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  • Ecology  (1)
  • Fibrinolysis  (1)
  • 2020-2022  (1)
  • 2000-2004  (1)
  • 1945-1949
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  • 2020-2022  (1)
  • 2000-2004  (1)
  • 1945-1949
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Medizinische Klinik 95 (2000), S. 683-688 
    ISSN: 1615-6722
    Keywords: Schlüsselwörter Renin-Angiotensin-Aldosteron-System ; Fibrinolyse ; PAI-1 ; t-PA ; Key words Renin-angiotensin-aldosterone system ; Fibrinolysis ; PAI-1 ; t-PA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Experimental, genetic and clinical evidence suggests that the renin-angiotensin-aldosterone system (RAAS) may participate in the pathogenesis of thromboembolic cardiovascular disorders such as coronary heart disease. This interrelationship may involve mechanisms other than changes in arterial blood pressure. In addition to various possible interactions, accumulating evidence suggests that the RAAS is involved in the regulation of fibrinolytic system. Several recent studies have shown that stimulation of the RAAS may be associated with an activation of plasminogen activator inhibitor 1 (PAI-1). Since profibrinolytic factors (especially tissue plasminogen activator [t-PA]) remain unchanged, increased activity of the RAAS may thus alter the fibrinolytic balance towards a decreased fibrinolytic activity. These findings may be of special importance for a variety of clinical problems such as the long-term effect of a low NaCl-intake on cardiovascular morbidity and mortality and the possible value of drugs indirectly or directly interfering with the RAAS such as diuretics, ACE-inhibitors and angiotensin II Type 1 (AT1) receptor antagonists.
    Notes: Zusammenfassung Experimentelle, genetische und klinische Studien legen einen Zusammenhang zwischen dem Renin-Angiotensin-Aldosteron-System (RAAS) und der Entwicklung thromboembolischer kardiovaskulärer Erkrankungen, wie zum Beispiel der koronaren Herzkrankheit, nahe. Dabei ist die Verknüpfung, zumindest nicht ausschließlich, über Änderungen des arteriellen Blutdruckes vermittelt. Neben vielen anderen möglichen Mechanismen weist eine Reihe neuerer Untersuchungen darauf hin, dass das RAAS an der Regulation der Fibrinolyse beteiligt sein könnte. So zeigen verschiedene Studien, dass eine Aktivierung des RAAS mit einer gesteigerten Freisetzung des Plasminogenaktivator-Inhibitor-1 (PAI-1) einhergeht. Bei unveränderter Aktivität profibrinolytischer Faktoren (insbesondere des Gewebe-Plasminogenaktivators [t-PA]) wäre ein aktiviertes RAAS dementsprechend mit einer Änderung des fibrinolytischen Gleichgewichts und Hemmung der Fibrinolyse assoziiert. Diese Befunde sind von potentieller Bedeutung für eine Reihe von klinischen Fragestellungen, so zum Beispiel der Wertigkeit einer Kochsalzrestriktion für kardiovaskuläre Morbidität und Letalität oder aber der Bedeutung von Pharmaka, die indirekt oder direkt in das RAAS eingreifen, wie zum Beispiel Diuretika, ACE-Hemmstoffe und Angiotensin-II-Typ-1-(AT1–)Rezeptorantagonisten.
    Type of Medium: Electronic Resource
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  • 2
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    Unknown
    In:  http://aquaticcommons.org/id/eprint/8700 | 403 | 2012-06-07 14:51:15 | 8700 | United States National Marine Fisheries Service
    Publication Date: 2021-06-25
    Description: The broad distribution of Pacific sardine (Sardinops sagax)along the Pacif ic coast of North America makes it difficult for fisheries managers to identify regionalstocks of this dominant small pelagic species. An investigation of morphometric characteristics of otoliths ofPacific sardine across most of their range revealed regional differences in populations. In a survey of over 2000 otoliths, all ages (with an emphasis on age-1 recruits) were compared. Principal components analysis, multivariate analysis of variance, and a novel method derived from regression and residuals calculations, termedperimeter-weight profiles (PWPs), revealed otolith similarities and differences. The results of the differentapproaches to statistical comparisons did not always agree. Sardine otoliths from Mexican waters were generallylighter and more lobate than those from U.S. and Canadian populations. Age-1 otoliths from northern California in 2006–07 tended to be heavier and smoother than those from other areas, including year-class cohorts from southern California. Comparisons of age-groups and year-classes of northern California otoliths with the use of the PWP models indicated signif icant trends in year-to-year patterns. In conjunction with other established indices of populationstructure, otolith PWPs are a useful tool for identifying local and regional stocks of Pacific sardine and may helpdistinguish populations of other fish species as well.
    Keywords: Biology ; Ecology ; Fisheries
    Repository Name: AquaDocs
    Type: article , TRUE
    Format: application/pdf
    Format: application/pdf
    Format: 402-415
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