± 5% (p 〈 0.01) of control, respectively. Compared with control, the hydroxyl radical levels at each time point were not significantly increased during hypoxia, although the sum of the measured values was significantly increased (p 〈 0.05). During the first 5 min after FiO2 was returned to 22%, the cortical oxygen pressure increased to control values and stayed at this level for the remainder of the measurement period. The extracellular level of dopamine declined to values not statistically different from control during 40 min of reoxygenation. During the first 10 min of reoxygenation, DOPAC and HVA further decreased and then began to slowly increase. By 70 min of reoxygenation, the values were not significantly different from control. Hydroxyl radicals were above control during the entire period of reoxygenation, with maximal values observed after 100 min of reoxygenation. This increase was largely abolished by injecting the animals with α-methyl-p-tyrosine 5 h before hypoxia, a procedure that depleted the brain of dopamine. Our results suggest that oxidation of striatal dopamine during posthypoxic reoxygenation is at least partly responsible for the observed increase in striatal level of hydroxyl radicals that may exacerbate posthypoxic cerebral injury.
    Materialart: Digitale Medien
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  • 6
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: The present study tests the hypothesis that ventilation with 100% O2 during recovery from asphyxia leads to greater disturbance in brain function, as measured by dopamine metabolism, than does ventilation with 21% oxygen. This hypothesis was tested using mechanically ventilated, anesthetized newborn piglets as an animal model. Cortical oxygen pressure was measured by the oxygen-dependent quenching of phosphorescence, striatal blood flow by laser Doppler, and the extracellular levels of dopamine and its metabolites by in vivo microdialysis. After establishment of a baseline, both the fraction of inspired oxygen (FiO2) and the ventilator rate were reduced in a stepwise fashion every 20 min over a 1-h period. For the subsequent 2-h recovery, the animals were randomized to breathing 21 or 100% oxygen. It was observed that during asphyxia cortical oxygen pressure decreased from 36 to 7 torr, extracellular dopamine increased 8,300%, and dihydroxyphenylacetic acid and homovanillic acid decreased by 65 and 60%, respectively, compared with controls. During reoxygenation after asphyxia, cortical oxygen pressure was significantly higher in the piglets ventilated with 100% oxygen than in those ventilated with 21% oxygen (19 vs. 11 torr). During the first hour of reoxygenation, extracellular dopamine levels decreased to ∼200% of control in the 21% oxygen group, whereas these levels were still much higher in the 100% oxygen group (∼500% of control). After ∼2 h of reoxygenation, there was a secondary increase in extracellular dopamine to ∼750 and ∼3,000% of baseline for the animals ventilated with 21 and 100%, respectively. It is concluded that although 100% FiO2 after asphyxia increases cortical oxygenation compared with 21% FiO2, it also results in poorer recovery in dopamine metabolism and higher secondary release of striatal dopamine. The resulting increased extracellular levels of dopamine may exacerbate posthypoxic cerebral injury.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 102 (1995), S. 0 
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 7 (1995), S. 3083-3090 
    ISSN: 1089-7666
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: We review Sawford's [Phys. Fluids A 3, 1577 (1991)] second-order Lagrangian stochastic model for particle trajectories in low Reynolds number turbulence, showing that it satisfies a well-mixed constraint for the (hypothetical) case of stationary, homogeneous, isotropic turbulence in which the joint probability density function for the fixed-point velocity and acceleration is Gaussian. We then extend the model to decaying homogeneous turbulence and, by optimizing model agreement with the measured spread of tracers in grid turbulence, estimate that Kolmogorov's universal constant (C0) for the Lagrangian velocity structure function has the value of 3.0±0.5. © 1995 American Institute of Physics.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Langmuir 11 (1995), S. 265-272 
    ISSN: 1520-5827
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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